Explore top 2026 5 Star Hotels in Syracuse

Name: Wellness & Spa Hotel Principe di Fitalia
Price range: $372 total
Rating: 9.4

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Top Syracuse 5 Star hotels

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR

Fully refundableReserve now, pay when you stay

$292 nightly

$332 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, 2 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR

Fully refundableReserve now, pay when you stay

$267 nightly

$304 total

Nov 9 - Nov 10

Total with taxes and fees

This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Take the beach shuttle and relax with sun loungers and beach umbrellas. WiFi in public ...

9/10 Wonderful! (635 reviews)

"A splendid, classic property with first rate service, comfortable beds and a glorious breakfast on a breathtaking outdoor terrace. Wish we could have stayed longer."

Reviewed on Oct 12, 2026

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR

Fully refundableReserve now, pay when you stay

$574 nightly

$643 total

Oct 29 - Oct 30

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...

Caportigia Boutique Hotel

Viale Montedoro 76 Syracuse SR

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Nov 5 - Nov 6

Total with taxes and fees

This hotel features a restaurant, a hot tub, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate ...

9.2/10 Wonderful! (300 reviews)

"Overall the hotel was very nice and in perfect location. We would definitely stay again. Some items they could improve. The reading lights above bed did not work and there was no other source of light except the huge lights for the entire room. The shower floor was super super super slippery. Both ..."

Reviewed on Sep 28, 2026

Dimora Caiammari Luxury Hotel & Spa

Via Daniele Impellizzeri Syracuse SR

Fully refundableReserve now, pay when you stay

$302 nightly

$343 total

Oct 25 - Oct 26

Total with taxes and fees

This luxury hotel features a full-service spa, 2 outdoor pools, and a restaurant. There's fun for all ages with a children's pool and a playground, and families ...

Minareto

Via del Faro Massolivieri 26 Syracuse SR

Fully refundableReserve now, pay when you stay

$247 nightly

$283 total

Nov 8 - Nov 9

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 2 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Families ...

8.8/10 Excellent! (281 reviews)

"One of the most beautiful and luxurious hotels I have ever visited—excellent and spotless. The views were picture-perfect, and the cleanliness and scents were wonderful. The amenities were top-notch, comprehensive, and high-quality, and the hotel facilities were excellent. Highly recommended."

Reviewed on Oct 8, 2026

Wellness & Spa Hotel Principe di Fitalia

Traversa Tonnara di Terrauzza 51 Syracuse SR

Fully refundableReserve now, pay when you stay

$328 nightly

$372 total

Nov 5 - Nov 6

Total with taxes and fees

An attached winery, a full-service spa, and 2 outdoor pools are all featured at this luxury hotel. There's fun for all ages with a children's club and a children's ...

9.4/10 Exceptional! (99 reviews)

"This is a unique property which is somewhat isolated but about 20 minutes from Syracusa and we were able to get an Uber pretty easily. We had a rental car and went to Arenella Beach which was great experience which I feel was a real authentic Sicily lido experience. We paid 5 euro for the parking ..."

Reviewed on Oct 11, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Syracuse

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.