Explore top 2025 4 Star Hotels in Panama City

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Nov 26 to Nov 27
$121 total
Nov 26 - Nov 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.4/10 Very Good! (2,262 reviews)
The hotel room had a a/c leak and all they did was wipe it up. TV had no English channels that is unless maintenance did not know how to change it . Food prices were high

Reviewed on Nov 12, 2025

Opens in a new windowCrowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $149 total per night from Nov 23 to Nov 24
$149 total
Nov 23 - Nov 24
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.4/10 Very Good! (977 reviews)
Excelente atención y servicio La cuna de bebé era de material como fierro, insegura para bebés que ya se paran un poco El área de juegos de niños siempre mojada y no tenía protección solar podría adecuarse mejor

Reviewed on Nov 1, 2025

Opens in a new windowSheraton Grand Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $123 total per night from Dec 5 to Dec 6
$123 total
Dec 5 - Dec 6
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,196 reviews)
Thanks

Reviewed on Nov 14, 2025

Opens in a new windowMegapolis Hotel Panamá
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in ...
9/10 Wonderful! (1,000 reviews)
Hotel architecture location and friendliness’s of staff

Reviewed on Nov 2, 2025

Opens in a new windowCentral Hotel Panama Casco Viejo
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
Fully refundableReserve now, pay when you stay
$44 nightly
The price is $49 total per night from Nov 16 to Nov 17
$49 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (553 reviews)
Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here

Reviewed on Nov 1, 2025

Opens in a new windowStudio Coliving
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Nov 16 to Nov 17
$148 total
Nov 16 - Nov 17
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (1,002 reviews)
The room was clean. Staff was friendly. The breakfast was delicious. A more fragrant and less industrial-smelling shower gel would have been nice. However, that was no deal breaker for me.

Reviewed on Nov 12, 2025

Opens in a new windowMarriott Panama Hotel
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Dec 9 to Dec 10
$99 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...
9/10 Wonderful! (1,000 reviews)
My stay was nothing short of amazing, room was superb, the staff was friendly, the hotel was located in the ideal spot and I want to thank the front desk clerk Javier he really made our stay so much more awesome; he was helpful, accommodating, knowledgeable and all with a smile his service (11/10), ...

Reviewed on Nov 13, 2025

Opens in a new windowNovotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
$105 nightly
The price is $116 total per night from Nov 21 to Nov 22
$116 total
Nov 21 - Nov 22
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (1,086 reviews)
Was blown away from we walked in. The staff were extremely welcoming and helpful. Everything about this hotel was amazing. The rooms were so comfortable I did not want to leave. The level of cleanliness was next level. My favorite was the shower in our room. We will definitely book this hotel in ...

Reviewed on Nov 12, 2025

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $145 total per night from Nov 16 to Nov 17
$145 total
Nov 16 - Nov 17
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
8.8/10 Excellent! (1,000 reviews)
Yes

Reviewed on Nov 14, 2025

Opens in a new windowLas Americas Golden Tower Panama
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,394 reviews)
The room did not have towels when I arrived, I called to request them. Everything else was good.

Reviewed on Nov 3, 2025

Opens in a new windowDecapolis Hotel Panama City
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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