American Airlines Flight 2421 Deals & Information (2026/2027)

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American Airlines Flight 2421 Route Deals From $178

The cheapest prices found with in the last 7 days for return flights were $357 and $178 for one-way flights to Des Moines Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 17 - Tue, Sep 22
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$357 Roundtrip, found 2 hours ago
$357
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Tue, Sep 22, priced at $357 found 2 hours ago
Tue, Aug 11 - Wed, Aug 19
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$366 Roundtrip, found 9 hours ago
$366
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, Aug 19, priced at $366 found 9 hours ago
Tue, Aug 11 - Wed, Aug 19
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$373 Roundtrip, found 9 hours ago
$373
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, Aug 19, priced at $373 found 9 hours ago
Tue, Aug 11 - Wed, Aug 19
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$379 Roundtrip, found 9 hours ago
$379
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, Aug 19, priced at $379 found 9 hours ago
Thu, Sep 17 - Tue, Sep 22
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$387 Roundtrip, found 2 hours ago
$387
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Tue, Sep 22, priced at $387 found 2 hours ago
Thu, Sep 17 - Tue, Sep 22
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$389 Roundtrip, found 2 hours ago
$389
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Tue, Sep 22, priced at $389 found 2 hours ago
Thu, Sep 17 - Tue, Sep 22
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$390 Roundtrip, found 2 hours ago
$390
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Tue, Sep 22, priced at $390 found 2 hours ago
Wed, Nov 18 - Wed, Nov 25
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$391 Roundtrip, found 10 hours ago
$391
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Nov 18 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, Nov 25, priced at $391 found 10 hours ago
Wed, Nov 18 - Wed, Nov 25
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$393 Roundtrip, found 10 hours ago
$393
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Nov 18 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, Nov 25, priced at $393 found 10 hours ago

Frequently asked questions

What route does flight number AA2421 take?
You'll be touching down at San Francisco Airport from Miami Intl. Airport (MIA) if you've booked a ticket on flight number AA2421. You'll be in the air for 6 hours and 2 minutes during this journey. What's more, the flight conveniently travels non-stop.
How often is AA2421 on time?
Around 50% of flight number AA2421 planes take off on time — so you may want to leave some room in your itinerary. If you experience a delay, the average wait is about 24 minutes. Be aware of this if you need to make a connecting journey or your friends are picking you up from the airport. This trip has a star rating of 1.55.
What kind of plane is on flight number AA2421?
The Airbus A321 is the aircraft that's generally used for flight AA2421. Typically, this flight takes off from MIA and touches down at San Francisco, CA Airport (SFO-San Francisco Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA2421 flight with Travelocity, please visit our Customer Service Portal.