Explore Mission District Spa Hotels & Wellness Resorts

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Mission District Spa Resorts & Hotels

Inn San Francisco

943 South Van Ness Avenue, San Francisco, CA

$240 nightly

$280 total

Jul 20 - Jul 21

Total includes taxes and fees

A rooftop terrace, self parking, and laundry facilities are featured at this bed & breakfast. Guests will appreciate free perks like buffet breakfast and WiFi ...

Parker Guest House San Francisco

520 Church Street, San Francisco, CA

Free Cancellation

Reserve now, pay when you stay

$189 nightly

$220 total

Jul 20 - Jul 21

Total includes taxes and fees

This bed & breakfast features free WiFi in public areas, concierge services, and self parking. Enjoy the free continental breakfast each morning. A business ...

Don't see what you're looking for?

See all available properties in Mission District

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mission District hotels essential information

Accommodation	4,764 hotels
Lowest Price	$220
Highest Price	$280
Popular hotels	Inn San Francisco, Parker Guest House San Francisco

Recent Mission District hotel reviews by fellow wanderers

Hyatt Regency San Francisco

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"My family and LOVED our stay at this beautiful hotel. It was very clean, fun, and there is so much to do in the hotel itself including workout at the best hotel gym’s I have ever seen, shop at the mini market, dine at the amazing restaurant, or relax in one of the many chairs/sofa’s/ tables scattered throughout the resort. It is also located within walking distance of EVERYTHING! The entire staff was friendly, helpful and professional. We will return for another visit prior to the end of the year and will stay at this resort once again. "

A verified traveler from Hacienda Heights stayed at Hyatt Regency San Francisco