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Top Byron hotels

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$121 nightly
The price is $139 total per night from Aug 1 to Aug 2
$139 total
Aug 1 - Aug 2
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Great staff and room, loved the parking"

Reviewed on Jul 5, 2026

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $172 total per night from Jul 9 to Jul 10
$172 total
Jul 9 - Jul 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"The good: Clean room, comfortable bed, very kind staff, great breakfast, convenient parking garage. The bad: Wall outlets in the room were all very loose and nothing would stay plugged in (the weight of the plug would cause it to fall out). There were no bath towels in the room (I assume the cleaning ..."

Reviewed on Jul 1, 2026

Opens in a new windowHyatt House Rochester/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Jul 12 to Jul 13
$131 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"Clean room . Basic breakfast. Friendly staff."

Reviewed on Jul 5, 2026

Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $148 total per night from Jul 31 to Aug 1
$148 total
Jul 31 - Aug 1
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Staff were always friendly and helpful. Hot tub and pool were a plus for me. Did not need to go outside for any of my appointments at Mayo Clinic. Easy access to everything. Lord Essex restaurant has a great breakfast. Highly recommend the Kahler Grand Hotel."

Reviewed on Jul 3, 2026

Opens in a new windowKahler Grand Hotel
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $91 total per night from Jul 12 to Jul 13
$91 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
"Clean room and entire hotel was clean! Great breakfast! Staff are wonderful!"

Reviewed on Jul 5, 2026

Opens in a new windowBest Western Rochester Hotel Mayo Clinic Area/St. Mary's
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Jul 6 to Jul 7
$160 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
"Room was clean. Staff was hopeful. Complementary breakfast was good. Parking space appreciated and rate was not terrible. However, it is a very tight lot."

Reviewed on Jul 3, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Jul 6 to Jul 7
$97 total
Jul 6 - Jul 7
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
"It was an OK stay for the value. Pricepoint for the Two Queen Studio Kitchenette was great. The room we had, the stovetop was 2 burners right by the sink, did not use those cause of preference. Was not appealing to use. Fridge was full size and great and we made use of that. Microwave was standard. ..."

Reviewed on Jul 4, 2026

Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $87 total per night from Jul 12 to Jul 13
$87 total
Jul 12 - Jul 13
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"M"

Reviewed on Jul 4, 2026

Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from Jul 12 to Jul 13
$87 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel's 3 indoor pools and gym are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"They help make your stay quiet and relaxing. It’s very clean and staff is friendly and helpful. I was going to Mayo and the shuttle is very nice and convenient so you don’t have to pay or drive down there. I’ve stayed at this location several times and I always go back because they take care of the ..."

Reviewed on Jul 5, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Byron?
Take some of the worries out of traveling with youngsters by choosing a family-friendly hotel in Byron. From thoughtful amenities to services that bring a smile, these stays offer perks that'll help make your getaway run like a dream: Put your bags down at Luxury Custom Home in Golf Community. It comes with a fireplace, pet-friendly facilities and a flair for making families feel welcome. Also check out the deals at Rochesters Relaxing Ranch - 4 miles from Mayo. It comes with a king bed, free WiFi and ample opportunities for precious family time.
Where can I find cheap hotels in Byron?
At Travelocity you'll find really nice hotels in Byron at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Byron rather than in Byron. We may find you even better rates, too.
How do I find the best Byron hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Byron then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Byron?
The cheapest hotel in Byron is $87. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Byron?
There are 373 hotels in Byron on Travelocity.
What are the best hotels in Byron?
Byron has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Byron for you!
When is the best time to visit Byron?
If you want the joy of a fun-filled trip in peak season, visit Byron during March, May and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Byron?
Based on historic data is usually the cheapest month to visit Byron. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Byron?
There are multiple hotels in Byron that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Byron. We have plenty of kid-friendly hotels in Byron to choose from on Travelocity!
Why book a hotel in Byron through Travelocity?
Because we have the top hotels in Byron! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Byron on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Byron hotel reviews by fellow wanderers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Clean room and entire hotel was clean! Great breakfast! Staff are wonderful!"
A verified traveler stayed at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

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