Explore top 2026 4 Star Hotels in Panama City

Name: American Trade Hotel
Price range: $244 total
Rating: 9.2

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

Fully refundable

$110 nightly

$121 total

Jan 8 - Jan 9

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...

8.4/10 Very Good! (2,353 reviews)

Fantastic, great staff, lovely pool for relaxing. I had a short layover and they even allowed early check in.

Reviewed on Jan 2, 2026

Megapolis Hotel Panamá

Avenida Balboa Panama City

Fully refundableReserve now, pay when you stay

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,331 reviews)

The property is centrally located and the staff is very accommodating and nice

Reviewed on Jan 1, 2026

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Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama

Fully refundableReserve now, pay when you stay

$116 nightly

$129 total

Jan 11 - Jan 12

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...

8.8/10 Excellent! (1,014 reviews)

Going location, great city views

Reviewed on Jan 4, 2026

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall Panama City Panama

$134 nightly

$147 total

Feb 6 - Feb 7

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...

9/10 Wonderful! (1,005 reviews)

Great property, service and location.

Reviewed on Dec 31, 2025

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons Panama City Panama

Fully refundableReserve now, pay when you stay

$111 nightly

$122 total

Jan 14 - Jan 15

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...

9/10 Wonderful! (1,055 reviews)

Muy cerca del metro perfecto para un stopover

Reviewed on Dec 31, 2025

Studio Coliving

Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

7.8/10 Good! (585 reviews)

Staff very helpful

Reviewed on Dec 11, 2025

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Decapolis Hotel Panama City

Avenida Balboa Con Multicentro Panama City Panama

Fully refundableReserve now, pay when you stay

$108 nightly

$119 total

Jan 28 - Jan 29

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,481 reviews)

Excellent room for my family

Reviewed on Jan 5, 2026

Ramada Plaza by Wyndham Panama Punta Pacifica

Via Israel y Calle 71, San Francisco Panama City Panama

Fully refundableReserve now, pay when you stay

$111 nightly

$122 total

Jan 14 - Jan 15

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9.4/10 Exceptional! (1,137 reviews)

Breakfast buffet was terrific, lots of choices, lots of staff to keep it clean. Clean, quiet, comfy beds, nice room and terric shower. Great front desk staff as well!

Reviewed on Jan 3, 2026

American Trade Hotel

Plaza Herrera Casco Viejo Panama City Panama

$219 nightly

$244 total

Jan 11 - Jan 12

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.2/10 Wonderful! (619 reviews)

We had a wonderful stay at the American Trade Hotel in Panama City. The hotel is a beautifully preserved historic landmark, and you feel that character the moment you walk in. The unique floor tiles and thoughtful design details give it a charm you do not find in typical hotels, and everything was ...

Reviewed on Dec 31, 2025

Sheraton Grand Panama

Via Israel And 77th Street Panama City Panama

Fully refundableReserve now, pay when you stay

$137 nightly

$150 total

Jan 14 - Jan 15

Total with taxes and fees

A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...

8.4/10 Very Good! (1,003 reviews)

The breakfast had a variety of foods to choose from and house keeping is everyday

Reviewed on Dec 30, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.