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Top hotels in Lake Nona Medical City

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $148 total per night from Mar 22 to Mar 23
$148 total
Mar 22 - Mar 23
Total with taxes and fees
This smoke-free condo resort features 3 restaurants, 6 outdoor pools, and 10 outdoor tennis courts. There's fun for all ages with a free kid's club and mini ...
Been Staying at this resort for years . Never seems to disappoint. Staff was extremely helpful and friendly. Grounds, common areas and our villa was extremely clean. Has been updated since our last stay. Love this property it has so much to do without leaving the grounds . Games and activities for ...

Reviewed on Mar 1, 2026

Opens in a new windowSheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way Orlando FL
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $167 total per night from Mar 10 to Mar 11
$167 total
Mar 10 - Mar 11
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and 2 hot tubs. There's fun for all ages with a lazy river and a bowling alley, and families will ...
It was a clean place. Food was ok. My room key and the replacement I got only worked for our room. It did not work for any of the gates or pool area. Bowling area is very expensive and it would have been nice for the charges to be disclosed. Phone in the room didn’t work. The family suite was set ...

Reviewed on Mar 1, 2026

Opens in a new windowUniversal's Cabana Bay Beach Resort
Marriott's Grande Vista

Marriott's Grande Vista

4 out of 5
5925 Avenida Vista Orlando FL
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $161 total per night from Mar 22 to Mar 23
$161 total
Mar 22 - Mar 23
Total with taxes and fees
This smoke-free condo resort features a golf course, a full-service spa, and 3 restaurants. There's fun for all ages with mini golf and a children's pool, and ...
I loved everything about it, the only problem was that I was only staying for the night( wish it was a week).

Reviewed on Mar 1, 2026

Opens in a new windowMarriott's Grande Vista
Vacation Village Orlando, Celebration

Vacation Village Orlando, Celebration

3 out of 5
2975 Arabian Nights Blvd Kissimmee FL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $126 total per night from Mar 2 to Mar 3
$126 total
Mar 2 - Mar 3
Total with taxes and fees
7 outdoor pools, 7 hot tubs, and a gym are all featured at this smoke-free condo. Bring the family and enjoy the children's pool, playground, and arcade/game ...
Just perfect.

Reviewed on Mar 1, 2026

Opens in a new windowVacation Village Orlando, Celebration
Rosen Inn Lake Buena Vista

Rosen Inn Lake Buena Vista

3.5 out of 5
8442 Palm Parkway Orlando FL
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $88 total per night from Mar 8 to Mar 9
$88 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Bring the family and enjoy the children's pool, free theme park shuttle, and playground. ...
Clean room, nice staff, pretty grounds, central location.

Reviewed on Mar 1, 2026

Opens in a new windowRosen Inn Lake Buena Vista
Rosen Inn at Pointe Orlando

Rosen Inn at Pointe Orlando

3 out of 5
9000 International Drive Orlando FL
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $110 total per night from Mar 8 to Mar 9
$110 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features 3 outdoor pools, a gym, and a restaurant. Bring the family and enjoy the free theme park shuttle, playground, and kid-friendly dining. Enjoy ...
La habitación estaba limpia, nos gustó mucho la ubicación.

Reviewed on Mar 1, 2026

Opens in a new windowRosen Inn at Pointe Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4 out of 5
5780 Major Blvd Orlando FL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $119 total per night from Mar 30 to Mar 31
$119 total
Mar 30 - Mar 31
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. There's fun for all ages with a children's pool and an arcade/game room, and ...
Great stay, even better location! Staff were very nice, and the Universal desk was an added bonus we didn’t realize!

Reviewed on Mar 1, 2026

Opens in a new windowDoubleTree by Hilton at the Entrance to Universal Orlando
Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

4 out of 5
9500 Turkey Lake Rd Orlando FL
This smoke-free hotel features a full-service spa, a water park, and a marina. There's fun for all ages with a lazy river and a children's club, and barbecue ...
This was our second stay at Westgate Lakes Resort & Spa and we had another great time. Staff is very responsive and accommodating if you need anything. Room was clean and comfortable. We look forward to going back again

Reviewed on Mar 1, 2026

Opens in a new windowWestgate Lakes Resort & Spa Universal Studios Area
Orlando International Drive North Hotel

Orlando International Drive North Hotel

2 out of 5
5859 American Way Orlando FL
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $84 total per night from Mar 31 to Apr 1
$84 total
Mar 31 - Apr 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. There's fun for all ages with a theme park shuttle and a playground. There's no skimping ...
Everything was what i expected great stay

Reviewed on Mar 1, 2026

Opens in a new windowOrlando International Drive North Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Lake Nona Medical City Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Lake Nona Medical City area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Lake Nona Medical City to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Lake Nona Medical City are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

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