Explore top 2026 4 Star Hotels in Panama City

Name: American Trade Hotel
Price range: $252 total
Rating: 9.2

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Top Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

Fully refundable

$121 nightly

$133 total

Feb 12 - Feb 13

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...

8.4/10 Very Good! (2,421 reviews)

Perfect for PTY airport travelers, easy shuttle to and from airport. Fast check in and check out. Restaurant right in the hotel.

Reviewed on Feb 6, 2026

Megapolis Hotel Panamá

Avenida Balboa Panama City

Fully refundableReserve now, pay when you stay

$231 nightly

$254 total

Feb 15 - Feb 16

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,407 reviews)

All awesome.

Reviewed on Feb 5, 2026

Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama

Fully refundableReserve now, pay when you stay

$175 nightly

$194 total

Feb 25 - Feb 26

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

8.8/10 Excellent! (1,018 reviews)

Good value for the money

Reviewed on Feb 8, 2026

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall Panama City Panama

Fully refundableReserve now, pay when you stay

$161 nightly

$177 total

Mar 7 - Mar 8

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...

9/10 Wonderful! (1,015 reviews)

Good room, good breakfast, friendly staff

Reviewed on Feb 6, 2026

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons Panama City Panama

Fully refundableReserve now, pay when you stay

$121 nightly

$133 total

Mar 3 - Mar 4

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. There's fun for all ages with a free kid's club and a playground, and families will appreciate ...

9/10 Wonderful! (1,092 reviews)

Room was nice

Reviewed on Feb 6, 2026

Studio Coliving

Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

7.8/10 Good! (588 reviews)

Staff very helpful

Reviewed on Dec 11, 2025

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Decapolis Hotel Panama City

Avenida Balboa Con Multicentro Panama City Panama

Fully refundableReserve now, pay when you stay

$113 nightly

$125 total

Feb 27 - Feb 28

Total with taxes and fees

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,535 reviews)

Great staff , clean overall everything great , the only thing we check out a day early do to the weather in USA.

Reviewed on Feb 3, 2026

Ramada Plaza by Wyndham Panama Punta Pacifica

Via Israel y Calle 71, San Francisco Panama City Panama

Fully refundableReserve now, pay when you stay

$98 nightly

$108 total

Feb 27 - Feb 28

Total with taxes and fees

This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

9.4/10 Exceptional! (1,154 reviews)

The staff were all top notch, friendly, helpful, the list goes on.The cleanliness of the hotel was superior, our room was a nice size and beds very comfortable. The breakfast was enjoyable, with a change of some things on the menu each day. Our 24 nights there went fast, we enjoyed our stay, Thank ...

Reviewed on Feb 1, 2026

American Trade Hotel

Plaza Herrera Casco Viejo Panama City Panama

Fully refundableReserve now, pay when you stay

$227 nightly

$252 total

Feb 17 - Feb 18

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.2/10 Wonderful! (657 reviews)

Staff was excellent from every transaction we had with them. Very friendly and helpful. Only stayed 2 days yet the staff knew us and greeted us when we saw them. The room was great. A little cold but they helped us regulate the temperature.

Reviewed on Feb 1, 2026

Sheraton Grand Panama

Via Israel And 77th Street Panama City Panama

Fully refundableReserve now, pay when you stay

$134 nightly

$148 total

Feb 20 - Feb 21

Total with taxes and fees

A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...

8.4/10 Very Good! (1,003 reviews)

Great staff

Reviewed on Jan 15, 2026

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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.