Explore top 2026 5 Star Hotels in Syracuse

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Top Syracuse 5 Star hotels

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

5 out of 5
Viale Mazzini, 12 Syracuse SR
Fully refundableReserve now, pay when you stay
$277 nightly
The price is $317 total per night from Apr 22 to Apr 23
$317 total
Apr 22 - Apr 23
Total with taxes and fees
This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Take the beach shuttle and relax with sun loungers and beach umbrellas. WiFi in public ...
9/10 Wonderful! (587 reviews)
The hotel is beautiful and the first night I was there I was in a really cool room with a loft. I left for a week and then came back and stayed another night. This time the room was underneath the restaurant and was super loud until well after 11 PM. But overall, it’s a lovely property and very well ...

Reviewed on Apr 11, 2026

Opens in a new windowGrand Hotel Ortigia Siracusa
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

5 out of 5
Via Riva Nazario Sauro Syracuse SR
Fully refundableReserve now, pay when you stay
$393 nightly
The price is $444 total per night from Apr 23 to Apr 24
$444 total
Apr 23 - Apr 24
Total with taxes and fees
A full-service spa, 2 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (259 reviews)
The hotel itself is a beautiful building with an interesting heritage as the main post office. The location is excellent offering a great starting point for a walking tour of Ortigia. Great stay.

Reviewed on Feb 5, 2026

Opens in a new windowOrtea Palace Hotel, Sicily, Autograph Collection
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Apr 18 to Apr 19
$196 total
Apr 18 - Apr 19
Total with taxes and fees
This hotel features a restaurant, a hot tub, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate ...
Opens in a new windowCaportigia Boutique Hotel
Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

5 out of 5
Passeggio Adorno 10/12 Syracuse SR
Fully refundableReserve now, pay when you stay
$575 nightly
The price is $644 total per night from May 2 to May 3
$644 total
May 2 - May 3
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...
9.6/10 Exceptional! (75 reviews)
Beautiful hotel, room that I stayed in was small for two peopl.

Reviewed on Apr 14, 2026

Opens in a new windowGrand Hotel Des Ètrangers - The Leading Hotels of the World
Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa

5 out of 5
Via Daniele Impellizzeri Syracuse SR
$301 nightly
The price is $343 total per night from Apr 24 to Apr 25
$343 total
Apr 24 - Apr 25
Total with taxes and fees
This luxury hotel features a full-service spa, 2 outdoor pools, and a restaurant. There's fun for all ages with a children's pool and a playground, and families ...
9.4/10 Exceptional! (211 reviews)
Warm, lovely

Reviewed on Oct 14, 2025

Opens in a new windowDimora Caiammari Luxury Hotel & Spa
Minareto

Minareto

5 out of 5
Via del Faro Massolivieri 26 Syracuse SR
Fully refundableReserve now, pay when you stay
$372 nightly
The price is $421 total per night from Apr 20 to Apr 21
$421 total
Apr 20 - Apr 21
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 2 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Families ...
8.8/10 Excellent! (267 reviews)
Winderfull views but the staff isn’t so supportive!

Reviewed on Nov 9, 2025

Opens in a new windowMinareto
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Syracuse Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

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