Explore top 2025 4 Star Hotels in Southwest Houston

Name: Houston Marriott Medical Center/Museum District
Price range: $251 total
Rating: 9

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Top Southwest Houston 4 Star hotels

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd, Houston, TX

Fully refundableReserve now, pay when you stay

$123 nightly

$144 total

Oct 30 - Oct 31

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.2/10 Very Good! (2,698 reviews)

"Overall experience was good"

Reviewed on Oct 15, 2025

Hilton Houston Plaza/Medical Center

6633 Travis St, Houston, TX

Fully refundableReserve now, pay when you stay

$90 nightly

$105 total

Oct 19 - Oct 20

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...

8.2/10 Very Good! (1,638 reviews)

"The young man who checked me in was so friendly and helpful. I would stay there again just due to his kindness. The bed was a little softer than I prefer, but I still slept very well. The room was quiet and AC worked well. Good location- near museums, zoo, and hospitals."

Reviewed on Oct 14, 2025

DoubleTree by Hilton Hotel Houston - Greenway Plaza

Houston

Fully refundableReserve now, pay when you stay

$109 nightly

$128 total

Oct 19 - Oct 20

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.2/10 Very Good! (1,249 reviews)

"It was so pleasant"

Reviewed on Oct 15, 2025

Omni Houston Hotel

4 Riverway, Houston, TX

Fully refundableReserve now, pay when you stay

$194 nightly

$227 total

Nov 9 - Nov 10

Total with taxes and fees

A full-service spa, a nightclub, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (1,015 reviews)

Excellent staff but pricey

"The hotel it self is expensive, you have to pay for everything. Parking, WiFi, etc. the hotel pool service for food and drinks was closed so you have to go to the busy bar and order (and go up and down A lot of stairs) but the staff was Excellent from check in to check out."

Reviewed on Oct 12, 2025

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave, Houston, TX

Fully refundableReserve now, pay when you stay

$132 nightly

$154 total

Nov 16 - Nov 17

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,554 reviews)

"Everything was beautiful and breathtaking..I didn't want to check out..I will be back for a long time 😀. birthday was everything"

Reviewed on Oct 13, 2025

The Royal Sonesta Houston Galleria

2222 West Loop South, Houston, TX

Fully refundableReserve now, pay when you stay

$119 nightly

$139 total

Nov 16 - Nov 17

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.2/10 Very Good! (1,290 reviews)

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Reviewed on Oct 13, 2025

Hyatt Regency Houston/Galleria

2626 Sage Road, Houston, TX

Fully refundableReserve now, pay when you stay

$155 nightly

$181 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

8.8/10 Excellent! (1,098 reviews)

"Clean room Very nice hotel"

Reviewed on Oct 12, 2025

The Westin Galleria Houston

5060 W Alabama St, Houston, TX

Fully refundableReserve now, pay when you stay

$209 nightly

$245 total

Oct 24 - Oct 25

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,002 reviews)

"Loved it was INSIDE the mall, did NOT like $61.99 for valet parking per day!"

Reviewed on Oct 11, 2025

InterContinental Houston by IHG

6750 Main St, Houston, TX

Fully refundable

$152 nightly

$178 total

Oct 19 - Oct 20

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,014 reviews)

"Our room was very clean and the bed was super comfortable. The front desk was very friendly"

Reviewed on Oct 14, 2025

Houston Marriott Medical Center/Museum District

6580 Fannin Street, Houston, TX

Fully refundableReserve now, pay when you stay

$214 nightly

$251 total

Oct 19 - Oct 20

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9/10 Wonderful! (1,003 reviews)

"Property was very clean and safe was very friendly."

Reviewed on Oct 10, 2025

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4 Star Hotels Southwest Houston

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southwest Houston 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southwest Houston will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southwest Houston, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.