Explore 14 Luxury Hotels in Mesopotamia

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Best Luxury Hotels in Mesopotamia

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR
$848 nightly
The price is $887 total per night from Jan 17 to Jan 18
$887 total
Jan 17 - Jan 18, 2026
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...
9.8/10 Exceptional! (1,001 reviews)
This place was excellent from the check in, to the room, food, and you just can’t beat the view! Access to the park before opening hours is absolutely also worth every penny. I would recommend this hotel to anyone wanting to stay at the falls,

Reviewed on Dec 10, 2025

Opens in a new windowHotel das Cataratas, A Belmond Hotel, Iguassu Falls
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$828 nightly
The price is $834 total per night from Jan 18 to Jan 19
$834 total
Jan 18 - Jan 19, 2026
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9.2/10 Wonderful! (1,001 reviews)
I real 5 star hotel in every way with stunning views and the huge added a bunch of being inside the national park so you could walk down to the trails highly highly recommend recommended

Reviewed on Dec 19, 2025

Opens in a new windowGran Melia Iguazú
Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$336 nightly
The price is $342 total per night from Jan 4 to Jan 5
$342 total
Jan 4 - Jan 5, 2026
This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...
9/10 Wonderful! (591 reviews)
Nice stay overall. Breakfast options limited for vegetarians. Friendly staff but it can be challenging to communicate if you don't speak Spanish. Fabio at the Concierge was most helpful and courteous, giving us excellent tips to get around area. The taxi service used by the hotel is also very good, ...

Reviewed on Dec 20, 2025

Opens in a new windowIguazu Grand Resort Spa & Casino
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Selva Iriapu Sin Numero Puerto Iguazú Misiones
$326 nightly
The price is $332 total per night from Jan 15 to Jan 16
$332 total
Jan 15 - Jan 16, 2026
A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,002 reviews)
Lovely hotel and installations. Food was well priced and decent. The rooms were beautiful, we were even allowed a courtesy room after having checked out for a quick shower after having visited the Falls and before our late evening flight. 100% recommend.

Reviewed on Dec 18, 2025

Opens in a new windowLoi Suites Iguazú Hotel
Hotel Saint George

Hotel Saint George

Avenida Cordoba 148 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $133 total per night from Dec 24 to Dec 25
$133 total
Dec 24 - Dec 25
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Enjoy the gym and free perks like buffet breakfast and WiFi ...
8.6/10 Excellent! (1,002 reviews)
The pool area was the highlight of the hotel. The rooms were comfortable. There was a bit of maintenance going on around the hotel.

Reviewed on Dec 18, 2025

Opens in a new windowHotel Saint George
Panoramic Grand

Panoramic Grand

Av. Córdoba y Félix de Azara Puerto Iguazú Misiones
A full-service spa, a gym, and a restaurant are all featured at this Colonial hotel. Families will appreciate the children's pool, kid-friendly dining, and in-room ...
8.6/10 Excellent! (633 reviews)
It was good

Reviewed on Dec 1, 2025

Opens in a new windowPanoramic Grand
La Reserva Virgin Lodge

La Reserva Virgin Lodge

Ruta 12 km 5 Puerto Iguazú Misiones
This smoke-free hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax ...
8.4/10 Very Good! (802 reviews)
We had a great time, front desk staff were very helpful, they helped us schedule transportation to/from the airport, as well as a round trip driver to Iguazu Falls. The breakfast and dinner were great, and our rooms were clean. A great place to stay if you want to feel like you are in nature.

Reviewed on Nov 24, 2025

Opens in a new windowLa Reserva Virgin Lodge
Marcopolo Suites Iguazu

Marcopolo Suites Iguazu

Ruta 12 Km 3,50 - Puerto Iguazu Puerto Iguazú Misiones
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like buffet breakfast and free ...
6.6/10 (319 reviews)
No
Estadia linda, solo detalles como falta de secador en el baño, tv mas moderno.

Reviewed on Apr 22, 2025

Opens in a new windowMarcopolo Suites Iguazu
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More 4 star hotels in Mesopotamia

5 star hotels in Mesopotamia

Bagú Urbano

Bagú Urbano

Bolivar 2176 Posadas Misiones
8.4/10 Very Good! (343 reviews)

Mesopotamia Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mesopotamia luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mesopotamia to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mesopotamia will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mesopotamia, and plan your next opulent escape.


Mesopotamia hotels essential information

Accommodation
491 hotels
Lowest Price
$51
Highest Price
$887
Popular hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazu Grand Resort Spa & Casino, Gran Melia Iguazú, Loi Suites Iguazú Hotel, La Reserva Virgin Lodge, Hotel Saint George, Panoramic Grand, Marcopolo Suites Iguazu

Popular Luxury Stays in Mesopotamia