American Airlines Flight 5221 Deals & Information (2026/2027)

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American Airlines Flight 5221 Route Deals From $137

The cheapest prices found with in the last 7 days for return flights were $223 and $137 for one-way flights to Detroit Metropolitan Wayne County for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jun 23 - Thu, Jul 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$223 Roundtrip, found 10 hours ago
$223
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Jul 2, priced at $223 found 10 hours ago
Tue, Jun 23 - Thu, Jul 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$233 Roundtrip, found 10 hours ago
$233
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Jul 2, priced at $233 found 10 hours ago
Fri, Jun 5 - Wed, Jun 10
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$259 Roundtrip, found 23 hours ago
$259
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jun 5 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Jun 10, priced at $259 found 23 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you've booked a seat on this route, you'll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you're traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it's a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline's top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you'll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.