Explore top 2026 4 Star Hotels in Panama City

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from Jun 15 to Jun 16
$146 total
Jun 15 - Jun 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,551 reviews)
"Room was clean and the bed was comfortable. The staff were helpful. The hotel is located very close to the airport. This was very convenient for me because of my schedule."

Reviewed on May 18, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $101 total per night from May 23 to May 24
$101 total
May 23 - May 24
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (927 reviews)
"Breakfast was great, rooms very clean"

Reviewed on May 19, 2026

Opens in a new windowWaymore Hotel Spa & Casino
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
Fully refundable
$86 nightly
The price is $94 total per night from Jun 4 to Jun 5
$94 total
Jun 4 - Jun 5
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
8.6/10 Excellent! (1,023 reviews)
"NA"

Reviewed on May 14, 2026

Opens in a new windowRadisson Hotel Panama Canal
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from Jun 6 to Jun 7
$121 total
Jun 6 - Jun 7
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,010 reviews)
"Oportunidad en variedad del desayuno"

Reviewed on May 18, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from May 31 to Jun 1
$153 total
May 31 - Jun 1
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,021 reviews)
"Great breakfast"

Reviewed on May 19, 2026

Opens in a new windowLas Americas Golden Tower Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $134 total per night from Jun 7 to Jun 8
$134 total
Jun 7 - Jun 8
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
7.8/10 Good! (1,033 reviews)
"Breakfast was delicious and a lot of choices. The room was clean and tidy. The staff are vey courteous and helpful. The only thing that I notice that when you enter into the room it had a smell like humidity. The pool needs to have a deep cleaning because it has a lot of black spots. Other than that ..."

Reviewed on May 17, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $114 total per night from Jun 1 to Jun 2
$114 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,205 reviews)
"The hotel booked a live 10 piece band on a Monday night one floor above me and the music and base were so loud the walls were vibrating. I had to be up early for a flight and it’s impossible to sleep. no one here seems to care. How does a hotel charge people for a place to sleep and then charge other ..."

Reviewed on May 19, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $258 total per night from Jun 1 to Jun 2
$258 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (736 reviews)
"Very nice and convinced room. Great staff and very helpful. Great location in the heart of old city"

Reviewed on May 18, 2026

Opens in a new windowAmerican Trade Hotel
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from May 29 to May 30
$148 total
May 29 - May 30
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
Opens in a new windowSheraton Grand Panama
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
"Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here"

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity