American Airlines Flight 5221 Deals & Information (2026/2027)

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American Airlines Flight 5221 Route Deals From $175

The cheapest prices found with in the last 7 days for return flights were $199 and $175 for one-way flights to Detroit Metropolitan Wayne County for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $199 found 1 day ago
Wed, May 13 - Mon, May 18
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$254 Roundtrip, found 10 hours ago
$254
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, May 13 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Mon, May 18, priced at $254 found 10 hours ago
Thu, Jun 4 - Thu, Jun 11
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$255 Roundtrip, found 12 hours ago
$255
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Thu, Jun 4 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Jun 11, priced at $255 found 12 hours ago
Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $264 found 1 day ago
Tue, Jun 9 - Tue, Jun 16
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$270 Roundtrip, found 7 hours ago
$270
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Jun 9 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 16, priced at $270 found 7 hours ago
Fri, May 15 - Sun, May 17
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$280 Roundtrip, found 3 hours ago
$280
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 15 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sun, May 17, priced at $280 found 3 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you've booked a seat on this route, you'll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you're traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it's a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline's top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you'll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.