Explore 14 Luxury Hotels in Mesopotamia

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Best Luxury Hotels in Mesopotamia

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32, Iguassu National Park, Foz do Iguaçu, PR
Fully refundableReserve now, pay when you stay
$838 nightly
The price is $876 total per night from Nov 7 to Nov 8
$876 total
Nov 7 - Nov 8
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...
9.8/10 Exceptional! (1,027 reviews)
Fantastic

Reviewed on Oct 31, 2025

Opens in a new windowHotel das Cataratas, A Belmond Hotel, Iguassu Falls
Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$369 nightly
The price is $375 total per night from Nov 3 to Nov 4
$375 total
Nov 3 - Nov 4
This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...
9/10 Wonderful! (572 reviews)
Spacious room, great amenities

Reviewed on Oct 21, 2025

Opens in a new windowIguazu Grand Resort Spa & Casino
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$608 nightly
The price is $614 total per night from Dec 1 to Dec 2
$614 total
Dec 1 - Dec 2
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,007 reviews)
N/a

Reviewed on Oct 31, 2025

Opens in a new windowGran Melia Iguazú
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Selva Iriapu Sin Numero, Casilla de Correo 11, Puerto Iguazú, Misiones
$319 nightly
The price is $325 total per night from Nov 14 to Nov 15
$325 total
Nov 14 - Nov 15
A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (999 reviews)
Clean rooms, great food and

Reviewed on Oct 12, 2025

Opens in a new windowLoi Suites Iguazú Hotel
Hotel Saint George

Hotel Saint George

Avenida Cordoba 148, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $127 total per night from Nov 24 to Nov 25
$127 total
Nov 24 - Nov 25
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Enjoy the gym and free perks like buffet breakfast and WiFi ...
8.6/10 Excellent! (1,005 reviews)
Servicio excelente

Reviewed on Oct 25, 2025

Opens in a new windowHotel Saint George
Panoramic Grand

Panoramic Grand

Av. Córdoba y Félix de Azara, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $292 total per night from Dec 1 to Dec 2
$292 total
Dec 1 - Dec 2
A full-service spa, a gym, and a restaurant are all featured at this Colonial hotel. Families will appreciate the children's pool, kid-friendly dining, and in-room ...
8.6/10 Excellent! (624 reviews)
AWESOME EXPERIENCE!!

Reviewed on Sep 11, 2025

Opens in a new windowPanoramic Grand
La Reserva Virgin Lodge

La Reserva Virgin Lodge

Ruta 12 km 5, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
This smoke-free hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax ...
8.4/10 Very Good! (794 reviews)
Good breakfast, lots of places to sit and enjoy the day, good pool and attentive staff!

Reviewed on Oct 25, 2025

Opens in a new windowLa Reserva Virgin Lodge
Marcopolo Suites Iguazu

Marcopolo Suites Iguazu

Ruta 12 Km 3,50 - Puerto Iguazu, Puerto Iguazú, Misiones
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like buffet breakfast and free ...
6.6/10 (319 reviews)
No
Estadia linda, solo detalles como falta de secador en el baño, tv mas moderno.

Reviewed on Apr 22, 2025

Opens in a new windowMarcopolo Suites Iguazu
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Mesopotamia

5 star hotels in Mesopotamia

Bagú Urbano

Bagú Urbano

Bolivar 2176, Posadas, Misiones
8.4/10 Very Good! (343 reviews)

Mesopotamia Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mesopotamia luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mesopotamia to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mesopotamia will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mesopotamia, and plan your next opulent escape.


Mesopotamia hotels essential information

Accommodation
493 hotels
Lowest Price
$54
Highest Price
$876
Popular hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazu Grand Resort Spa & Casino, Gran Melia Iguazú, Loi Suites Iguazú Hotel, La Reserva Virgin Lodge, Hotel Saint George, Panoramic Grand, Marcopolo Suites Iguazu

Popular Luxury Stays in Mesopotamia