American Airlines Flight AA5381 Deals & Information (2025/2026)

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American Airlines Flight 5381 Route Deals From $239

The cheapest prices found with in the last 7 days for return flights were $503 and $239 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jun 17 - Thu, Jun 26
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$503 Roundtrip, found 6 days ago
$503
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jun 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Thu, Jun 26, priced at $503 found 6 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$503 Roundtrip, found 2 days ago
$503
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $503 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$513 Roundtrip, found 2 days ago
$513
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $513 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$523 Roundtrip, found 2 days ago
$523
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $523 found 2 days ago
Thu, Jun 19 - Thu, Jun 26
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$532 Roundtrip, found 6 days ago
$532
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jun 19 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Thu, Jun 26, priced at $532 found 6 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$535 Roundtrip, found 2 days ago
$535
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $535 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$557 Roundtrip, found 2 days ago
$557
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $557 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$566 Roundtrip, found 2 days ago
$566
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $566 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$606 Roundtrip, found 2 days ago
$606
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $606 found 2 days ago
Wed, Jun 18 - Mon, Jun 23
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$616 Roundtrip, found 2 days ago
$616
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Jun 23, priced at $616 found 2 days ago

Frequently asked questions

What route does flight number AA5381 take?
AA5381 is used on a range of routes. Most commonly, AA5381 flies direct from GSP to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If that’s your flight path, you’ll be in the air for around 1 hour and 16 minutes.
What kind of plane is on flight number AA5381?
AA5381 is a flight number that’s used on many routes. If you’re booked on the most popular one, Greenville-Spartanburg Intl. Airport (GSP) to Charlotte Airport, there’s a good chance you’ll be climbing on board a Bombardier CRJ900.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5381 flight with Travelocity, please visit our Customer Service Portal.