Explore the best 2025 4 Star Hotels Hotels in Lower Florida Keys

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Lower Florida Keys 4 Star hotels

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$289 nightly
The price is $325 total per night
$325 total
Jun 17 - Jun 18
Total includes taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling for business? Take advantage of the 24-hour business center, laundry service, and conference space.
Pool
Spa
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

4 out of 5
5950 Peninsular Avenue, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$220 nightly
The price is $247 total per night
$247 total
Jun 15 - Jun 16
Total includes taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. The restaurant provides options for dining, while the bar/lounge and poolside bar are great spots to unwind.
Pool
Pet friendly
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Boulevard, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$234 nightly
The price is $264 total per night
$264 total
Jun 30 - Jul 1
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including food and water bowls. There's a 24-hour gym on site, and a 24-hour front desk and dry cleaning are also provided.
Pool
Pet friendly
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

4 out of 5
430 Duval St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$259 nightly
The price is $288 total per night
$288 total
Jun 16 - Jun 17
Total includes taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and valet parking. There's a poolside bar on site, and a 24-hour front desk and concierge services are also provided.
Pool
Pet friendly
The Perry Hotel & Marina Key West

The Perry Hotel & Marina Key West

4 out of 5
7001 Shrimp Road, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$210 nightly
The price is $236 total per night
$236 total
Jun 3 - Jun 4
Total includes taxes and fees
A marina, 2 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, and conference space. 2 poolside bars and 2 bars/lounges are featured at this hotel, along with a 24-hour gym.
Pool
Pet friendly
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

4 out of 5
601 Front St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$341 nightly
The price is $384 total per night
$384 total
Jun 30 - Jul 1
Total includes taxes and fees
This eco-certified resort features a full-service spa, a marina, and a restaurant. Enjoy the outdoor pool and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Pool
Spa
Pier House Resort & Spa

Pier House Resort & Spa

4 out of 5
1 Duval St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$487 nightly
The price is $548 total per night
$548 total
Jun 2 - Jun 3
Total includes taxes and fees
This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.
On private beach
Pool
The Gates Hotel Key West Newly Renovated

The Gates Hotel Key West Newly Renovated

4 out of 5
3824 N Roosevelt Blvd, Key West, FL
Get rates
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. There's a poolside bar on site, and laundry facilities and concierge services are also provided.
Pool
Pet friendly
Havana Cabana at Key West

Havana Cabana at Key West

4 out of 5
3420 N. Roosevelt Blvd, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$192 nightly
The price is $216 total per night
$216 total
Jun 2 - Jun 3
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and perks like free self parking.
Pool
Hot Tub
Parrot Key Hotel & Villas

Parrot Key Hotel & Villas

4 out of 5
2801 N Roosevelt Blvd, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$210 nightly
The price is $236 total per night
$236 total
Jun 8 - Jun 9
Total includes taxes and fees
This eco-certified hotel features 4 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Unwind with a drink at the bar/lounge and enjoy perks like a free area shuttle.
Pool
Free WiFi
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$352 nightly
The price is $396 total per night
$396 total
Jun 22 - Jun 23
Total includes taxes and fees
This resort features a private beach, a full-service spa, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, and valet parking. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.
On private beach
Pool
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

4 out of 5
1500 Reynolds Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
$357 nightly
The price is $402 total per night
$402 total
Jun 11 - Jun 12
Total includes taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off with a drink at the beachside bar. Enjoy the gym and perks like free WiFi.
On private beach
Pool
Don't see what you're looking for?
See all available properties in Lower Florida Keys
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Lower Florida Keys

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Lower Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Lower Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Lower Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Lower Florida Keys hotels essential information

Accommodation
3,475 hotels
Lowest Price
$216
Highest Price
$548
Popular hotels
Southernmost Beach Resort and Guesthouses, Oceans Edge Key West Resort, Hotel & Marina, Margaritaville Beach House Key West, La Concha Key West, Autograph Collection, The Perry Hotel & Marina Key West, Hyatt Centric Key West Resort and Spa, Pier House Resort & Spa, The Gates Hotel Key West Newly Renovated, Havana Cabana at Key West , Parrot Key Hotel & Villas, The Reach Key West, Curio Collection by Hilton, Casa Marina Key West, Curio Collection by Hilton

Recent Lower Florida Keys hotel reviews by fellow wanderers

Sugarloaf Key Hotel at KOA Resort

Sugarloaf Key Hotel at KOA Resort

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Such beautiful accomdations away from the craziness of Key West, yet closer enough to visit and enjoy all of the attractions, in Key West, Marathon, and throughout the lower Keys! The room was beautiful and clean, the pool and ajacent bar absolutely picture perfect, and the bar evening activities very fun. The private beach was gorgeous, and the marina full of fun outdoor items to rent and enjoy and explore! (The marina staff was SO friendly and helpful, too.) Staying here absolutely made our family visit to the Keys exceptional. Highly, highly recommend!! Will definitely stay again if we visit the Keys again!"
A verified traveler stayed at Sugarloaf Key Hotel at KOA Resort
Sugarloaf Key Hotel at KOA Resort

Types of hotels

Hotels near…

Hotels by star rating

Areas of Lower Florida Keys