Explore top 2026 4 Star Hotels in St. Ann
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Top St. Ann 4 Star hotels
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $169 total per night from May 31 to Jun 1
$169 total
May 31 - Jun 1
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,056 reviews)
"Clean and very helpful staff"
Reviewed on May 28, 2026
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Jun 11 to Jun 12
$158 total
Jun 11 - Jun 12
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,081 reviews)
"Beautiful property and rooms. Very nice lobby with restaurant and bar. Onsite parking, but costs to park. Wonderful staff!"
Reviewed on May 25, 2026
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $183 total per night from Jun 7 to Jun 8
$183 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,862 reviews)
"Cool space. It’s in downtown and pretty deserted at night. The staff was helpful when we had to change rooms because of an HVAC issue, however the beds were hard as a rock."
Reviewed on May 28, 2026
Live by Loews - St.Louis
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Jun 21 to Jun 22
$189 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,190 reviews)
"Always a great stay. Great staff. Clean rooms. Walking distance from food and entertainment. Great!"
Reviewed on May 27, 2026
River City Casino & Hotel
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $114 total per night from Jun 7 to Jun 8
$114 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,577 reviews)
"Staff was very friendly when they checked in the room was very nice. The casino is very clean for restaurants were nice. We ate at the steakhouse and the beer house while we were there. Both were excellent recommend staying."
Reviewed on May 28, 2026
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $155 total per night from Jun 28 to Jun 29
$155 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,279 reviews)
"Room was nice and clean, and I felt very safe as a solo female traveler. Location is excellent."
Reviewed on May 27, 2026
The Royal Sonesta Chase Park Plaza St. Louis
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$200 nightly
The price is $236 total per night from Jun 7 to Jun 8
$236 total
Jun 7 - Jun 8
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,000 reviews)
"What a great place! Would stay here hands down next time we visit!!"
Reviewed on May 24, 2026
Hilton St. Louis Frontenac
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $161 total per night from Jun 21 to Jun 22
$161 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (1,000 reviews)
"Great room service. The restaurant was quite good."
Reviewed on May 25, 2026
St. Louis Union Station Hotel, Curio Collection by Hilton
1820 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $175 total per night from Jun 12 to Jun 13
$175 total
Jun 12 - Jun 13
Total with taxes and fees
This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $247 total per night from May 31 to Jun 1
$247 total
May 31 - Jun 1
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...
8.6/10 Excellent! (1,001 reviews)
"I would have like to know that the indoor pool closes at 6pm. The pool was part of the reason stayed. When called previously the staff told us later hours."
Reviewed on May 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
4 Star Hotels St. Ann
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in St. Ann 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in St. Ann will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in St. Ann, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent St. Ann hotel reviews by fellow wanderers
Pear Tree Inn St. Louis Airport
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"This place was a surprise, I needed a place for one night due to my last minute flight change. They had a shuttle which runs every 20 min which was so convenient. Rooms were very clean and breakfast was very good. Friendly staff and shuttle drivers made the entire stay pleasant"
A verified traveler stayed at Pear Tree Inn St. Louis Airport
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