Explore top 2026 4 Star Hotels in Panama City

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from May 24 to May 25
$146 total
May 24 - May 25
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,532 reviews)
Clean room, able to check in a little early

Reviewed on May 11, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $108 total per night from May 12 to May 13
$108 total
May 12 - May 13
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (912 reviews)
Breakfast was good. A wide variety of items were on offer. Rooms were large and clean.

Reviewed on May 11, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
Fully refundable
$74 nightly
The price is $81 total per night from May 24 to May 25
$81 total
May 24 - May 25
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
8.6/10 Excellent! (1,014 reviews)
The hotel must of been a beauty in its day. The location and views of the canal were amazing. I feel as if I was treated as a second class guest because I booked through hotels.com. Our room was close to unsalable, needed lots of maintenance. Couldn’t adjust temperature, yes I did ask for assistance ...

Reviewed on May 10, 2026

Opens in a new windowRadisson Hotel Panama Canal
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from May 23 to May 24
$121 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,026 reviews)
Reached around 10:30 am. Checking was at 3 pm. To our surprise,we had access to the room which was a delight to get some rest. Happy for such service.

Reviewed on May 11, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$200 nightly
The price is $222 total per night from Jun 2 to Jun 3
$222 total
Jun 2 - Jun 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (727 reviews)
The staff was wondering

Reviewed on May 5, 2026

Opens in a new windowAmerican Trade Hotel
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$104 nightly
The price is $114 total per night from Jun 1 to Jun 2
$114 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,189 reviews)
El desayuno estuvo excelente pues me encantan las frutas trropicales., cereales, panes y quesos. Todo delicioso. Gracias

Reviewed on May 11, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from May 22 to May 23
$148 total
May 22 - May 23
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,020 reviews)
Wonderful! The service at this hotel is superior!

Reviewed on May 9, 2026

Opens in a new windowSheraton Grand Panama
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $120 total per night from Jun 7 to Jun 8
$120 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9.2/10 Wonderful! (1,188 reviews)
The staff is very professional, the property was very, the beds were comfortable. The breakfast buffet was delicious. I will definitely make this property as my preferred property in Panama.

Reviewed on May 11, 2026

Opens in a new windowNovotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $143 total per night from May 15 to May 16
$143 total
May 15 - May 16
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,008 reviews)
Great location. Room was big and comfortable.

Reviewed on May 11, 2026

Opens in a new windowLas Americas Golden Tower Panama
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity