American Airlines Flight 5221 Deals & Information (2026/2027)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 5221 Route Deals From $176

The cheapest prices found with in the last 7 days for return flights were $199 and $176 for one-way flights to Detroit Metropolitan Wayne County for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$199 Roundtrip, found 4 hours ago
$199
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $199 found 4 hours ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$243 Roundtrip, found 6 days ago
$243
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $243 found 6 days ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$247 Roundtrip, found 6 days ago
$247
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $247 found 6 days ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $251 found 6 days ago
Mon, Jun 29 - Tue, Jul 7
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$259 Roundtrip, found 2 hours ago
$259
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Mon, Jun 29 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jul 7, priced at $259 found 2 hours ago
Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$264 Roundtrip, found 4 hours ago
$264
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $264 found 4 hours ago
Thu, May 14 - Mon, May 18
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$265 Roundtrip, found 2 hours ago
$265
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, May 14 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Mon, May 18, priced at $265 found 2 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you've booked a seat on this route, you'll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you're traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it's a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline's top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you'll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.