American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $111

The cheapest prices found with in the last 7 days for return flights were $197 and $111 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 1 - Thu, Sep 3
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$197 Roundtrip, found 6 days ago
$197
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 1 from LaGuardia to Buffalo Niagara Intl., returning Thu, Sep 3, priced at $197 found 6 days ago
Thu, Aug 20 - Mon, Aug 24
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$205 Roundtrip, found 6 days ago
$205
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Aug 20 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 24, priced at $205 found 6 days ago
Thu, Oct 8 - Sun, Oct 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$217 Roundtrip, found 10 hours ago
$217
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Thu, Oct 8 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 11, priced at $217 found 10 hours ago
Fri, Jul 3 - Fri, Jul 10
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$221 Roundtrip, found 10 hours ago
$221
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Fri, Jul 3 from LaGuardia to Buffalo Niagara Intl., returning Fri, Jul 10, priced at $221 found 10 hours ago
Wed, Jul 8 - Thu, Jul 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 8 from LaGuardia to Buffalo Niagara Intl., returning Thu, Jul 9, priced at $228 found 2 days ago
Thu, Aug 20 - Mon, Aug 24
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$231 Roundtrip, found 6 days ago
$231
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Aug 20 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 24, priced at $231 found 6 days ago
Tue, Sep 22 - Sat, Sep 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$232 Roundtrip, found 1 day ago
$232
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 22 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 26, priced at $232 found 1 day ago
Sun, Aug 9 - Mon, Aug 10
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$236 Roundtrip, found 4 days ago
$236
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Aug 9 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 10, priced at $236 found 4 days ago
Sat, Sep 12 - Mon, Sep 14
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 12 from LaGuardia to Buffalo Niagara Intl., returning Mon, Sep 14, priced at $237 found 1 day ago
Tue, Jun 30 - Sat, Jul 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$238 Roundtrip, found 6 days ago
$238
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jun 30 from LaGuardia to Buffalo Niagara Intl., returning Sat, Jul 4, priced at $238 found 6 days ago
Thu, Aug 20 - Mon, Aug 24
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$241 Roundtrip, found 6 days ago
$241
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Aug 20 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 24, priced at $241 found 6 days ago
Sat, Sep 12 - Mon, Sep 14
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 12 from LaGuardia to Buffalo Niagara Intl., returning Mon, Sep 14, priced at $247 found 1 day ago
Fri, Aug 7 - Sun, Aug 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$249 Roundtrip, found 4 days ago
$249
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 7 from LaGuardia to Buffalo Niagara Intl., returning Sun, Aug 9, priced at $249 found 4 days ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.