American Airlines Flight 5381 Deals & Information (2025/2026)

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American Airlines Flight 5381 Route Deals From $160

The cheapest prices found with in the last 7 days for return flights were $355 and $160 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$355 Roundtrip, found 5 days ago
$355
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $355 found 5 days ago
Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$361 Roundtrip, found 5 days ago
$361
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $361 found 5 days ago
Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$380 Roundtrip, found 5 days ago
$380
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $380 found 5 days ago
Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$406 Roundtrip, found 5 days ago
$406
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $406 found 5 days ago
Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$420 Roundtrip, found 5 days ago
$420
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $420 found 5 days ago
Wed, Sep 10 - Fri, Sep 12
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$425 Roundtrip, found 5 days ago
$425
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 10 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 12, priced at $425 found 5 days ago
Tue, Sep 9 - Sat, Sep 20
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$451 Roundtrip, found 5 days ago
$451
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 9 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Sat, Sep 20, priced at $451 found 5 days ago
Fri, Sep 12 - Fri, Sep 19
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$453 Roundtrip, found 5 days ago
$453
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 12 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 19, priced at $453 found 5 days ago
Tue, Sep 9 - Fri, Sep 19
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$457 Roundtrip, found 5 days ago
$457
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 9 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Fri, Sep 19, priced at $457 found 5 days ago
Fri, Sep 12 - Mon, Sep 15
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$457 Roundtrip, found 5 days ago
$457
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Sep 12 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Mon, Sep 15, priced at $457 found 5 days ago

Frequently asked questions

What route does flight number AA5381 take?
AA5381 is used on a range of routes. Most commonly, AA5381 flies direct from GSP to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If that's your flight path, you'll be in the air for around 1 hour and 16 minutes.
What kind of plane is on flight number AA5381?
AA5381 is a flight number that's used on many routes. If you're booked on the most popular one, Greenville-Spartanburg Intl. Airport (GSP) to Charlotte Airport, there's a good chance you'll be climbing on board a Bombardier CRJ900.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5381 flight with Travelocity, please visit our Customer Service Portal.