Explore top 2026 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$128 nightly
The price is $141 total per night from May 30 to May 31
$141 total
May 30 - May 31
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,503 reviews)
Personal Muy Atento y Excelente Limpieza de Habitaciones.

Reviewed on May 1, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $100 total per night from May 5 to May 6
$100 total
May 5 - May 6
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (888 reviews)
Yes

Reviewed on May 1, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
Fully refundable
$74 nightly
The price is $81 total per night from May 26 to May 27
$81 total
May 26 - May 27
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
8.6/10 Excellent! (1,000 reviews)
Great Pool Great view

Reviewed on Apr 30, 2026

Opens in a new windowRadisson Hotel Panama Canal
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from May 8 to May 9
$148 total
May 8 - May 9
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,007 reviews)
A little bit far to the center, but really clean and good to relax time

Reviewed on May 1, 2026

Opens in a new windowSheraton Grand Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from May 9 to May 10
$121 total
May 9 - May 10
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,005 reviews)
Location not bad. Hotel needs modernization, too dated, I had to get a plugin air freshener to get the moldy smell out, air conditioning needs replaced very noisy.

Reviewed on Apr 29, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $224 total per night from Jun 1 to Jun 2
$224 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (720 reviews)
This hotel has a ton of character and is one of the coolest I've ever stayed at with a UNESCO designation. Staff was friendly, the water facing view from the room with the square below was really cool, and it's in a central location. Beds were a bit on the firmer side and pillows were really wide. ...

Reviewed on Apr 30, 2026

Opens in a new windowAmerican Trade Hotel
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $129 total per night from May 18 to May 19
$129 total
May 18 - May 19
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
7.8/10 Good! (1,002 reviews)
The hotel is conveniently located with casino, shops and restaurants nearby.The bed was comfortable but the air conditioner could not be adjusted so the room was freezing. There was no hot water in the shower in my room. Every day I had to go to front desk to ask them to address it. Despite the maintenance ...

Reviewed on Apr 30, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from May 26 to May 27
$110 total
May 26 - May 27
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,178 reviews)
Excellent stay, close to urgent care offices

Reviewed on Apr 29, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $118 total per night from May 18 to May 19
$118 total
May 18 - May 19
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,171 reviews)
Always great

Reviewed on Apr 30, 2026

Opens in a new windowNovotel Panama City
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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