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Comfort Inn & Suites Sikeston I-55

2.5 star property
Enjoy the indoor pool at this Sikeston hotel

Choose dates to view prices

Photo gallery for Comfort Inn & Suites Sikeston I-55

Exterior
Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks
Meeting facility
Lobby
Breakfast area

Reviews

8.4 out of 10
Very good

Popular amenities

  • Gym
  • Laundry
  • Pet friendly
  • Parking included
  • Free WiFi

Explore the area

View in a map
109 Matthews Ln, Sikeston, MO, 63801
  • Place, City of Miner Convention Center
    ‪5 min walk‬
  • Place, Isle Casino Cape Girardeau
    ‪33 min drive‬
  • Place, Southeast Missouri State University
    ‪33 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪24 min drive‬

Room options

View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(11 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Suite, 1 King Bed with Sofa bed, Non Smoking

  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 1 King Bed, Accessible, Non Smoking

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(14 reviews)
  • Sleeps 2
  • 1 King Bed

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Exterior

Hampton Inn Sikeston

Sikeston
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
4.5 out of 5, Wonderful, 436 reviews
$95 nightly
The price is $108
Dec 7 - Dec 8
Total with taxes and fees
Hampton Inn Sikeston

About the neighborhood

Sikeston

In Sikeston .A stay at this hotel places you within half a mile (1 km) of City of Miner Convention Center and 6 miles (10 km) of Sikeston Depot Museum. Central Park is within 6 miles (10 km) and Front Street Studio & Art Gallery is within 9 miles (15 km).

What's nearby

  • City of Miner Convention Center - 5 min walk - 0.3 miles
  • Saint Francis Medical Center - 28 min drive - 36.0 miles
  • Isle Casino Cape Girardeau - 33 min drive - 38.0 miles
  • Southeast Missouri State University - 33 min drive - 38.5 miles
  • Show Me Center - 34 min drive - 39.1 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

Restaurants

  • ‪Lambert's Cafe - ‬17 min walk
  • ‪Buffalo Wild Wings - ‬5 min drive
  • ‪Pizza Inn - ‬2 min drive
  • ‪Burger King - ‬4 min drive
  • ‪McDonald's - ‬2 min walk

About this property

Comfort Inn & Suites Sikeston I-55

Enjoy the indoor pool at this Sikeston hotel
Comfort Inn & Suites Sikeston I-55 offers its guests an indoor pool and a fitness center. WiFi is free in public spaces. There's an onsite business center. The business-friendly Comfort Inn & Suites Sikeston I-55 also features laundry facilities, a front-desk safe, and an elevator. Self parking is free.
  • 64 guestrooms or units
  • 3 levels
  • Business facilities
  • Self-service laundry
  • Front desk (24 hours)
  • Front-desk safe
  • Elevator
Comfort Inn & Suites Sikeston I-55 offers 64 air-conditioned accommodations with coffee/tea makers. Guests can surf the web using the complimentary wireless Internet access.

Bathrooms include bathtubs or showers. Business-friendly amenities include desks and phones.

Similar properties

Property amenity
Drury Inn & Suites Sikeston, MO
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
4.7 out of 5, Exceptional, 1,008 reviews
$90 nightly
The price is $103
Dec 4 - Dec 5
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Property amenities

Family friendly

  • Indoor pool
  • Laundry facilities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Things to do

  • Gym
  • Indoor pool

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible registration desk

Room amenities

Entertainment

  • Cable/satellite channels

Bedroom

  • Bedsheets provided

Bathroom

  • Bathtub or shower
  • Private bathroom
  • Towels provided

Food and drink

  • Coffee/tea maker

More

  • Air conditioning
  • Desk
  • Phone

Policies

Check-in

Check-in start time: 2:00 PM; Check-in end time: anytime
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 20 per pet, per night
  • Only dogs and cats are allowed
  • Maximum 2 (weight limit: 20 lbs per pet)
  • Certain rooms only
  • You can request a pet-friendly room by reaching out to the property at the number on the booking confirmation
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Pet fee: USD 20 per pet, per night
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, American Express, Discover, JCB International, and Carte Blanche. Cash is not accepted. This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice).

We should mention

  • Pets are welcome in specific rooms only, which can be requested by contacting the property directly at the number on your booking confirmation (please see the Fees section for related charges).

Property is also known as

Comfort Inn Sikeston Hotel
Comfort Inn Sikeston

Frequently asked questions

How close is Comfort Inn & Suites Sikeston I-55 to the airport?

Comfort Inn & Suites Sikeston I-55 is 28.1 mi (29-min drive) away from the Cairo, IL (CIR-Cairo Regional) airport, the closest popular airport to the property.

How much does it cost to stay at Comfort Inn & Suites Sikeston I-55?

As of Nov 29, 2025, prices found for a 1-night stay for 2 adults at Comfort Inn & Suites Sikeston I-55 on Dec 8, 2025 start from $84.15, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Comfort Inn & Suites Sikeston I-55 have an airport shuttle?

Airport shuttle services are not available at Comfort Inn & Suites Sikeston I-55.

Does Comfort Inn & Suites Sikeston I-55 offer free breakfast?

Comfort Inn & Suites Sikeston I-55 does not offer free breakfast.

Is there a casino at Comfort Inn & Suites Sikeston I-55?

No, there is no casino at this hotel.

What time is check-in at Comfort Inn & Suites Sikeston I-55?

Check-in start time: 2:00 PM; Check-in end time: anytime.

Is there free parking at Comfort Inn & Suites Sikeston I-55?

This hotel offers free self parking.

Does Comfort Inn & Suites Sikeston I-55 have a pool?

Comfort Inn & Suites Sikeston I-55 features an indoor pool.

Does Comfort Inn & Suites Sikeston I-55 have a spa?

There are no spa services available at this hotel.

How close is Comfort Inn & Suites Sikeston I-55 to downtown Sikeston?

Comfort Inn & Suites Sikeston I-55 is 0.1 mi away from Miner.