American Airlines Flight 4648 Deals & Information (2026/2027)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 4648 Route Deals From $79

The cheapest prices found with in the last 7 days for return flights were $157 and $79 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jun 1 - Wed, Jun 3
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$157 Roundtrip, found 14 hours ago
$157
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Mon, Jun 1 from LaGuardia to Buffalo Niagara Intl., returning Wed, Jun 3, priced at $157 found 14 hours ago
Tue, Jun 9 - Fri, Jun 12
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$181 Roundtrip, found 1 day ago
$181
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jun 9 from LaGuardia to Buffalo Niagara Intl., returning Fri, Jun 12, priced at $181 found 1 day ago
Tue, May 19 - Thu, May 21
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$192 Roundtrip, found 9 hours ago
$192
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, May 19 from LaGuardia to Buffalo Niagara Intl., returning Thu, May 21, priced at $192 found 9 hours ago
Mon, May 11 - Wed, May 13
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$204 Roundtrip, found 2 days ago
$204
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, May 11 from LaGuardia to Buffalo Niagara Intl., returning Wed, May 13, priced at $204 found 2 days ago
Mon, Jun 1 - Wed, Jun 3
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$207 Roundtrip, found 14 hours ago
$207
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Mon, Jun 1 from LaGuardia to Buffalo Niagara Intl., returning Wed, Jun 3, priced at $207 found 14 hours ago
Mon, May 25 - Tue, May 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$212 Roundtrip, found 1 hour ago
$212
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, May 25 from LaGuardia to Buffalo Niagara Intl., returning Tue, May 26, priced at $212 found 1 hour ago
Mon, May 25 - Tue, May 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$212 Roundtrip, found 1 hour ago
$212
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, May 25 from LaGuardia to Buffalo Niagara Intl., returning Tue, May 26, priced at $212 found 1 hour ago
Wed, Aug 5 - Sat, Aug 8
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$214 Roundtrip, found 6 days ago
$214
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Aug 5 from LaGuardia to Buffalo Niagara Intl., returning Sat, Aug 8, priced at $214 found 6 days ago
Wed, Aug 12 - Sun, Aug 16
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$227 Roundtrip, found 13 hours ago
$227
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Aug 12 from LaGuardia to Buffalo Niagara Intl., returning Sun, Aug 16, priced at $227 found 13 hours ago
Sun, Aug 16 - Wed, Aug 19
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$229 Roundtrip, found 2 days ago
$229
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Aug 16 from LaGuardia to Buffalo Niagara Intl., returning Wed, Aug 19, priced at $229 found 2 days ago

Frequently asked questions

What route does flight number AA4648 take?
AA4648 serves multiple routes, but the most common is between Charleston Intl. Airport (CHS) and Ronald Reagan Washington National Airport (DCA). If your flight is direct, you'll land in 1 hour and 37 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4648?
If you've booked a ticket on flight AA4648 from CHS to National Airport, there's every chance you'll be aboard an Embraer 175. Flight AA4648 serves several routes, but this is the busiest.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4648 flight with Travelocity, please visit our Customer Service Portal.