American Airlines Flight 5221 Deals & Information (2026/2027)

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American Airlines Flight 5221 Route Deals From $181

The cheapest prices found with in the last 7 days for return flights were $237 and $181 for one-way flights to Detroit Metropolitan Wayne County for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, May 20 - Mon, May 25
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$237 Roundtrip, found 4 days ago
$237
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, May 20 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Mon, May 25, priced at $237 found 4 days ago
Sat, May 2 - Mon, May 4
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$242 Roundtrip, found 2 days ago
$242
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, May 2 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Mon, May 4, priced at $242 found 2 days ago
Fri, Jun 5 - Wed, Jun 10
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jun 5 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Jun 10, priced at $267 found 1 day ago
Tue, Apr 28 - Thu, Apr 30
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$271 Roundtrip, found 1 day ago
$271
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Apr 28 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Apr 30, priced at $271 found 1 day ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you've booked a seat on this route, you'll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you're traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it's a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline's top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you'll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.