American Airlines Flight AA4521 Deals & Information (2025/2026)

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American Airlines Flight 4521 Route Deals From $70

The cheapest prices found with in the last 7 days for return flights were $147 and $70 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 15 - Sat, Oct 18
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$147 Roundtrip, found 23 hours ago
$147
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 15 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 18, priced at $147 found 23 hours ago
Wed, Oct 15 - Sat, Oct 18
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$155 Roundtrip, found 23 hours ago
$155
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 15 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 18, priced at $155 found 23 hours ago
Tue, Oct 21 - Tue, Oct 28
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$157 Roundtrip, found 4 days ago
$157
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 21 from LaGuardia to Buffalo Niagara Intl., returning Tue, Oct 28, priced at $157 found 4 days ago
Wed, Jul 23 - Thu, Jul 24
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$167 Roundtrip, found 3 days ago
$167
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 23 from LaGuardia to Buffalo Niagara Intl., returning Thu, Jul 24, priced at $167 found 3 days ago
Mon, Aug 25 - Fri, Aug 29
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$172 Roundtrip, found 1 day ago
$172
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Aug 25 from LaGuardia to Buffalo Niagara Intl., returning Fri, Aug 29, priced at $172 found 1 day ago
Thu, Jul 31 - Mon, Aug 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$176 Roundtrip, found 5 hours ago
$176
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Jul 31 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 4, priced at $176 found 5 hours ago
Sat, Sep 20 - Mon, Sep 22
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$183 Roundtrip, found 3 days ago
$183
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Sep 20 from LaGuardia to Buffalo Niagara Intl., returning Mon, Sep 22, priced at $183 found 3 days ago
Mon, Jun 23 - Mon, Jun 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$185 Roundtrip, found 6 days ago
$185
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jun 23 from LaGuardia to Buffalo Niagara Intl., returning Mon, Jun 30, priced at $185 found 6 days ago
Thu, Oct 16 - Sat, Oct 18
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$195 Roundtrip, found 23 hours ago
$195
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Oct 16 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 18, priced at $195 found 23 hours ago
Mon, Jul 7 - Tue, Jul 8
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$196 Roundtrip, found 11 hours ago
$196
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Mon, Jul 7 from LaGuardia to Buffalo Niagara Intl., returning Tue, Jul 8, priced at $196 found 11 hours ago
Tue, Aug 26 - Sat, Aug 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$197 Roundtrip, found 1 day ago
$197
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Aug 26 from LaGuardia to Buffalo Niagara Intl., returning Sat, Aug 30, priced at $197 found 1 day ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you’ll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you’ve booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there’s a strong chance you’ll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.