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Top hotels in Lake Nona Medical City

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
$187 nightly
The price is $210 total per night from Aug 3 to Aug 4
$210 total
Aug 3 - Aug 4
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free ...
"Ok"

Reviewed on Jul 14, 2026

Opens in a new windowHyatt Regency Orlando International Airport
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $154 total per night from Aug 4 to Aug 5
$154 total
Aug 4 - Aug 5
Total with taxes and fees
This smoke-free aparthotel features 3 restaurants, 6 outdoor pools, and 10 outdoor tennis courts. There's fun for all ages with a free kid's club and mini golf, ...
"I was very happy with my stay and the staff there were very helpful and nice to deal with."

Reviewed on Jul 14, 2026

Opens in a new windowSheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Universal's Endless Summer Resort - Dockside Inn and Suites

Universal's Endless Summer Resort - Dockside Inn and Suites

3 out of 5
7125 Universal Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $142 total per night from Aug 11 to Aug 12
$142 total
Aug 11 - Aug 12
Total with taxes and fees
This smoke-free hotel features 2 outdoor pools, a gym, and a restaurant. Bring the family and enjoy the children's pool, early theme park entry, and arcade/game ...
"Carpets on hallways was dirty"

Reviewed on Jul 14, 2026

Opens in a new windowUniversal's Endless Summer Resort - Dockside Inn and Suites
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

4 out of 5
12401 International Dr Orlando FL
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $134 total per night from Aug 9 to Aug 10
$134 total
Aug 9 - Aug 10
Total with taxes and fees
This smoke-free aparthotel features 2 restaurants, 5 outdoor pools, and 2 outdoor tennis courts. Bring the family and enjoy the children's club, children's pool, ...
"The resort was good, and the location was very good. My room smelled a little off but I didn’t complain because we only stayed there one night."

Reviewed on Jul 13, 2026

Opens in a new windowSheraton Vistana Villages Resort Villas, I-Drive/Orlando
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way Orlando FL
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $169 total per night from Jul 20 to Jul 21
$169 total
Jul 20 - Jul 21
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and 2 hot tubs. There's fun for all ages with a lazy river and a bowling alley, and families will ...
"The property is dated and somewhat dingy. It wasn’t what I expected for a Universal property. It was adequate for our needs, but I wouldn’t stay again. The check in process took over an hour."

Reviewed on Jul 14, 2026

Opens in a new windowUniversal's Cabana Bay Beach Resort
Marriott's Grande Vista

Marriott's Grande Vista

4 out of 5
5925 Avenida Vista Orlando FL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Aug 4 to Aug 5
$125 total
Aug 4 - Aug 5
Total with taxes and fees
This smoke-free aparthotel features a golf course, a full-service spa, and 3 restaurants. There's fun for all ages with mini golf and a children's pool, and ...
"This is my second time here and I love it. Everything was clean is great for families."

Reviewed on Jul 14, 2026

Opens in a new windowMarriott's Grande Vista
Walt Disney World Dolphin

Walt Disney World Dolphin

4 out of 5
1500 Epcot Resort Blvd Lake Buena Vista FL
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $237 total per night from Aug 1 to Aug 2
$237 total
Aug 1 - Aug 2
Total with taxes and fees
This smoke-free hotel features a private beach, a full-service spa, and 5 restaurants. There's fun for all ages with a children's club and a children's pool, ...
"I go to this property yearly…. Most staff I are friendly…. Location is terrific!"

Reviewed on Jul 14, 2026

Opens in a new windowWalt Disney World Dolphin
Rosen Inn Lake Buena Vista

Rosen Inn Lake Buena Vista

3.5 out of 5
8442 Palm Parkway Orlando FL
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $70 total per night from Aug 9 to Aug 10
$70 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Bring the family and enjoy the children's pool, free theme park shuttle, and playground. ...
"The rooms were clean the staff was really nice"

Reviewed on Jul 14, 2026

Opens in a new windowRosen Inn Lake Buena Vista
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4 out of 5
5780 Major Blvd Orlando FL
Fully refundable
$96 nightly
The price is $108 total per night from Jul 21 to Jul 22
$108 total
Jul 21 - Jul 22
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. There's fun for all ages with a children's pool and an arcade/game room, and ...
"Everything"

Reviewed on Jul 14, 2026

Opens in a new windowDoubleTree by Hilton at the Entrance to Universal Orlando
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Lake Nona Medical City Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Lake Nona Medical City area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Lake Nona Medical City to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Lake Nona Medical City are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Lake Nona Medical City hotel reviews by fellow wanderers

Rosen Inn Lake Buena Vista

Rosen Inn Lake Buena Vista

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The rooms were clean the staff was really nice"
A verified traveler stayed at Rosen Inn Lake Buena Vista
Rosen Inn Lake Buena Vista

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