Explore 14 Luxury Hotels in Mesopotamia

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Best Luxury Hotels in Mesopotamia

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32, Iguassu National Park, Foz do Iguaçu, PR
Fully refundableReserve now, pay when you stay
$727 nightly
The price is $760 total per night from Jun 6 to Jun 7
$760 total
Jun 6 - Jun 7
Total includes taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...
9.8/10 Exceptional! (1,003 reviews)
"Wonderful hotel location and very nice staff"

Reviewed on Jun 1, 2025

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$299 nightly
The price is $299 total per night from Jun 6 to Jun 7
$299 total
Jun 6 - Jun 7
This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...
9/10 Wonderful! (544 reviews)
"Great staff!"

Reviewed on May 27, 2025

Iguazu Grand Resort Spa & Casino
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$390 nightly
The price is $394 total per night from Jun 10 to Jun 11
$394 total
Jun 10 - Jun 11
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,005 reviews)
"Hotel's location inside the national park is perfect. Matching up to a 5star hotel. Service is excellent. Breakfast is the best. we enjoyed our 3 nights stay very much"

Reviewed on Jun 4, 2025

Gran Melia Iguazú
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Selva Iriapu Sin Numero, Casilla de Correo 11, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $361 total per night from Jun 7 to Jun 8
$361 total
Jun 7 - Jun 8
A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (999 reviews)
"Hotel in the middle of the jungle! Not walkable but totally worth it. Gorgeous hotel, instagramable open spaces, pleasant staff, good breakfast, great spa and beautiful pool. Rooms are large with scenic balcony but…. Bed not too comfortable and weird smell. Nevertheless, I give it 5 starts!"

Reviewed on May 26, 2025

Loi Suites Iguazú Hotel
Hotel Saint George

Hotel Saint George

Avenida Cordoba 148, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $83 total per night from Jun 24 to Jun 25
$83 total
Jun 24 - Jun 25
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Enjoy the gym and free perks like buffet breakfast and WiFi ...
8.6/10 Excellent! (999 reviews)
"Great spot for couples!"

Reviewed on Jun 3, 2025

Hotel Saint George
Panoramic Grand

Panoramic Grand

Av. Córdoba y Félix de Azara, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $239 total per night from Jun 6 to Jun 7
$239 total
Jun 6 - Jun 7
A full-service spa, a gym, and a restaurant are all featured at this Colonial hotel. Families will appreciate the children's pool, kid-friendly dining, and in-room ...
8.6/10 Excellent! (618 reviews)
"Wow staff were helpful and friendly they made the stay great!"

Reviewed on Apr 30, 2025

Panoramic Grand
La Reserva Virgin Lodge

La Reserva Virgin Lodge

Ruta 12 km 5, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $112 total per night from Jun 9 to Jun 10
$112 total
Jun 9 - Jun 10
This smoke-free hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax ...
8.4/10 Very Good! (784 reviews)
"Very nice hotel and it’s so peaceful! The pool is lovely and the restaurant for breakfast was so good! Easy to travel to the waterfalls and the town of Iguazu is a short drive away. Highly recommend"

Reviewed on Apr 5, 2025

La Reserva Virgin Lodge
Marcopolo Suites Iguazu

Marcopolo Suites Iguazu

Ruta 12 Km 3,50 - Puerto Iguazu, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $66 total per night from Jun 6 to Jun 7
$66 total
Jun 6 - Jun 7
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like buffet breakfast and free ...
6.6/10 (318 reviews)
No
"Estadia linda, solo detalles como falta de secador en el baño, tv mas moderno."

Reviewed on Apr 22, 2025

Marcopolo Suites Iguazu
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More 4 star hotels in Mesopotamia

5 star hotels in Mesopotamia

Bagú Urbano

Bagú Urbano

Bolivar 2176, Posadas, Misiones
8.4/10 Very Good! (334 reviews)

Mesopotamia Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mesopotamia luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mesopotamia to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mesopotamia will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mesopotamia, and plan your next opulent escape.


Mesopotamia hotels essential information

Accommodation
452 hotels
Lowest Price
$66
Highest Price
$760
Popular hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazu Grand Resort Spa & Casino, Gran Melia Iguazú, Loi Suites Iguazú Hotel, La Reserva Virgin Lodge, Hotel Saint George, Panoramic Grand, Marcopolo Suites Iguazu

Popular Luxury Stays in Mesopotamia

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