Explore 38 Luxury Hotels in Upstate South Carolina

Name: Quality Inn Clemson near University
Price range: $58 total
Rating: 7

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Best Luxury Hotels in Upstate South Carolina

The Bleckley Inn

151 E Church St Anderson SC

$247 nightly

$274 total

Mar 17 - Mar 18

Total with taxes and fees

A restaurant and a gym are featured at this hotel. Business travelers can take advantage of the free WiFi in public areas. Enjoy the a rooftop terrace and perks ...

9.8/10 Exceptional! (410 reviews)

Wonderful staff and the room was clean. Hotel is absolutely beautiful

Reviewed on Feb 7, 2026

The Westin Poinsett Greenville

120 South Main St Greenville SC

$189 nightly

$208 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,000 reviews)

I think the

Reviewed on Mar 4, 2026

Hyatt Regency Greenville

220 N Main St Greenville SC

$149 nightly

$163 total

Mar 22 - Mar 23

Total with taxes and fees

This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

8.8/10 Excellent! (1,000 reviews)

Great location, very nice staff.

Reviewed on Mar 10, 2026

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

851 Congaree Rd Greenville SC

Fully refundable

$99 nightly

$109 total

Apr 12 - Apr 13

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

8.6/10 Excellent! (1,006 reviews)

Nice stay. Clean, friendly. The property could be updated along with amenities, with microwaves in the room but it’s a good hotel overall.

Reviewed on Mar 13, 2026

Sleep Inn at Greenville Convention Cente

231 N Pleasantburg Dr Greenville SC

Fully refundable

$73 nightly

$80 total

Apr 2 - Apr 3

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...

8/10 Very Good! (1,000 reviews)

Clean, convenient and usually affordable

Reviewed on Mar 12, 2026

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

65 W Orchard Park Dr Greenville SC

Fully refundableReserve now, pay when you stay

$71 nightly

$78 total

Mar 26 - Mar 27

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...

7.4/10 Good! (1,119 reviews)

We did book through an online alternate site vs directly so dinner make a difference? we were given a handicapped room which we didn’t request. But no problem with that- had nice feature such as door peek hole at right level, large bathroom. But room condition was just ok. Toilet bowl didn’t leak ...

Reviewed on Mar 8, 2026

Red Roof Inn Spartanburg – I-26

6765 Pottery Rd Spartanburg SC

Fully refundableReserve now, pay when you stay

$61 nightly

$67 total

Mar 29 - Mar 30

Total with taxes and fees

This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. Staff at the 24-hour ...

7/10 Good! (752 reviews)

Almost perfect. Everyone was very nice and friendly and helpful. The refrigerator in the room had stuff spilled in it that we had to clean before using it. There was nothing in the soap, shampoo, conditioner and lotion bottles. Fortunately I had those things in my luggage and the guy at the front ...

Reviewed on Feb 15, 2026

Quality Inn Clemson near University

3430 Clemson Blvd Anderson SC

Fully refundableReserve now, pay when you stay

$52 nightly

$58 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

7/10 Good! (903 reviews)

The room was disgusting. Stained rugs, odor in the room, cigarette ashes on the lamp shades. Broken outlets, holes in walls, door was broken and latch was loose.

Reviewed on Mar 9, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Upstate South Carolina

Park Place Apartments by Landing

31 Victor St Greenville SC

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7.6/10 Good! (46 reviews)

Upstate South Carolina Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Upstate South Carolina luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Upstate South Carolina to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Upstate South Carolina will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Upstate South Carolina, and plan your next opulent escape.

Upstate South Carolina hotels essential information

Accommodation	2,946 hotels
Lowest Price	$58
Highest Price	$461
Popular hotels	The Westin Poinsett Greenville, Hyatt Regency Greenville, Sleep Inn at Greenville Convention Cente, The Bleckley Inn, Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG, Red Roof Inn Spartanburg – I-26, Quality Inn Clemson near University, La Quinta by Wyndham Haywood Mall-Near Greenville Downtown