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Top hotels in Lake Nona Medical City

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $280 total per night from Apr 26 to Apr 27
$280 total
Apr 26 - Apr 27
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Families will appreciate the onsite laundry facilities, kid-friendly dining, ...
Staff was very helpful especially valet staff

Reviewed on Apr 14, 2026

Opens in a new windowHyatt Regency Orlando International Airport
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

3 out of 5
7491 W Irlo Bronson Memorial Hwy Kissimmee FL
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $93 total per night from Apr 19 to Apr 20
$93 total
Apr 19 - Apr 20
Total with taxes and fees
2 hot tubs, an outdoor pool, and a 24-hour gym are all featured at this smoke-free resort. Enjoy the sauna and free perks like buffet breakfast and WiFi in public ...
Breakfast was fresh, shrimp tacos amazing! Enjoyed a relaxing day in the lazy river.

Reviewed on Apr 16, 2026

Opens in a new windowKompose Boutique Resort at Theme Parks
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from May 11 to May 12
$125 total
May 11 - May 12
Total with taxes and fees
This smoke-free aparthotel features 3 restaurants, 6 outdoor pools, and 10 outdoor tennis courts. There's fun for all ages with a free kid's club and mini golf, ...
Very clean

Reviewed on Apr 16, 2026

Opens in a new windowSheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way Orlando FL
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $150 total per night from May 3 to May 4
$150 total
May 3 - May 4
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and 2 hot tubs. There's fun for all ages with a lazy river and a bowling alley, and families will ...
This was the perfect stay for the family thanks to the staff member Joshua who upgraded our suite to a pool view for my son birthday. The staff was nice and welcoming we will be planning to come back!

Reviewed on Apr 16, 2026

Opens in a new windowUniversal's Cabana Bay Beach Resort
Marriott's Grande Vista

Marriott's Grande Vista

4 out of 5
5925 Avenida Vista Orlando FL
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $156 total per night from Apr 26 to Apr 27
$156 total
Apr 26 - Apr 27
Total with taxes and fees
This smoke-free aparthotel features a golf course, a full-service spa, and 3 restaurants. There's fun for all ages with mini golf and a children's pool, and ...
Exceeded my expectations in every way!!

Reviewed on Apr 16, 2026

Opens in a new windowMarriott's Grande Vista
Rosen Inn at Pointe Orlando

Rosen Inn at Pointe Orlando

3 out of 5
9000 International Drive Orlando FL
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Apr 27 to Apr 28
$100 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel features 3 outdoor pools, a gym, and a restaurant. Bring the family and enjoy the free theme park shuttle, playground, and kid-friendly dining. Enjoy ...
Room was clean, well made up, beds are comfy. A/C was working a treat and much needed too. Cleaners were friendly and thorough, loads of storage space. Shower over the bath was a bit week and worn but it worked perfectly well every time and thats what you need. All in all a very pleasent stay If ...

Reviewed on Apr 16, 2026

Opens in a new windowRosen Inn at Pointe Orlando
Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

4 out of 5
9500 Turkey Lake Rd Orlando FL
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $143 total per night from Apr 26 to Apr 27
$143 total
Apr 26 - Apr 27
Total with taxes and fees
This smoke-free hotel features a full-service spa, a water park, and a marina. There's fun for all ages with mini golf and a children's pool, and barbecue grills ...
The air conditioning didn’t work correctly in our room and couldn’t be adjusted and our blinds were broken and couldn’t fully shut. When the maintenance man came, he fixed the blinds but acted flustered about the thermostat not working correctly and just left the room saying an HVAC guy will have ...

Reviewed on Apr 16, 2026

Opens in a new windowWestgate Lakes Resort & Spa Universal Studios Area
Coco Key Hotel & Water Park Resort

Coco Key Hotel & Water Park Resort

3.5 out of 5
7400 International Dr Orlando FL
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $158 total per night from Apr 20 to Apr 21
$158 total
Apr 20 - Apr 21
Total with taxes and fees
Free water park access, 4 restaurants, and 3 outdoor pools are all featured at this traditional hotel. There's fun for all ages with mini golf and a children's ...
Room was clean, really wish the indoor water area opened earlier as we paid resort fees but the kids only got two hours total to play. First night we had no water so no working toilet, shower, etc. Staff was very nice, but our overall experience wasn’t what I expected. Might give it a second chance ...

Reviewed on Apr 16, 2026

Opens in a new windowCoco Key Hotel & Water Park Resort
Holiday Inn Resort Orlando Suites - Waterpark by IHG

Holiday Inn Resort Orlando Suites - Waterpark by IHG

3.5 out of 5
18000 International Dr S. Orlando FL
Fully refundable
$112 nightly
The price is $126 total per night from May 17 to May 18
$126 total
May 17 - May 18
Total with taxes and fees
Free water park access, 5 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. There's fun for all ages with a children's pool and a waterslide, ...
Pool area under construction and work started a 7am and no one made us aware of such a early start time definitely was disappointed

Reviewed on Apr 16, 2026

Opens in a new windowHoliday Inn Resort Orlando Suites - Waterpark by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Lake Nona Medical City Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

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Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Lake Nona Medical City are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

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