Find a Hotel in Medical Center District

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Top hotels in Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $142 total per night from Feb 8 to Feb 9
$142 total
Feb 8 - Feb 9
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
We enjoyed the complimentary services and convenient location.

Reviewed on Jan 23, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $169 total per night from Feb 1 to Feb 2
$169 total
Feb 1 - Feb 2
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Very nice staff, very clean room, great location near riverwalk, shops and restaurants. We liked that you have to have your room key to go on the elevator - it felt safer! Our city view was nice, but we did have to move a night stand table to be able to open the window cover, and look out. I brought ...

Reviewed on Jan 25, 2026

Opens in a new windowHotel Valencia Riverwalk
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $128 total per night from Feb 5 to Feb 6
$128 total
Feb 5 - Feb 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Historical hospitality! Great hotel!

Reviewed on Jan 22, 2026

Opens in a new windowMenger Hotel
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
Fully refundable
$115 nightly
The price is $136 total per night from Feb 22 to Feb 23
$136 total
Feb 22 - Feb 23
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this smoke-free hotel. There's fun for all ages with a lazy river and mini golf, and families ...
Would have given 5 stars, but the water flow was weak and the food availability was limited. But it’s not too far from a Walmart. We did the tour and the rooms on showcase are so much nicer.

Reviewed on Jan 25, 2026

Opens in a new windowHyatt Vacation Club at Wild Oak Ranch, San Antonio
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $120 total per night from Jan 30 to Jan 31
$120 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the laundry service and WiFi in public areas. Enjoy ...
Very pretty inside The hotel rooms give off very modern. Rooms well kept and clean. Will be rebooking when I’m back in the city!

Reviewed on Jan 22, 2026

Opens in a new windowSan Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Jan 29 to Jan 30
$105 total
Jan 29 - Jan 30
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference center. ...
Great stay with nice breakfast and clean rooms

Reviewed on Jan 23, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $127 total per night from Jan 29 to Jan 30
$127 total
Jan 29 - Jan 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
It was nice

Reviewed on Jan 25, 2026

Opens in a new windowRiverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $104 total per night from Feb 8 to Feb 9
$104 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
very nice and clean rooms close to all the good attractions

Reviewed on Jan 23, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $78 total per night from Jan 30 to Jan 31
$78 total
Jan 30 - Jan 31
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. A fireplace in the lobby is also ...
Clean room and easy check in

Reviewed on Jan 15, 2026

Opens in a new windowPark Inn by Radisson
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

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