Explore 38 Luxury Hotels in Upstate South Carolina
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Best Luxury Hotels in Upstate South Carolina
The Bleckley Inn
151 E Church St Anderson SC
The price is $211 total per night from Nov 30 to Dec 1
$211 total
per night
Nov 30 - Dec 1
A restaurant and a gym are featured at this hotel. Business travelers can take advantage of the free WiFi in public areas. Enjoy the a rooftop terrace and perks ...
9.6/10 Exceptional! (405 reviews)
Courteous staff, quiet, beautiful accommodations and great location in Downtown Anderson.
Reviewed on Nov 7, 2025
The Westin Poinsett Greenville
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
The price is $175 total per night from Dec 22 to Dec 23
$175 total
per night
Dec 22 - Dec 23
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
9.2/10 Wonderful! (1,002 reviews)
Beautiful and historical building. On a Main Street surrounded by restaurants and only a block walk to Falls Park.
Reviewed on Nov 18, 2025
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
The price is $153 total per night from Nov 24 to Nov 25
$153 total
per night
Nov 24 - Nov 25
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (1,000 reviews)
The room was clean and the location was perfect to all of the downtown attractions
Reviewed on Nov 16, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
The price is $92 total per night from Dec 21 to Dec 22
$92 total
per night
Dec 21 - Dec 22
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.4/10 Very Good! (1,001 reviews)
Yes
Reviewed on Nov 18, 2025
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr Greenville SC
Fully refundable
The price is $91 total per night from Nov 25 to Nov 26
$91 total
per night
Nov 25 - Nov 26
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...
7.8/10 Good! (1,001 reviews)
Room was very clean and quiet. Bathroom could use some touchups. I did not eat until 8;30 so food was ok by then. Good location.
Reviewed on Nov 6, 2025
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
The price is $72 total per night from Dec 14 to Dec 15
$72 total
per night
Dec 14 - Dec 15
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
7.2/10 Good! (1,114 reviews)
Ac was great. Room was clean. Bed was very comfortable. Really enjoyed our stay.
Reviewed on Nov 17, 2025
Red Roof Inn Spartanburg – I-26
6765 Pottery Rd Spartanburg SC
Fully refundableReserve now, pay when you stay
The price is $75 total per night from Dec 7 to Dec 8
$75 total
per night
Dec 7 - Dec 8
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. Staff at the 24-hour ...
6.8/10 (732 reviews)
Staff
Reviewed on Nov 9, 2025
Quality Inn Clemson near University
3430 Clemson Blvd Anderson SC
Fully refundableReserve now, pay when you stay
The price is $56 total per night from Nov 30 to Dec 1
$56 total
per night
Nov 30 - Dec 1
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...
6.8/10 (886 reviews)
Shopping is good nears around
Reviewed on Sep 27, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Upstate South Carolina
Liberty Hall Bed and Breakfast
621 S Mechanic St Pendleton SC
The price is $233 total per night from Dec 8 to Dec 9
$233 total
per night
Dec 8 - Dec 9
9.8/10 Exceptional! (76 reviews)
Upstate South Carolina Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Upstate South Carolina luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Upstate South Carolina to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Upstate South Carolina will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Upstate South Carolina, and plan your next opulent escape.
Upstate South Carolina hotels essential information
Accommodation | 2,885 hotels |
|---|---|
Lowest Price | $56 |
Highest Price | $450 |
Popular hotels | The Westin Poinsett Greenville, Hyatt Regency Greenville, Sleep Inn at Greenville Convention Cente, The Bleckley Inn, Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG, Red Roof Inn Spartanburg – I-26, Quality Inn Clemson near University, La Quinta Inn & Suites by Wyndham Greenville Haywood |
Popular Luxury Stays in Upstate South Carolina
Recent Upstate South Carolina Hotel Reviews By Fellow Wanderers
Embassy Suites Greenville Golf Resort & Conference Center
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Great hotel"
A verified traveler stayed at Embassy Suites Greenville Golf Resort & Conference Center
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