American Airlines Flight 543 Deals & Information (2026/2027)

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American Airlines Flight 543 Route Deals From $270

The cheapest prices found with in the last 7 days for return flights were $164 and $270 for one-way flights to John Wayne for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Feb 21 - Tue, Feb 24
PHX
Sky Harbor Intl.
SNA
John Wayne
$164 Roundtrip, found 12 hours ago
$164
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Sat, Feb 21 from Sky Harbor Intl. to John Wayne, returning Tue, Feb 24, priced at $164 found 12 hours ago

Frequently asked questions

What route does flight number AA543 take?
AA543 is used on multiple routes, but the most common is between Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.) and Miami Intl. Airport (MIA). If you manage to score a direct flight, you'll disembark the plane in roughly 2 hours and 9 minutes. Multi-stop flights can also operate under the same number, as can flights on other routes.
What kind of plane is on flight number AA543?
There's every chance you'll be heading off on the Boeing 777-200 if you've booked a ticket from Charlotte-Douglas Intl. Airport (CLT) to MIA, one of several routes used for flight number AA543.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA543 flight with Travelocity, please visit our Customer Service Portal.