Explore top 2026 5 Star Hotels in Eastern Sicily
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Top Eastern Sicily 5 Star hotels
Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts
Via Pirandello, 50 Taormina ME
Fully refundableReserve now, pay when you stay
$714 nightly
The price is $797 total per night from Nov 5 to Nov 6
$797 total
Nov 5 - Nov 6
Total with taxes and fees
A full-service spa, 2 restaurants, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...
9.2/10 Wonderful! (298 reviews)
"We would give this hotel 6* if it was possible. Everything from check in to check out was fantastic. The hotel and their staff are of the highest quality yet remain friendly, warm and welcoming. We came for our honeymoon and had the most wonderful time. We used the spa, ate at the restaurant, drank ..."
Reviewed on Oct 23, 2026
Romano Palace Luxury Hotel
Viale Kennedy 28 Catania CT
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $145 total per night from Nov 13 to Nov 14
$145 total
Nov 13 - Nov 14
Total with taxes and fees
This hotel features a restaurant, a seasonal outdoor pool, and a bar/lounge. Families will appreciate the onsite laundry facilities, kid-friendly dining, and ...
Grand Hotel Ortigia Siracusa
Viale Mazzini, 12 Syracuse SR
Fully refundableReserve now, pay when you stay
$244 nightly
The price is $280 total per night from Nov 16 to Nov 17
$280 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (640 reviews)
"I enjoyed four unforgettable days exploring beautiful Ortigia -staying at the Grand Hotel Ortigia, which is a 5-star luxury hotel overlooking the harbor. It is just a short stroll to the must-see landmarks such as the ruins of the Temple of Apollo, the Aretusa Fountain, and the renowned Cathedral ..."
Reviewed on Oct 26, 2026
Palazzo Sangiorgio
Via Cardinale Pappalardo, 1 Catania CT
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $290 total per night from Nov 16 to Nov 17
$290 total
Nov 16 - Nov 17
Total with taxes and fees
A full-service spa, a hot tub, and a restaurant are all featured at this luxury hotel. Business travelers can take advantage of the free WiFi in public areas. ...
9.8/10 Exceptional! (219 reviews)
"Breakfast, clean room and location! Definitely will stay at this hotel and try their hot tub next time 😀"
Reviewed on Oct 31, 2026
Mangia's Brucoli, Sicily, Autograph Collection
Contrada Gisira 1, 96010 Brucoli (SR) Italy Augusta SR
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $260 total per night from Nov 8 to Nov 9
$260 total
Nov 8 - Nov 9
Total with taxes and fees
This luxury hotel features 5 restaurants, 3 outdoor pools, and a gym. Bring the family and enjoy the free kid's club, children's pool, and playground. Relax ...
8.8/10 Excellent! (159 reviews)
"Staying will be an extremely fond memory for my wife and I. After the first night, we both decided to make our stay here our official honeymoon. The view from our room allowed for an incredible view of Mt Etna. The staff is professional and polite and very friendly. The breakfast buffet is pretty ..."
Reviewed on Oct 21, 2026
Quiete Taormina Naxos, Tapestry Collection by Hilton
Via dei Sei Mulini Giardini Naxos ME
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, ...
San Domenico Palace, Taormina, A Four Seasons Hotel
PIAZZA SAN DOMENICO, 5 Taormina ME
Fully refundableReserve now, pay when you stay
$1,505 nightly
The price is $1,667 total per night from Nov 5 to Nov 6
$1,667 total
Nov 5 - Nov 6
Total with taxes and fees
A full-service spa, 3 restaurants, and a 24-hour gym are all featured at this luxury hotel. Families will appreciate the picnic area and in-room childcare. Enjoy ...
9.4/10 Exceptional! (316 reviews)
"Best hotel ever. It is beautiful. Everything is provided, including things you never knew you needed! I literally cannot praise this hotel enough. We will be returning without a doubt."
Reviewed on Oct 26, 2026
Mazzarò Sea Palace - The Leading Hotels of the World
Via Nazionale 147 Taormina ME
Fully refundableReserve now, pay when you stay
$646 nightly
The price is $721 total per night from Nov 13 to Nov 14
$721 total
Nov 13 - Nov 14
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
NH Collection Taormina
Via Circonvallazione 11 Taormina ME
Fully refundableReserve now, pay when you stay
$314 nightly
The price is $357 total per night from Nov 16 to Nov 17
$357 total
Nov 16 - Nov 17
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (618 reviews)
"Clean room"
Reviewed on Oct 30, 2026
Ortea Palace Hotel, Sicily, Autograph Collection
Via Riva Nazario Sauro Syracuse SR
Fully refundableReserve now, pay when you stay
$252 nightly
The price is $288 total per night from Nov 29 to Nov 30
$288 total
Nov 29 - Nov 30
Total with taxes and fees
A full-service spa, 2 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (286 reviews)
"Everyone was incredibly helpful and the restaurant staff were wonderful and food was delicious ! The Hotel was beautiful and we would definitely return. TY"
Reviewed on Oct 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Eastern Sicily Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Eastern Sicily to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Eastern Sicily 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Eastern Sicily before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Eastern Sicily hotel reviews by fellow wanderers
Palace Catania | UNA Esperienze
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Nice hotel, clean and convenient location."
A verified traveler stayed at Palace Catania | UNA Esperienze
