Explore Southern Illinois Spa Hotels & Wellness Resorts

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Southern Illinois Spa Resorts & Hotels

Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St, Marion, IL
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $78 total per night
$78 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Free Cancellation
Reserve now, pay when you stay
$93 nightly
The price is $106 total per night
$106 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street, Mount Vernon, IL
Free Cancellation
Reserve now, pay when you stay
$119 nightly
The price is $134 total per night
$134 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 out of 5
1200 N Raney, Effingham, IL
Free Cancellation
$92 nightly
The price is $102 total per night
$102 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

2.5 out of 5
2179 East 5th Street, Metropolis, IL
Free Cancellation
$91 nightly
The price is $101 total per night
$101 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Clarion Pointe Mattoon near University

Clarion Pointe Mattoon near University

2.5 out of 5
206 Mcfall Rd, Mattoon, IL
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $105 total per night
$105 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free ...
Best Western Marion Hotel

Best Western Marion Hotel

2.5 out of 5
400 Comfort Dr, Marion, IL
Free Cancellation
Reserve now, pay when you stay
$83 nightly
The price is $100 total per night
$100 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50, O'Fallon, IL
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $66 total per night
$66 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Baymont by Wyndham Metropolis

Baymont by Wyndham Metropolis

2.5 out of 5
203 E Front St, Metropolis, IL
Get rates
This motel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Americas Best Value Inn Mount Vernon

Americas Best Value Inn Mount Vernon

2.5 out of 5
222 South 44th Street, Mount Vernon, IL
Free Cancellation
Reserve now, pay when you stay
$64 nightly
The price is $72 total per night
$72 total
Oct 19 - Oct 20
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
Days Inn by Wyndham Pontoon Beach

Days Inn by Wyndham Pontoon Beach

2 out of 5
5105 Highway 111, Granite City, IL
Free Cancellation
Reserve now, pay when you stay
$56 nightly
The price is $62 total per night
$62 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate freebies like continental ...
Days Inn & Suites by Wyndham Caseyville

Days Inn & Suites by Wyndham Caseyville

2.5 out of 5
2423 Old Country Inn Drive, Caseyville, IL
Free Cancellation
Reserve now, pay when you stay
$53 nightly
The price is $60 total per night
$60 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Don't see what you're looking for?
See all available properties in Southern Illinois
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southern Illinois Spa Hotels

Are you looking for a break from the hustle and bustle of your day-to-day life? Do you want to escape reality and forget about your never ending to-do list? Then why not treat yourself to a relaxing stay at one of the spa hotels in Southern Illinois? Whether it is for a weekend getaway or a staycation, book your visit to one of the Southern Illinois luxury spa hotels.

With all of the amazing things to do around Southern Illinois, you will likely be worn out from sightseeing. The Southern Illinois spa hotels provide top of the line facilities with hot-tubs, saunas and private treatment rooms. Treat yourself to an indulgent hot stone massage or facial to rejuvenate from a busy day. If that's not enough for you, indulge in a full day-at-the-spa package. And maybe you are just looking to reach maximum relaxation before a fancy night out on the town. Take advantage of the salon features offered at most Southern Illinois spa hotels and get a mani-pedi before your evening begins. 

Travelocity wants to help you relax and rejuvenate during your next stay in Southern Illinois, but we know that spa treatments can put some strain on your wallet. Bundle your hotel and flight together and save enough to pay for your facial!

Southern Illinois hotels essential information

Accommodation
1,083 hotels
Lowest Price
$60
Highest Price
$134
Popular hotels
Drury Inn & Suites St. Louis Fairview Heights, Drury Inn & Suites Marion, Holiday Inn Express Metropolis by IHG, Comfort Suites Mount Vernon, Quality Inn O'Fallon IL - St. Louis, Country Inn & Suites by Radisson, Effingham, IL, Days Inn by Wyndham Pontoon Beach, Baymont by Wyndham Metropolis, Days Inn & Suites by Wyndham Caseyville, Americas Best Value Inn Mount Vernon, Clarion Pointe Mattoon near University, Best Western Marion Hotel

Recent Southern Illinois hotel reviews by fellow wanderers

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Everything sparkled. "
A verified traveler stayed at Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon

Explore More Ways to Travel with Travelocity