Explore 697 Luxury Hotels in Ohio River Valley

Name: The Cincinnatian Hotel Curio Collection by Hilton
Price range: $175 total
Rating: 7.6

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Best Luxury Hotels in Ohio River Valley

Hotel Covington Cincinnati Riverfront

638 Madison Ave, Covington, KY

Fully refundableReserve now, pay when you stay

$229 nightly

$257 total

Aug 21 - Aug 22

Total includes taxes and fees

This hotel features a restaurant and 2 bars/lounges. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and free airport ...

9.4/10 Exceptional! (1,010 reviews)

"Beautiful and clean! Art is outstanding in the hotel! Will stay again!"

Reviewed on Jul 21, 2025

Conrad Indianapolis

50 W Washington St., Indianapolis, IN

Fully refundableReserve now, pay when you stay

$218 nightly

$256 total

Aug 16 - Aug 17

Total includes taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,001 reviews)

"Great location right near the Fieldhouse, staff were great, room was very nice."

Reviewed on Jul 17, 2025

21c Museum Hotel Louisville

700 W Main Street, Louisville, KY

Fully refundableReserve now, pay when you stay

$125 nightly

$147 total

Aug 11 - Aug 12

Total includes taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (1,003 reviews)

"Fun hotel to stay at. I wanted a relaxing stay and that's what I got. TV in room kept freezing up so I ended up watching things from my laptop, but otherwise room was perfect for my needs."

Reviewed on Jul 21, 2025

The Brown Hotel

335 W Broadway, Louisville, KY

Fully refundableReserve now, pay when you stay

$179 nightly

$211 total

Jul 27 - Jul 28

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,033 reviews)

"The hotel itself is historic and so beautiful. We ate at both restaurants during our stay and had great experiences. The rooms were clean but had a very moist, damp feel throughout the stay. They could use some updating to the fixtures, painting, etc. Rhe bed was very firm but my husband was very ..."

Reviewed on Jul 21, 2025

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street, Louisville, KY

Fully refundableReserve now, pay when you stay

$129 nightly

$152 total

Aug 10 - Aug 11

Total includes taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

8.8/10 Excellent! (3,464 reviews)

"Prompt and friendly response to all questions."

Reviewed on Jul 20, 2025

21c Museum Hotel Cincinnati

609 Walnut St, Cincinnati, OH

Fully refundableReserve now, pay when you stay

$165 nightly

$197 total

Aug 3 - Aug 4

Total includes taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...

8.6/10 Excellent! (1,008 reviews)

"Relaxing and clean"

Reviewed on Jul 22, 2025

The Cincinnatian Hotel Curio Collection by Hilton

601 Vine Street, Cincinnati, OH

Fully refundableReserve now, pay when you stay

$147 nightly

$175 total

Aug 24 - Aug 25

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

7.6/10 Good! (1,003 reviews)

"Downtown and close to so much!"

Reviewed on Jul 19, 2025

West Baden Springs Hotel

8538 W Baden Ave, West Baden Springs, IN

This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...

"The hotel West Baden is awesome they have 24 hour trolley that runs every 15 minutes and will take you anywhere in the area."

Reviewed on Dec 25, 2018

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More 4 star hotels in Ohio River Valley

The Blackwell Inn and Pfahl Conference Center

2110 Tuttle Park Pl, Columbus, OH

$138 nightly

$163 total

Jul 27 - Jul 28

Total includes taxes and fees

9.4/10 Exceptional! (1,131 reviews)

5 star hotels in Ohio River Valley

Louisville Bourbon Inn

1332 S 4th St, Louisville, KY

$265 nightly

$308 total

Jul 26 - Jul 27

Total includes taxes and fees

10/10 Exceptional! (16 reviews)

Ohio River Valley Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Ohio River Valley luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Ohio River Valley to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Ohio River Valley will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Ohio River Valley, and plan your next opulent escape.

Ohio River Valley hotels essential information

Accommodation	19,387 hotels
Lowest Price	$105
Highest Price	$318
Popular hotels	Conrad Indianapolis, 21c Museum Hotel Louisville, West Baden Springs Hotel, 21c Museum Hotel Cincinnati, The Cincinnatian Hotel Curio Collection by Hilton, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Hotel Covington Cincinnati Riverfront

Popular Luxury Stays in Ohio River Valley

5 Stars Luxury stays in Ohio River Valley

Luxury stays in Ohio River Valley with spa

Recent Ohio River Valley Hotel Reviews By Fellow Wanderers

Crowne Plaza Louisville Airport Expo Ctr by IHG

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"Great experience. Very big and busy hotel but had a great experience. Hotel smelled great. The staff was very friendly and kind. The beds and pillows were so comfy. I would definitely recommend this hotel and I would love to stay here again. "

A verified traveler stayed at Crowne Plaza Louisville Airport Expo Ctr by IHG

Sheraton Indianapolis City Centre Hotel

5 out of 5

Posted 4 days ago

Travelocity Verified Review

"The Sheraton is having some repair or renovation work done so there were large metal pipes that make tge libby area very dark and it feels cramped our bedroom was grat. Thw beds comfortable. There was some noise at night from revving cars. Overall the room was comfortable "

A verified traveler stayed at Sheraton Indianapolis City Centre Hotel