Mission District Vacation Packages 2025/2026 from $421

Mission District flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Appellation Healdsburg

Save 100% on your flight

$421

per person

Dec 12 - Dec 14

just found

Roundtrip flight included

Seattle (SEA) to San Francisco (SFO)

A full-service spa, 2 outdoor pools, and 2 hot tubs are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the gym and perks like free self parking.

Castle Inn

Downtown San Francisco

Save 100% on your flight

$480

per person

Nov 18 - Nov 24

found 1 day ago

Roundtrip flight included

Carlsbad (CLD) to San Francisco (SFO)

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. Luggage storage, concierge services, and free newspapers are also on offer.

Bay Bridge Inn

Downtown San Francisco

Save 100% on your flight

$435

per person

Nov 18 - Nov 24

found 1 day ago

Roundtrip flight included

Carlsbad (CLD) to San Francisco (SFO)

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. There's luggage storage and multilingual staff can provide around-the-clock assistance.

1 Hotel San Francisco

Downtown San Francisco

Save 100% on your flight

$754

per person

Nov 7 - Nov 10

found 1 day ago

Roundtrip non-stop flight included

Dallas (DFW) to San Francisco (SFO)

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the in-room fitness and perks like free WiFi. There's a bar/lounge on site, and a 24-hour front desk and laundry facilities are also provided.

SureStay by Best Western San Francisco Marina District

Marina District

Save 100% on your flight

$511

per person

Nov 18 - Nov 24

found 1 day ago

Roundtrip flight included

Carlsbad (CLD) to San Francisco (SFO)

Free WiFi in public areas, express check-out, and dry cleaning are available at this hotel. Enjoy the free continental breakfast each morning. Luggage storage is provided and the front desk is staffed around-the-clock.

Top Mission District hotels deals

Holiday Inn Golden Gateway by IHG

1500 Van Ness Ave, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$140 nightly

$165 total

Oct 2 - Oct 3

Total with taxes and fees

This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a bar/lounge on site, and a 24-hour front desk and laundry facilities are also provided.

Pool

Free WiFi

Hotel Riu Plaza Fisherman's Wharf

2500 Mason St, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$167 nightly

$197 total

Oct 22 - Oct 23

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and free buffet breakfast each morning.

Pool

Breakfast included

Hilton San Francisco Financial District

750 Kearny St, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$152 nightly

$179 total

Oct 17 - Oct 18

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and WiFi in public areas. Self parking, a terrace, and limo/town car service are also offered.

Pet friendly

Restaurant

Club Quarters Hotel in San Francisco

424 Clay St, San Francisco, CA

$147 nightly

$173 total

Oct 5 - Oct 6

Total with taxes and fees

A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. A coffee shop, a terrace, and limo/town car service are also on offer.

Pet friendly

Free WiFi

Handlery Union Square Hotel

351 Geary St, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$145 nightly

$170 total

Oct 2 - Oct 3

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a sauna on site, and a 24-hour front desk and express check-out are also provided.

Pool

Pet friendly

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$229 nightly

$269 total

Oct 2 - Oct 3

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. A coffee shop, a snack bar/deli, and a grocery/convenience store are also on offer.

Pet friendly

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Mission Dolores Park

Mission Dolores Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Discover the beautiful sunsets and top-notch restaurants in this vibrant area.

Street level entry overlooking the main lobby.

San Francisco Public Library

After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the entertainment choices and notable monuments in this vibrant area.

Balmy Alley

Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Frequently asked questions

How much are vacation packages to Mission District?

Adventures are calling in Mission District, with Travelocity vacation packages starting at just $421. In addition to hotels and flights, these sensational deals are an easy way to experience every corner of the world.

Where can I get the best vacation package deals for Mission District?

For the perfect Mission District package deal, you can't go past Travelocity. Select from 400 airlines and 1,000,000 properties worldwide to create the ultimate trip — it couldn't be simpler.

Why should I book my Mission District vacation package via Travelocity?

With our Price Match Guarantee, we'll match any cheaper price you find. Add to that our 24/7 customer support and superb service and your dream vacation is closer than ever before.

Can I save on my Mission District car rental if I book it with my hotel or flight?

Definitely — and if you also add a tour to your Mission District vacation package, you'll pocket even greater savings. With a package from Travelocity, you can find things to do in the region that are perfect for you, Then, jump in your rental car and work your way through the list. Monterey Bay Aquarium is one renowned attraction to check out. It's located 85 mi from Mission District.

What is there to do in Mission District?

Mission Dolores Park and San Francisco Public Library have captivated many visitors. Tick these popular sights off your to-do list and discover what the hype is about.