Explore top 2026 4 Star Hotels in Mesopotamia

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Top Mesopotamia 4 Star hotels

Holiday Inn Rosario by IHG

Holiday Inn Rosario by IHG

4 out of 5
Dorrego 450 Rosario Santa Fe
Fully refundable
The price is $111 total per night from Nov 8 to Nov 9
$111 total
per night
Nov 8 - Nov 9
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9.4/10 Exceptional! (395 reviews)
"Lo que más nos gustó del hotel fué la localización, cerca de la casa de nuestros familiares, en una parte céntrica de la ciudad y en una zona cercana a restaurantes y tiendas. el servicio de wifi del hotel no tuvo ninguna falla, pudimos trabajar sin interrupciones a cualquier hora del día. Normalmente, ..."

Reviewed on Oct 23, 2026

Opens in a new windowHoliday Inn Rosario by IHG
InterTower Hotel

InterTower Hotel

4 out of 5
San Jeronimo 2779 Santa Fe Santa Fe
Fully refundableReserve now, pay when you stay
The price is $121 total per night from Dec 5 to Dec 6
$121 total
per night
Dec 5 - Dec 6
A full-service spa, an outdoor pool, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (236 reviews)
"The property was nice and in the middle of town where there is a lot action going on. It was convenient to all the historic sites we wanted to see via walking, cab or uber. Breakfast was very nice. The staff was very accommodating of any requests we made. The property is a bit older but it is well ..."

Reviewed on Nov 4, 2026

Opens in a new windowInterTower Hotel
Dazzler by Wyndham Rosario

Dazzler by Wyndham Rosario

4 out of 5
Junin 187 Rosario Santa Fe
Fully refundableReserve now, pay when you stay
The price is $91 total per night from Nov 15 to Nov 16
$91 total
per night
Nov 15 - Nov 16
This hotel features an outdoor pool, a hot tub, and a restaurant. Enjoy the gym and free perks like buffet breakfast and WiFi in public areas. There's a bar/lounge ...
8.8/10 Excellent! (223 reviews)
"Highly recommend and love to stay again"

Reviewed on Oct 28, 2026

Opens in a new windowDazzler by Wyndham Rosario
Howard Johnson Plaza La Ribera

Howard Johnson Plaza La Ribera

4.5 out of 5
Av del BICENTENARIO 20 Resistencia Chaco
Fully refundableReserve now, pay when you stay
The price is $76 total per night from Nov 10 to Nov 11
$76 total
per night
Nov 10 - Nov 11
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, ...
9.2/10 Wonderful! (174 reviews)
"Beautiful hotel. Staff could be more helpful."

Reviewed on May 18, 2026

Opens in a new windowHoward Johnson Plaza La Ribera
Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is $152 total per night from Nov 29 to Nov 30
$152 total
per night
Nov 29 - Nov 30
This hotel features a gym and a steam room. WiFi in public areas is free.
9.8/10 Exceptional! (54 reviews)
"👍"

Reviewed on Nov 3, 2026

Opens in a new windowMarriott Corrientes Hotel
Amérian Hotel Casino Gala

Amérian Hotel Casino Gala

4 out of 5
Juan Domingo Perón 330 esq. Necochea Resistencia Chaco
Fully refundableReserve now, pay when you stay
The price is $68 total per night from Nov 20 to Nov 21
$68 total
per night
Nov 20 - Nov 21
A casino and an outdoor pool are featured at this smoke-free hotel. Enjoy a meal from the restaurant and perks like free buffet breakfast and free WiFi. Luggage ...
9/10 Wonderful! (207 reviews)
"Wanderfull like always tanks you"

Reviewed on Oct 26, 2026

Opens in a new windowAmérian Hotel Casino Gala
Esplendor by Wyndham Savoy Rosario

Esplendor by Wyndham Savoy Rosario

4 out of 5
San Lorenzo 1022 Rosario Santa Fe
Fully refundableReserve now, pay when you stay
The price is $95 total per night from Nov 8 to Nov 9
$95 total
per night
Nov 8 - Nov 9
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the seasonal ...
Opens in a new windowEsplendor by Wyndham Savoy Rosario
Brickton, Rosario, Apartments By Marriott Bonvoy

Brickton, Rosario, Apartments By Marriott Bonvoy

4 out of 5
Montevideo 14 Rosario Sante Fe
Fully refundableReserve now, pay when you stay
The price is $80 total per night from Nov 8 to Nov 9
$80 total
per night
Nov 8 - Nov 9
A gym, self parking, and laundry facilities are featured at this aparthotel. WiFi in public areas is free. Luggage storage is provided and the front desk is ...
Opens in a new windowBrickton, Rosario, Apartments By Marriott Bonvoy
Radisson RED Funes

Radisson RED Funes

4.5 out of 5
colectora 2 de abril 3501 (autopista Rosario Córdoba km 307.5) Funes SF
Fully refundable
The price is $128 total per night from Nov 29 to Nov 30
$128 total
per night
Nov 29 - Nov 30
A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 5 conference rooms, free WiFi ...
9.4/10 Exceptional! (8 reviews)
"Excelente estadía. Lo repetiremos"

Reviewed on Aug 30, 2026

Opens in a new windowRadisson RED Funes
Pullman Rosario City Center Hotel

Pullman Rosario City Center Hotel

4 out of 5
Av Batlle Y Ordoñez Y Bv Oroño Rosario Santa Fe
Fully refundableReserve now, pay when you stay
The price is $105 total per night from Dec 4 to Dec 5
$105 total
per night
Dec 4 - Dec 5
This Beaux Arts hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a playground and an arcade/game room, and families ...
8.6/10 Excellent! (281 reviews)
"I arrived around 11 AM and was told the room wasn’t available. Because I was extremely tired after + 12 hours of flying, I insisted and was offered the room for an additional ~$75. It was the same room, not an upgrade, which made it feel like the room was already ready and that it was more about ..."

Reviewed on Jan 29, 2026

Opens in a new windowPullman Rosario City Center Hotel
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4 Star Hotels Mesopotamia

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Mesopotamia 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Mesopotamia will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Mesopotamia, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Mesopotamia hotel reviews by fellow wanderers