Explore top 2025 5 Star Hotels in Panama City

Name: Hilton Panama
Price range: $254 total
Rating: 8.8

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Top Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella, Panama City, Panama

Fully refundableReserve now, pay when you stay

$119 nightly

$131 total

Oct 5 - Oct 6

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (4,360 reviews)

"Great free breakfast too, staff is always friendly and ready to help."

Reviewed on Sep 29, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

$224 nightly

$247 total

Oct 25 - Oct 26

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,007 reviews)

"Microwave in the room"

Reviewed on Sep 21, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica, Panama City, Panama

Fully refundableReserve now, pay when you stay

$229 nightly

$252 total

Oct 12 - Oct 13

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,014 reviews)

"Property of HUGE"

Reviewed on Sep 27, 2025

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Veracruz, Panama

Fully refundableReserve now, pay when you stay

$149 nightly

$164 total

Oct 13 - Oct 14

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,007 reviews)

"The staff is exceptional! From the room maids, to the staff at the restaurants, to the bar tenders, to the room service, to the pool guys - 5 star service!! The rooms and entire facility was always clean and modern! Be sure to rent a car if you don't get all-inclusive! Only advice is to have more ..."

Reviewed on Oct 1, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe, Panama City, Panama

Fully refundableReserve now, pay when you stay

$315 nightly

$347 total

Oct 14 - Oct 15

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (512 reviews)

"Amazing ✨✨✨✨"

Reviewed on Sep 18, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

$103 nightly

$113 total

Oct 10 - Oct 11

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (65 reviews)

"The Room was very clean, all staff were very kind and professional, the breakfast and dinner are so delicious, nothing comparative with other restaurant around."

Reviewed on Sep 22, 2025

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard, Panama City

Fully refundableReserve now, pay when you stay

$221 nightly

$243 total

Oct 10 - Oct 11

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (609 reviews)

"Clean, well designed rooms. Soft king bed and pillows, desk, nice shower with rain showerhead. Golf course was hard to navigate without knowing itslayout as a visitor, but nice course though. Wish there was more casual resturants open by pool on Sundays or anyday for relaxing time. More formal dress ..."

Reviewed on Sep 29, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City

Fully refundableReserve now, pay when you stay

$179 nightly

$197 total

Oct 31 - Nov 1

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

8.8/10 Excellent! (1,009 reviews)

"Staff was congenial and quite accomodating. Really nice amenities and a terrific buffet breakfast."

Reviewed on Sep 27, 2025

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

$124 nightly

$136 total

Oct 3 - Oct 4

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,013 reviews)

"Excelent atention to detail, recomended stay."

Reviewed on Sep 20, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City

Fully refundableReserve now, pay when you stay

$231 nightly

$254 total

Oct 11 - Oct 12

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,008 reviews)

"Amazing stay they accommodated me with looking for a room that i was comfortable with . I saw about 8 rooms till i was content . Amazing service , breakfast was great . Restaurant was amazing . Would definitely return ."

Reviewed on Sep 28, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panama City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.