Book Hotels in Wykoff, MN
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Top Wykoff hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Fully refundable
$117 nightly
The price is $134 total per night from May 22 to May 23
$134 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean room, nice breakfast, good gym, excellent location
Reviewed on Apr 30, 2026

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from May 10 to May 11
$160 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
Very convenient to the clinic
Reviewed on May 4, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Fully refundable
$93 nightly
The price is $107 total per night from May 23 to May 24
$107 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Good stay
Reviewed on Apr 22, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from May 8 to May 9
$131 total
May 8 - May 9
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
great bar and restaurant!
Reviewed on May 4, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
1125 2nd St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from May 16 to May 17
$108 total
May 16 - May 17
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Room was fine and clean. Morning and afternoon front desk were a delight! Parking is awful there, I get it’s limited but they had a sold out hotel. We were told we could park in an additional lot, but then was told we could not. We were informed we would not have to pay for parking-but would have ...
Reviewed on May 4, 2026

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 10 to May 11
$146 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Overall just a nightmare to deal with. Lots of saying one thing and then not being able to follow through.
Reviewed on May 4, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from May 24 to May 25
$86 total
May 24 - May 25
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Friendly and helpful staff. Very good breakfast. Comfortable beds and clean rooms.
Reviewed on May 4, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from May 10 to May 11
$108 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
The breakfast was cold, what was left of it anyways. Bath tub wouldn’t drain as we took a shower. No hot water. We were given 3 towels and were told they didn’t have more when we asked. Air in room barely worked.
Reviewed on May 3, 2026

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 5 to May 6
$152 total
May 5 - May 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Bed was horrible. Couch and chair need replaced. All the furniture was old and worn out. The beds were so uncomfortable. You could feel the springs and whenever you moved the bed made noise
Reviewed on May 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Wykoff hotel reviews by fellow wanderers

AmericInn by Wyndham Rochester Near Mayo Clinic
5 out of 5
Posted 6 hours ago
Travelocity Verified Review
"Friendly and helpful staff. Very good breakfast. Comfortable beds and clean rooms."
A verified traveler stayed at AmericInn by Wyndham Rochester Near Mayo Clinic
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