
Exclusive Mississippi River Vacation Deals

Mississippi River vacation package deals
Price found within the past 48 hours. Click for updated prices.

Swissotel - Chicago
Downtown Chicago
Save 100% on your flight
Price was $367, price is now $250 per person
$250
per person
Mar 10 - Mar 12
found 1 day ago
Roundtrip flight included
New York (JFK) to Chicago (ORD)
This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, express check-in, and valet parking. A restaurant, a 24-hour front desk, and laundry facilities are also provided.

The Wildwood Hotel
Save 100% on your flight
Price was $1,283, price is now $650 per person
$650
per person
Feb 13 - Feb 19
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Latitude Apartments
Save 100% on your flight
Price was $1,070, price is now $602 per person
$602
per person
Feb 15 - Feb 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to New Orleans (MSY)
This apartment features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Self parking, a free grocery shopping service, and a grocery/convenience store are also offered.

Waldorf Astoria Chicago
Downtown Chicago
Save 100% on your flight
Price was $712, price is now $452 per person
$452
per person
Mar 10 - Mar 12
found 1 day ago
Roundtrip flight included
New York (JFK) to Chicago (ORD)
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the indoor pool and perks like a free area shuttle.

Hilton Garden Inn Chesterfield
Save 100% on your flight
Price was $1,124, price is now $746 per person
$746
per person
Feb 13 - Feb 19
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and perks like free self parking.

Economy Inn By OYO Lockport near Houma
Save 100% on your flight
Price was $588, price is now $394 per person
$394
per person
Feb 15 - Feb 21
found 1 day ago
Roundtrip flight included
New York (JFK) to New Orleans (MSY)
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage and laundry facilities are also provided.
Frequently asked questions
Top Mississippi River hotel deals

Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $117 total per night
$117 total
Dec 30 - Dec 31
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and a 24-hour front desk and a coffee shop are also provided.
Pet friendly
Free WiFi

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
333 Washington Ave St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$98 nightly
The price is $114 total per night
$114 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included

Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$95 nightly
The price is $111 total per night
$111 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the sauna and free full breakfast each morning.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Mississippi River
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Explore More Ways to Travel with Travelocity
- Farmstay in Central United States
- Chalets in Central United States
- Condo Resorts in Central United States
- Condos in Central United States
- Guest Houses in Central United States
- Adults Only Resorts & in Central United States
- All Inclusive Resorts & in Central United States
- Beach Resorts & in Central United States
- Benchmark Hotels in Central United States
- Citizenm Hotels in Central United States
- Drury Inn & Suites Hotels in Central United States
- Four Seasons Hotels in Central United States
- Hilton Hotels in Central United States
- Hotels with Early Check-in in Central United States
- Hotels with Waterslides in Central United States
- Hyatt Hotels in Central United States
- Loews Hotels in Central United States
- Pet Friendly Hotels in Central United States
- Remington Hotels in Central United States
- Ski Resorts and in Central United States
- Sonesta Hotel in Central United States
- Spa Resorts & in Central United States
- Waterpark Hotels and Resorts in Central United States
- Wyndham Hotels in Central United States
- Central United States Hotels
- Vacation Homes in Central United States
- Rv Parks in Central United States
- Apartments in Southeast Iowa
- B&B in Southeast Iowa
- Cabins in Southeast Iowa
- Condos in Southeast Iowa
- Cottages in Southeast Iowa
- Casino Resorts & in Southeast Iowa
- Kid Friendly Hotels in Southeast Iowa
- Hotels with Pools in Southeast Iowa
- Hotels with Bar in Southeast Iowa
- Hotels with Hot Tubs in Southeast Iowa
- Hotels with Waterslides in Southeast Iowa
- Luxury Hotels in Southeast Iowa
- Pet Friendly Hotels in Southeast Iowa
- Romantic Getaways & Hotels in Southeast Iowa
- Waterpark Hotels and Resorts in Southeast Iowa
- Southeast Iowa Hotels
- Lodges in Southeast Iowa
- Motels in Southeast Iowa
- Vacation Homes in Southeast Iowa
- 5 Star Hotels in Quad Cities
- Apartments in Quad Cities
- B&B in Quad Cities
- Cabins in Quad Cities
- Cottages in Quad Cities
- Extended Stay Hotels in Quad Cities
- Casino Resorts & in Quad Cities
- Cheap Hotels in Quad Cities
- Kid Friendly Hotels in Quad Cities
- Golf Resorts & in Quad Cities
- Hotels with Early Check-in in Quad Cities
- Hotels with Bar in Quad Cities
- Hotels with Hot Tubs in Quad Cities
- Hotels with an Indoor Pool in Quad Cities
- Pet Friendly Hotels in Quad Cities
- Romantic Getaways & Hotels in Quad Cities
- Spa Resorts & in Quad Cities
- Waterpark Hotels and Resorts in Quad Cities
- Quad Cities Hotels
- Houseboats in Quad Cities
- Motels in Quad Cities
- Vacation Homes in Quad Cities
- Rv Parks in Quad Cities
- Flights to Central United States
- Flights from Miami to Central United States
- Flights from Atlanta to Southeast Iowa
- Flights from Chicago to Southeast Iowa
- Flights from Portland to Southeast Iowa
- Flights from Omaha to Southeast Iowa
- Flights from Tulsa to Southeast Iowa
- Flights to Quad Cities
- Flights from Brussels to Quad Cities
- Flights from Calgary to Quad Cities
- Flights from Indianapolis to Quad Cities
- Flights from Minneapolis - St. Paul to Quad Cities
- Flights from Nashville to Quad Cities
- Flights from Atlantic City to Quad Cities
- Flights from Lincoln to Quad Cities
- Flights from Boise to Quad Cities
- Car rentals near Central United States
- Car rentals near Southeast Iowa
- Minivan Car Rentals in Southeast Iowa
- Pickup Car Rentals in Southeast Iowa
- Car rentals near Quad Cities
- Convertible Car Rentals in Quad Cities
- Luxury Car Rentals in Quad Cities
- Pickup Car Rentals in Quad Cities
- Suv Car Rentals in Quad Cities