Hotels with Air Conditioning in Southeast Missouri from $56

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Southeast Missouri Hotels with Air Conditioning

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

2.5 out of 5
4245 Hunt Rd Farmington MO
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $113 total per night
$113 total
Nov 23 - Nov 24
Total with taxes and fees
A golf course and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$59 nightly
The price is $68 total per night
$68 total
Dec 16 - Dec 17
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $96 total per night
$96 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Free Cancellation
$77 nightly
The price is $92 total per night
$92 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
Free Cancellation
Reserve now, pay when you stay
$82 nightly
The price is $89 total per night
$89 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Free Cancellation
Reserve now, pay when you stay
$82 nightly
The price is $93 total per night
$93 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $72 total per night
$72 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street, Perryville, MO
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $78 total per night
$78 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $78 total per night
$78 total
Nov 27 - Nov 28
Total with taxes and fees
This hotel features an outdoor pool and a gym. Enjoy the hot tub and free perks like daily breakfast and free self parking. The front desk is staffed around-the-clock ...
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
Get rates
This motel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
OYO Hickory House Inn

OYO Hickory House Inn

2.5 out of 5
1802 N Outer Rd, Dexter, MO
Free Cancellation
Reserve now, pay when you stay
$57 nightly
The price is $63 total per night
$63 total
Dec 17 - Dec 18
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...
Econo Lodge

Econo Lodge

2 out of 5
110 Independence Ave Kennett MO
Free Cancellation
Reserve now, pay when you stay
$49 nightly
The price is $56 total per night
$56 total
Dec 18 - Dec 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri hotels essential information

Accommodation
610 hotels
Lowest Price
$56
Highest Price
$113
Popular hotels
OYO Hickory House Inn, Days Inn and Suites by Wyndham Sikeston, Super 8 by Wyndham Pevely, Best Western Plus Sikeston, Candlewood Suites Cape Girardeau by IHG, Comfort Inn Festus - St Louis South, Quality Inn Perryville I-55, Comfort Suites Jackson-Cape Girardeau, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Crown Pointe Lodge, BW Signature Collection, Econo Lodge, Days Inn by Wyndham Perryville

Recent Southeast Missouri hotel reviews by fellow wanderers

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

5 out of 5
Posted 5 days ago
Travelocity Verified Review
"good"
A verified traveler stayed at Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center

Explore More Ways to Travel with Travelocity