Book Kid-Friendly Hotels in Southeast Missouri from $65

Name: Comfort Suites Jackson-Cape Girardeau
Price range: $96 total
Rating: 8.2

Find & compare hotels, resorts and vacation rentals for the whole family

Top Southeast Missouri Kid Friendly Hotels

Drury Inn & Suites Jackson MO

225 Drury Lane Jackson MO

Fully refundableReserve now, pay when you stay

$80 nightly

$85 total

Mar 16 - Mar 17

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.6/10 Exceptional! (1,009 reviews)

This was our first stay at a Drury hotel

Reviewed on Mar 5, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Mar 17 - Mar 18

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...

9.4/10 Exceptional! (1,001 reviews)

Great 👍

Reviewed on Mar 11, 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Mar 18 - Mar 19

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,009 reviews)

Easy parking. Very clean room. Accommodating. Nice and helpful staff.

Reviewed on Mar 11, 2026

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

1802 Gamel Cemetery Road Festus MO

Fully refundable

$135 nightly

$154 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...

9.4/10 Exceptional! (712 reviews)

The room was clean. The people working at the front desk were all very nice. The pool was also nice and very clean.

Reviewed on Mar 1, 2026

Drury Inn & Suites Hayti Caruthersville

1317 E Highway 84 Hayti MO

Fully refundableReserve now, pay when you stay

$94 nightly

$107 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,005 reviews)

Room was clean, beds were super comfortable! Breakfast was ok and the property itself was clean and well taken care of. Lots of lights outside in parking area.

Reviewed on Mar 10, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

Fully refundable

$99 nightly

$112 total

Mar 29 - Mar 30

Total with taxes and fees

A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...

9.4/10 Exceptional! (1,000 reviews)

Clean room staff is very nice parking it great

Reviewed on Mar 6, 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$82 nightly

$93 total

Mar 26 - Mar 27

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...

8.4/10 Very Good! (1,007 reviews)

nice and covenant have stay here a few times, staff always has a smile.

Reviewed on Mar 10, 2026

Comfort Suites Jackson-Cape Girardeau

2904 Old Orchard Rd Jackson MO

Fully refundableReserve now, pay when you stay

$88 nightly

$96 total

Mar 12 - Mar 13

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

8.2/10 Very Good! (750 reviews)

Beds felt amazing. My family and I had a great time

Reviewed on Mar 10, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels With Pools in Southeast Missouri

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

$94 nightly

$108 total

Mar 17 - Mar 18

Total with taxes and fees

9.4/10 Exceptional! (1,001 reviews)

Southeast Missouri Kid-Friendly Hotels

It’s not a family vacation if you can’t bring the entire clan with you, is it? Next time you have a few days off from work, plan a family-friendly getaway. Set off on an adventure the entire family will love, and book your stay at one of the kid-friendly hotels in Southeast Missouri.

Your little ones are the most important thing in your life, so make sure they enjoy your accommodation as much as you do. From a kids-only room service menu (macaroni and cheese, anyone?) to special perks like in-room video game consoles, these lodgings provide a little something extra for the smaller members of your crew. The best family-friendly hotels in Southeast Missouri may even offer playgrounds and other activities to keep the kiddos busy. What’s more, some hotels provide a babysitting service so you can get a few hours to yourself!

Whether you’re traveling with one small child or hauling around your entire extended family, Travelocity is here to help. Let us hook you up with hotels for kids in Southeast Missouri that will keep your youngsters happy without breaking the bank. You can save even more when you bundle your flight and hotel together, so what are you waiting for? Grab your family and get ready to explore!