Explore 14 Luxury Hotels in Mesopotamia

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Best Luxury Hotels in Mesopotamia

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR
Fully refundableReserve now, pay when you stay
$777 nightly
The price is $826 total per night from Jun 13 to Jun 14
$826 total
Jun 13 - Jun 14
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...
9.8/10 Exceptional! (1,016 reviews)
"Although this hotel came at a price! We can't say enough great things about it! We splurged and had the ground floor room with our own pool. Omg the room was amazing! We were greeted personal with drinks, candy and hot towels to freshen up! Our room was ready early and we were personally taken there ..."

Reviewed on Jun 10, 2026

Opens in a new windowHotel das Cataratas, A Belmond Hotel, Iguassu Falls
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$644 nightly
The price is $653 total per night from Jun 12 to Jun 13
$653 total
Jun 12 - Jun 13
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this luxury hotel. Traveling on business? Take advantage of the business center and ...
9.4/10 Exceptional! (1,006 reviews)
"Amazing place! Small tips: - I would not recommend to book the waterfall view. Yes, the view is spectacular, but humidity is not acceptable. Jungle view is much better. - Second and third floors was renovated, first floor is not as fresh as other areas. But still good! - Book your stay with the half ..."

Reviewed on Jun 8, 2026

Opens in a new windowGran Melia Iguazú
Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$294 nightly
The price is $303 total per night from Jun 12 to Jun 13
$303 total
Jun 12 - Jun 13
This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...
9.2/10 Wonderful! (664 reviews)
"5-star property with well-maintained lush garden and pool and amazing staff. Special kudos to front desk staff (David and Gabriel), porters (Bruno and Gonzalo) and concierge (Fabio). Very satisfied with our 2-night stays."

Reviewed on May 30, 2026

Opens in a new windowIguazu Grand Resort Spa & Casino
Hotel Saint George

Hotel Saint George

Avenida Cordoba 148 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $107 total per night from Jun 22 to Jun 23
$107 total
Jun 22 - Jun 23
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Enjoy the gym and free perks like buffet breakfast and WiFi ...
9/10 Wonderful! (1,010 reviews)
"Great hotel and location, with a wonderful breakfast!"

Reviewed on Jun 8, 2026

Opens in a new windowHotel Saint George
La Reserva Virgin Lodge

La Reserva Virgin Lodge

Ruta 12 km 5 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $99 total per night from Jun 23 to Jun 24
$99 total
Jun 23 - Jun 24
This smoke-free hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax ...
8.6/10 Excellent! (826 reviews)
"Thank you! We had a great time, highly recommend."

Reviewed on May 31, 2026

Opens in a new windowLa Reserva Virgin Lodge
Marcopolo Suites Iguazu

Marcopolo Suites Iguazu

Ruta 12 Km 3,50 - Puerto Iguazu Puerto Iguazú Misiones
$46 nightly
The price is $51 total per night from Jun 25 to Jun 26
$51 total
Jun 25 - Jun 26
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like buffet breakfast and free ...
6.6/10 (328 reviews)
"It’s was good . The staff friendly, the place clean. The food excellent. La parrillada ufff delicious. The pool nice close to attractions. Definitely highly recommended."

Reviewed on Apr 7, 2026

Opens in a new windowMarcopolo Suites Iguazu
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Selva Iriapu Sin Numero Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$349 nightly
The price is $358 total per night from Jun 12 to Jun 13
$358 total
Jun 12 - Jun 13
A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
Opens in a new windowLoi Suites Iguazú Hotel
Panoramic Grand

Panoramic Grand

Av. Córdoba y Félix de Azara Puerto Iguazú Misiones
A full-service spa, a gym, and a restaurant are all featured at this Colonial hotel. Families will appreciate the children's pool, kid-friendly dining, and in-room ...
Opens in a new windowPanoramic Grand
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More 4 star hotels in Mesopotamia

5 star hotels in Mesopotamia

Bagú Urbano

Bagú Urbano

Bolivar 2176 Posadas Misiones

Mesopotamia Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mesopotamia luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mesopotamia to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mesopotamia will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mesopotamia, and plan your next opulent escape.


Mesopotamia hotels essential information

Accommodation
524 hotels
Lowest Price
$51
Highest Price
$826
Popular hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazu Grand Resort Spa & Casino, Gran Melia Iguazú, Loi Suites Iguazú Hotel, La Reserva Virgin Lodge, Hotel Saint George, Panoramic Grand, Marcopolo Suites Iguazu

Popular Luxury Stays in Mesopotamia