American Airlines Flight AA5381 Deals & Information (2025/2026)

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American Airlines Flight 5381 Route Deals From $257

The cheapest prices found with in the last 7 days for return flights were $704 and $257 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Sep 7 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$704 Roundtrip, found 1 day ago
$704
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Sep 7 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $704 found 1 day ago
Tue, Sep 9 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$720 Roundtrip, found 1 day ago
$720
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 9 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $720 found 1 day ago
Sun, Sep 7 - Thu, Sep 11
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$823 Roundtrip, found 1 day ago
$823
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Sep 7 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Thu, Sep 11, priced at $823 found 1 day ago
Mon, Sep 8 - Thu, Sep 11
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$854 Roundtrip, found 1 day ago
$854
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Sep 8 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Thu, Sep 11, priced at $854 found 1 day ago

Frequently asked questions

What route does flight number AA5381 take?
AA5381 is used on a range of routes. Most commonly, AA5381 flies direct from GSP to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If that's your flight path, you'll be in the air for around 1 hour and 16 minutes.
What kind of plane is on flight number AA5381?
AA5381 is a flight number that's used on many routes. If you're booked on the most popular one, Greenville-Spartanburg Intl. Airport (GSP) to Charlotte Airport, there's a good chance you'll be climbing on board a Bombardier CRJ900.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5381 flight with Travelocity, please visit our Customer Service Portal.