Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$111 nightly
The price is $128 total per night from Mar 8 to Mar 9
$128 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Cold room, heater wouldn’t stay on when on very noisy large window with a see through blind, staff both at check in and out were not polite
Reviewed on Mar 7, 2026

Aspen Suites
1211 2nd Street Rochester MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Mar 8 to Mar 9
$175 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
We appreciate how they go out of their way to cater to families with patients in the hospital. After sitting in the surgical waiting room all day, it was such a wonderful surprise to be offered a bowl of hot soup to take up to our room for the night. We certainly did not feel like eating out ...
Reviewed on Mar 7, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Mar 14 to Mar 15
$160 total
Mar 14 - Mar 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Staff, location, clean & soup in the evenings.
Reviewed on Feb 25, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$90 nightly
The price is $104 total per night from Apr 3 to Apr 4
$104 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Overall it was an ok stay. Very small room. Bathroom didn’t have a working vent. Common area microwave barely functioned.
Reviewed on Mar 5, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Mar 20 to Mar 21
$108 total
Mar 20 - Mar 21
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
The rooms were so nice and clean. The staff was very nice. The pool was warm. I wish the pool area was nicer, but overall it was good.
Reviewed on Feb 22, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Mar 9 to Mar 10
$146 total
Mar 9 - Mar 10
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Love staying here during appointments at Mayo Clinic. Our home away from home, warm, welcoming and cozy. Best access to the clinic during the winter months is through the subway system. Both restaurants on site are excellent. Highly recommend the valet service.
Reviewed on Mar 7, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Mar 15 to Mar 16
$91 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
clean rooms and hotel in total was clean.
Reviewed on Mar 6, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $88 total per night from Mar 20 to Mar 21
$88 total
Mar 20 - Mar 21
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Very pleased to be informed about shuttle to the Mayo..
Reviewed on Mar 7, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Mar 8 to Mar 9
$152 total
Mar 8 - Mar 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Clean and quiet
Reviewed on Mar 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Wykoff hotel reviews by fellow wanderers

Kahler Grand Hotel
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Love staying here during appointments at Mayo Clinic. Our home away from home, warm, welcoming and cozy. Best access to the clinic during the winter months is through the subway system. Both restaurants on site are excellent. Highly recommend the valet service. "
A verified traveler stayed at Kahler Grand Hotel
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