American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $169

The cheapest prices found with in the last 7 days for return flights were $316 and $169 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Dec 7 - Fri, Dec 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$316 Roundtrip, found 2 days ago
$316
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Dec 7 from LaGuardia to Buffalo Niagara Intl., returning Fri, Dec 11, priced at $316 found 2 days ago
Mon, Dec 7 - Fri, Dec 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$326 Roundtrip, found 2 days ago
$326
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Dec 7 from LaGuardia to Buffalo Niagara Intl., returning Fri, Dec 11, priced at $326 found 2 days ago
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$328 Roundtrip, found 2 days ago
$328
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $328 found 2 days ago
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$338 Roundtrip, found 2 days ago
$338
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $338 found 2 days ago
Fri, Nov 13 - Sat, Nov 14
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$343 Roundtrip, just found
$343
Roundtrip
just found
Select American Airlines flight, departing Fri, Nov 13 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 14, priced at $343 just found
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$349 Roundtrip, found 2 days ago
$349
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $349 found 2 days ago
Tue, Dec 8 - Wed, Dec 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$357 Roundtrip, found 21 hours ago
$357
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Dec 8 from LaGuardia to Buffalo Niagara Intl., returning Wed, Dec 9, priced at $357 found 21 hours ago
Wed, Nov 4 - Wed, Nov 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$360 Roundtrip, found 2 days ago
$360
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Nov 4 from LaGuardia to Buffalo Niagara Intl., returning Wed, Nov 11, priced at $360 found 2 days ago
Fri, Nov 13 - Sat, Nov 14
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$363 Roundtrip, just found
$363
Roundtrip
just found
Select American Airlines flight, departing Fri, Nov 13 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 14, priced at $363 just found
Fri, Nov 13 - Sun, Nov 15
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$374 Roundtrip, just found
$374
Roundtrip
just found
Select American Airlines flight, departing Fri, Nov 13 from LaGuardia to Buffalo Niagara Intl., returning Sun, Nov 15, priced at $374 just found
Fri, Nov 6 - Sat, Nov 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$377 Roundtrip, found 17 hours ago
$377
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 7, priced at $377 found 17 hours ago
Tue, Dec 8 - Wed, Dec 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$384 Roundtrip, found 21 hours ago
$384
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Dec 8 from LaGuardia to Buffalo Niagara Intl., returning Wed, Dec 9, priced at $384 found 21 hours ago
Fri, Nov 6 - Sat, Nov 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$387 Roundtrip, found 17 hours ago
$387
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 7, priced at $387 found 17 hours ago
Fri, Nov 27 - Mon, Nov 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$409 Roundtrip, found 17 hours ago
$409
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Nov 27 from LaGuardia to Buffalo Niagara Intl., returning Mon, Nov 30, priced at $409 found 17 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.