Explore top 2026 4 Star Hotels in Panama City

Name: Courtyard by Marriott Panama Multiplaza Mall
Price range: $121 total

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

Fully refundable

$128 nightly

$141 total

Oct 6 - Oct 7

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...

8.6/10 Excellent! (2,727 reviews)

"I chose this hotel mainly for the airport shuttle. Not many hotels offered it. The room was very clean, the bed very comfortable. We didn't get to use the pool due to rain during our stay but it was maintained well and very inviting. We had the breakfast buffet with our room rate. The breakfast was ..."

Reviewed on Sep 10, 2026

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama

Fully refundableReserve now, pay when you stay

$183 nightly

$202 total

Oct 11 - Oct 12

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in ...

9/10 Wonderful! (1,006 reviews)

Reviewed on Sep 10, 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Via Espana 111 Panama City Panama

Fully refundableReserve now, pay when you stay

$94 nightly

$104 total

Oct 7 - Oct 8

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...

Megapolis Hotel Panamá

Avenida Balboa Panama City

Fully refundableReserve now, pay when you stay

$157 nightly

$173 total

Sep 16 - Sep 17

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,722 reviews)

"Everything was great"

Reviewed on Sep 10, 2026

Waymore Hotel Spa & Casino

Calle Augusto Samuel Boyd y Calle Eusebi Panama City

Fully refundableReserve now, pay when you stay

$131 nightly

$144 total

Sep 11 - Sep 12

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Relax with a drink at the bar/lounge and enjoy free ...

9/10 Wonderful! (1,134 reviews)

"nice clean place and the staff was helpful"

Reviewed on Sep 10, 2026

Dreams Playa Bonita Panama - All Inclusive

KM 7, Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

$278 nightly

$278 total

Oct 1 - Oct 2

Total with taxes and fees

This all-inclusive property features a full-service spa, a nightclub, and 7 restaurants. Spend a day at the beach kayaking, or relax with free beach cabanas ...

Courtyard by Marriott Panama Metromall

Avenida Domingo Diaz via Tocumen San Miguelito Panama

Fully refundableReserve now, pay when you stay

$101 nightly

$111 total

Oct 9 - Oct 10

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

Riande Aeropuerto Hotel & Casino

Vía Tocumen Tocumen Panama

Fully refundableReserve now, pay when you stay

$108 nightly

$119 total

Sep 13 - Sep 14

Total with taxes and fees

This smoke-free resort features a casino, 2 indoor tennis courts, and a restaurant. Bring the family and enjoy the children's pool, playground, and kid-friendly ...

Ramada Plaza by Wyndham Panama Punta Pacifica

Via Israel y Calle 71, San Francisco Panama City Panama

Fully refundableReserve now, pay when you stay

$100 nightly

$110 total

Sep 27 - Sep 28

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9.6/10 Exceptional! (1,340 reviews)

"Location is great. Staff is friendly. Hotel restaurant and bar is the real deal. Food is yummy and cocktails are the best. This hotel is officially the go to accommodation for my friends and I in Panama. See you soon :)."

Reviewed on Sep 10, 2026

Courtyard by Marriott Panama Multiplaza Mall

Via Israel Multiplaza Pacific Mall Panama City Panama

Fully refundableReserve now, pay when you stay

$110 nightly

$121 total

Sep 26 - Sep 27

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

Central Hotel Panama Casco Viejo

5 out of 5

Posted 2 hours ago

Travelocity Verified Review

"The room was clean. I paid extra for the room to be decorated with flowers upon arrival. It was more rose petals than I anticipated. They also put them in the bathtub which was nice although I never use a bathtub in hotel rooms. The downside is they did not clean out the rose petals from the bathtub the next day and it remained in there for the 5 days we were at the hotel. I was worried about draining the bathtub as I did not want the petals to clog the drain. Thankfully, the room has a shower which was my plan. I will note that there is a gap in the door which causes the floor to be wet. There is no way around this. Our floor was wet everyday. However, we used the plentiful towels available in the room to soak it up. Overall, the experience was nice. The food in the hotel is okay. The breakfast buffet is solid with typical breakfast food. The location is great for exploring the city. You are close to everything in the historical part of the city. It was a quick 10-15 minute uber to other area of the city. I would definitely choose this hotel again."

A verified traveler stayed at Central Hotel Panama Casco Viejo