Explore top 2025 5 Star Hotels in Syracuse

Name: Wellness & Spa Hotel Principe di Fitalia
Price range: $494 total
Rating: 9.4

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Top Syracuse 5 Star hotels

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR

Fully refundableReserve now, pay when you stay

$244 nightly

$280 total

Dec 2 - Dec 3

Total with taxes and fees

A full-service spa, 2 restaurants, and a 24-hour gym are all featured at this smoke-free property. Enjoy the sauna and perks like free WiFi. There's a bar/lounge ...

9.2/10 Wonderful! (250 reviews)

Excellent staff and lication

Reviewed on Nov 14, 2025

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR

Fully refundableReserve now, pay when you stay

$207 nightly

$240 total

Dec 25 - Dec 26

Total with taxes and fees

This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Take the beach shuttle and relax with sun loungers and beach umbrellas. WiFi in public ...

8.8/10 Excellent! (562 reviews)

breakfast was good

Reviewed on Nov 2, 2025

Caportigia Boutique Hotel

Viale Montedoro 76 Syracuse SR

Fully refundableReserve now, pay when you stay

$128 nightly

$153 total

Dec 3 - Dec 4

Total with taxes and fees

This property features a restaurant, a hot tub, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate ...

9.2/10 Wonderful! (252 reviews)

Nothing standout, everything is expected as a four star place. However I was surprised breakfast is not included. It is $15 per person which is the only hotel in my trip that doesn’t provide free breakfast.

Reviewed on Oct 31, 2025

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...

9.4/10 Exceptional! (73 reviews)

Great hotel and saff

Reviewed on Oct 20, 2025

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Minareto

Via del Faro Massolivieri 26 Syracuse SR

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy beachfront dining and relax with sun loungers and beach ...

8.8/10 Excellent! (253 reviews)

Winderfull views but the staff isn’t so supportive!

Reviewed on Nov 9, 2025

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Dimora Caiammari Luxury Hotel & Spa

Via Daniele Impellizzeri Syracuse SR

This luxury hotel features a full-service spa, 2 outdoor pools, and a restaurant. There's fun for all ages with a children's pool and a playground, and families ...

9.2/10 Wonderful! (205 reviews)

Warm, lovely

Reviewed on Oct 14, 2025

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Wellness & Spa Hotel Principe di Fitalia

Traversa Tonnara di Terrauzza 51 Syracuse SR

Fully refundableReserve now, pay when you stay

$438 nightly

$494 total

Nov 29 - Nov 30

Total with taxes and fees

An attached winery, a full-service spa, and 2 outdoor pools are all featured at this luxury hotel. There's fun for all ages with a children's club and a children's ...

9.4/10 Exceptional! (93 reviews)

This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!

Reviewed on Oct 19, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Syracuse Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.