Explore 14 Luxury Hotels in Mesopotamia

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Best Luxury Hotels in Mesopotamia

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR
Fully refundableReserve now, pay when you stay
$887 nightly
The price is $943 total per night from Nov 12 to Nov 13
$943 total
Nov 12 - Nov 13
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...
10/10 Exceptional! (1,005 reviews)
"The hotel is beautiful and the service was outstanding. The hotel is located across the street from the Falls on the Brazil side and the view is amazing!"

Reviewed on Nov 1, 2026

Opens in a new windowHotel das Cataratas, A Belmond Hotel, Iguassu Falls
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$743 nightly
The price is $752 total per night from Dec 6 to Dec 7
$752 total
Dec 6 - Dec 7
A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free ...
9.4/10 Exceptional! (1,005 reviews)
"Over my 20+ years of business trips and vacations, this was probably one of the best hotels I ever stayed in. Everything is top-notch - amenities, restaurants, staff, rooms. I’m very glad I found this hotel when I searched where to stay during our visit to Iguazu Falls. Definitely recommend to everyone ..."

Reviewed on Nov 4, 2026

Opens in a new windowGran Melia Iguazú
Iguazú Grand Hotel

Iguazú Grand Hotel

Route 12 Km 1640 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $262 total per night from Dec 6 to Dec 7
$262 total
Dec 6 - Dec 7
This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...
9.2/10 Wonderful! (700 reviews)
"The property was good and most folks were welcoming and helpful the WiFi was strange and one of my laptop couldn’t linkup and one of the staff refused to make us an extra key"

Reviewed on Oct 26, 2026

Opens in a new windowIguazú Grand Hotel
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Selva Iriapu Sin Numero Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$374 nightly
The price is $383 total per night from Nov 9 to Nov 10
$383 total
Nov 9 - Nov 10
A full-service spa, 2 restaurants, and 2 outdoor pools are all featured at this luxury resort. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,000 reviews)
"The place is nice enough. Unless you are an infant, you'll probably die of old age waiting for your food or drink orders to be filled. Breakfasts are good. The breakfast food quality is acceptable and it's buffet style, so you don't have to wait on the server to bring you the food. If you want a ..."

Reviewed on Oct 30, 2026

Opens in a new windowLoi Suites Iguazú Hotel
La Reserva Virgin Lodge

La Reserva Virgin Lodge

Ruta 12 km 5 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $117 total per night from Dec 4 to Dec 5
$117 total
Dec 4 - Dec 5
This smoke-free hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax ...
8.4/10 Very Good! (840 reviews)
"This place offers a unique experience. Surrounded by trees we enjoyed the quietness of the forest. The restaurant serves a great variety of delicious food and the staff is super friendly. The rooms we got were a little bit outdated. Overall we had a good experience here,"

Reviewed on Oct 27, 2026

Opens in a new windowLa Reserva Virgin Lodge
Marcopolo Suites Iguazu

Marcopolo Suites Iguazu

Ruta 12 Km 3,50 - Puerto Iguazu Puerto Iguazú Misiones
$49 nightly
The price is $53 total per night from Nov 9 to Nov 10
$53 total
Nov 9 - Nov 10
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like buffet breakfast and free ...
6.6/10 (331 reviews)
"It’s was good . The staff friendly, the place clean. The food excellent. La parrillada ufff delicious. The pool nice close to attractions. Definitely highly recommended."

Reviewed on Apr 7, 2026

Opens in a new windowMarcopolo Suites Iguazu
Hotel Saint George

Hotel Saint George

Avenida Cordoba 148 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $138 total per night from Dec 4 to Dec 5
$138 total
Dec 4 - Dec 5
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Enjoy the gym and free perks like buffet breakfast and WiFi ...
Opens in a new windowHotel Saint George
Panoramic Grand Hotel

Panoramic Grand Hotel

Av. Córdoba y Félix de Azara Puerto Iguazú Misiones
A full-service spa, a gym, and a restaurant are all featured at this Colonial hotel. Families will appreciate the children's pool, kid-friendly dining, and in-room ...
Opens in a new windowPanoramic Grand Hotel
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More 4 star hotels in Mesopotamia

5 star hotels in Mesopotamia

Bagú Urbano

Bagú Urbano

Bolivar 2176 Posadas Misiones

Mesopotamia Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Mesopotamia luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Mesopotamia to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Mesopotamia will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Mesopotamia, and plan your next opulent escape.


Mesopotamia hotels essential information

Accommodation
532 hotels
Lowest Price
$53
Highest Price
$943
Popular hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazú Grand Hotel, Gran Melia Iguazú, Loi Suites Iguazú Hotel, La Reserva Virgin Lodge, Hotel Saint George, Panoramic Grand Hotel, Marcopolo Suites Iguazu

Popular Luxury Stays in Mesopotamia