American Airlines Flight AA5381 Deals & Information (2025/2026)

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American Airlines Flight 5381 Route Deals From $189

The cheapest prices found with in the last 7 days for return flights were $367 and $189 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$367 Roundtrip, found 22 hours ago
$367
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $367 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$372 Roundtrip, found 22 hours ago
$372
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $372 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$383 Roundtrip, found 22 hours ago
$383
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $383 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$387 Roundtrip, found 22 hours ago
$387
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $387 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$389 Roundtrip, found 22 hours ago
$389
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $389 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$392 Roundtrip, found 22 hours ago
$392
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $392 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$407 Roundtrip, found 22 hours ago
$407
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $407 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$412 Roundtrip, found 22 hours ago
$412
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $412 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$449 Roundtrip, found 22 hours ago
$449
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $449 found 22 hours ago
Thu, Jul 17 - Tue, Jul 22
GSP
Greenville-Spartanburg Intl.
CLT
Charlotte-Douglas Intl.
$451 Roundtrip, found 22 hours ago
$451
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from Greenville-Spartanburg Intl. to Charlotte-Douglas Intl., returning Tue, Jul 22, priced at $451 found 22 hours ago

Frequently asked questions

What route does flight number AA5381 take?
AA5381 is used on a range of routes. Most commonly, AA5381 flies direct from GSP to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). If that’s your flight path, you’ll be in the air for around 1 hour and 16 minutes.
What kind of plane is on flight number AA5381?
AA5381 is a flight number that’s used on many routes. If you’re booked on the most popular one, Greenville-Spartanburg Intl. Airport (GSP) to Charlotte Airport, there’s a good chance you’ll be climbing on board a Bombardier CRJ900.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5381 flight with Travelocity, please visit our Customer Service Portal.