American Airlines Flight 5221 Deals & Information (2026/2027)

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American Airlines Flight 5221 Route Deals From

The cheapest prices found with in the last 7 days for return flights were $197 and for one-way flights to Detroit Metropolitan Wayne County for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $197 found 2 days ago
Wed, May 13 - Sun, May 17
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$228 Roundtrip, found 11 hours ago
$228
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Wed, May 13 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sun, May 17, priced at $228 found 11 hours ago
Wed, Jun 17 - Wed, Jun 24
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$232 Roundtrip, found 2 days ago
$232
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 17 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Jun 24, priced at $232 found 2 days ago
Wed, Aug 19 - Wed, Aug 26
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$233 Roundtrip, found 2 days ago
$233
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 19 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Aug 26, priced at $233 found 2 days ago
Mon, May 18 - Sat, May 23
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$235 Roundtrip, found 2 days ago
$235
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, May 18 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sat, May 23, priced at $235 found 2 days ago
Wed, May 13 - Sun, May 17
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$238 Roundtrip, found 11 hours ago
$238
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Wed, May 13 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sun, May 17, priced at $238 found 11 hours ago
Wed, Jun 17 - Wed, Jun 24
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$242 Roundtrip, found 2 days ago
$242
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 17 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Wed, Jun 24, priced at $242 found 2 days ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$243 Roundtrip, found 1 day ago
$243
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $243 found 1 day ago
Thu, Jun 4 - Thu, Jun 11
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$247 Roundtrip, found 16 hours ago
$247
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Jun 4 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Jun 11, priced at $247 found 16 hours ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $247 found 1 day ago
Sat, May 30 - Tue, Jun 2
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$251 Roundtrip, found 1 day ago
$251
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 30 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Tue, Jun 2, priced at $251 found 1 day ago
Wed, Jul 1 - Sat, Jul 4
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 1 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sat, Jul 4, priced at $258 found 1 day ago
Wed, Jul 1 - Sat, Jul 4
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 1 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Sat, Jul 4, priced at $259 found 1 day ago
Thu, Jun 4 - Thu, Jun 11
DCA
Ronald Reagan Washington National
DTW
Detroit Metropolitan Wayne County
$262 Roundtrip, found 16 hours ago
$262
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Jun 4 from Ronald Reagan Washington National to Detroit Metropolitan Wayne County, returning Thu, Jun 11, priced at $262 found 16 hours ago

Frequently asked questions

What route does flight number AA5221 take?
AA5221 is used on multiple routes. More commonly, AA5221 flies straight from Daytona Beach, FL Airport (DAB-Daytona Beach Intl.) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If you've booked a seat on this route, you'll be up above the clouds for around 1 hour and 48 minutes.
How often is AA5221 on time?
If you're traveling with American Airlines flight number AA5221 from DAB to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), it's a relief knowing that their planes run according to schedule 92% of the time. In the rare event that a flight is running behind schedule, it should only be delayed by around 10 minutes. Thanks to this airline's top standards, this flight has a 3.9-star rating.
What kind of plane is on flight number AA5221?
If you have a seat on flight AA5221 from Daytona Beach Intl. Airport (DAB) to Charlotte Airport, you'll likely be aboard the Bombardier CRJ900. This flight number serves a number of routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5221 flight with Travelocity, please visit our Customer Service Portal.