Book Hotels in Northeast Missouri, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Northeast Missouri hotels
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Dec 9 to Dec 10
$106 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
Was a very nice stay! Bandanas next door is so good!!
Reviewed on Nov 29, 2025
Drury Inn & Suites St. Louis Union Station
201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $142 total per night from Dec 9 to Dec 10
$142 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Clean room. Wonderful staff. And great freebies!!!
Reviewed on Nov 30, 2025
Live by Loews - St.Louis
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $177 total per night from Dec 7 to Dec 8
$177 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Alright a bit pricey. Especially 40 dollars for parking. I'm still waiting on my deposit refund. Have not received it yet.
Reviewed on Nov 25, 2025
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Dec 28 to Dec 29
$153 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.
Reviewed on Dec 2, 2025
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $115 total per night from Dec 14 to Dec 15
$115 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Love the breakfast buffet! Something for everyone. Staff is always friendly and helpful. I plan to stay at this hotel anytime I’m near it. I always feel so welcome.
Reviewed on Nov 30, 2025
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $120 total per night from Dec 8 to Dec 9
$120 total
Dec 8 - Dec 9
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
Great
Reviewed on Dec 2, 2025
Home2 Suites by Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $89 total per night from Dec 11 to Dec 12
$89 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center ...
Great customer service horrible location
Reviewed on Nov 29, 2025
Sonesta ES Suites St. Louis - Chesterfield
15431 Conway Rd Chesterfield MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $108 total per night from Dec 11 to Dec 12
$108 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free ...
The young man at check in was wonderful. Extreme customer service. Very pleasant experience
Reviewed on Nov 24, 2025
Forest Park Hotel by MDR
5915 Wilson Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $109 total per night from Dec 7 to Dec 8
$109 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling for business? Take advantage of the 24-hour business center, ...
My entire room was clean, the staff are nice, the amenities were efficient…
Reviewed on Nov 28, 2025
Don't see what you're looking for?
See all available properties in Northeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Northeast Missouri hotels
Quality Inn St. Louis Airport Hotel
10232 Natural Bridge Rd St. Louis MO
$55 nightly
The price is $64 total per night from Dec 14 to Dec 15
$64 total
Dec 14 - Dec 15
Total with taxes and fees
6/10 (1,005 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Northeast Missouri with star-rating
Check Northeast Missouri Hotels by Star Rating
5 Star Hotels
1 properties
Recent Northeast Missouri hotel reviews by fellow wanderers
21C Museum Hotel St Louis
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area. "
A verified traveler stayed at 21C Museum Hotel St Louis
Explore More Ways to Travel with Travelocity
- Hotels near Long Branch State Park
- Hotels near Union Covered Bridge States Historic Site
- Lodges in Hurdland
- Farmstay in Shelbyville
- Shelbyville Hotels
- Motels in Shelbyville
- Edina Hotels
- Lodges in Edina
- Hotels near Mark Twain Lake
- Hotels near Mark Twain Casino
- 5 Star Hotels in Monroe City
- Farmstay in Monroe City
- B&B in Monroe City
- Cabins in Monroe City
- Condos in Monroe City
- Monroe City Hotels
- Motels in Monroe City
- Vacation Homes in Monroe City
- Maywood Hotels
- Atlanta Hotels
- Hotels near Truman State University
- La Grange Hotels
- Rutledge Hotels
- Hotels near Stephen's Park
- Gibbs Hotels
- Hotels near Jackson Street Park
- Stoutsville Hotels
- Canton Hotels
- B&B in Shelbina
- Cabins in Shelbina
- Shelbina Hotels
- Motels in Shelbina
- Vacation Homes in Shelbina
- Hotels near Wakonda State Park
- Bevier Hotels
- Hotels near La Plata Golf Course
- Paris Hotels
- Palmyra Hotels
- Hotels near Kirksville Municipal
- 4 Star Hotels in Hunnewell
- Cabins in Hunnewell
- Motels in Hunnewell
- Taylor Hotels
- Hotels near Mark Twain State Park
- Historic Hotels in La Plata
- Hotels with a Gym in La Plata
- La Plata Hotels
- Hotels near Mark Twain Birthplace State Historic Site
- 3 Star Hotels in Macon
- Apartments in Macon
- Cabins in Macon
- Cottages in Macon
- Cheap Hotels in Macon
- Golf Resorts & in Macon
- Historic Hotels in Macon
- Hotels with Pools in Macon
- Hotels with Hot Tubs in Macon
- Hotels with an Indoor Pool in Macon
- Pet Friendly Hotels in Macon
- Macon Hotels
- Lodges in Macon
- Motels in Macon
- Vacation Homes in Macon
- Holliday Hotels
- Flights to Monroe City
- Flights to Shelbina
- Flights from Kirksville Municipal
- American Airlines Springfield (SPI) to Kirksville (IRK) flights
- American Airlines Albuquerque (ABQ) to Kirksville (IRK) flights
- American Airlines Dallas (DFW) to Kirksville (IRK) flights
- American Airlines Fort Lauderdale (FLL) to Kirksville (IRK) flights
- American Airlines Chicago (ORD) to Kirksville (IRK) flights
- Cape Air St. Louis (STL) to Kirksville (IRK) flights
- Cape Air Chicago (ORD) to Kirksville (IRK) flights
- Delta Atlanta (ATL) to Kirksville (IRK) flights
- United Indianapolis (IND) to Kirksville (IRK) flights
- Flights from Augusta (AGS) to Kirksville (IRK)
- Flights from Albany (ALB) to Kirksville (IRK)
- Flights from Burlington (BTV) to Kirksville (IRK)
- Flights from Columbia (COU) to Kirksville (IRK)
- Flights from Detroit (DTW) to Kirksville (IRK)
- Flights from Grand Rapids (GRR) to Kirksville (IRK)
- Flights from Jacksonville (JAX) to Kirksville (IRK)
- Flights from Kansas City (MCI) to Kirksville (IRK)
- Flights from Orlando (MCO) to Kirksville (IRK)
- Flights from Minneapolis (MSP) to Kirksville (IRK)
- Flights from Omaha (OMA) to Kirksville (IRK)
- Flights from Chicago (ORD) to Kirksville (IRK)
- Flights from Louisville (SDF) to Kirksville (IRK)
- Flights from St. Louis (STL) to Kirksville (IRK)
- Flights from Tri-Cities (TRI) to Kirksville (IRK)
- Flights to Macon
