$184 Cheap American Airlines flights from Detroit to Knoxville (DTW to TYS)

Find The Best Day To Fly from Detroit to Knoxville

Amazing American Airlines DTW to TYS Flight Deals

The cheapest flights to McGhee Tyson found within the past 7 days were $307 round trip and $184 one way. Prices and availability subject to change. Additional terms may apply.

Sat, Oct 4 - Sun, Oct 5
DTW
Detroit
TYS
Knoxville
$307 Roundtrip, found 4 days ago
$307
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 4 from Detroit to Knoxville, returning Sun, Oct 5, priced at $307 found 4 days ago
Thu, Oct 2 - Mon, Oct 6
DTW
Detroit
TYS
Knoxville
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 2 from Detroit to Knoxville, returning Mon, Oct 6, priced at $310 found 4 days ago
Sat, Oct 4 - Sun, Oct 5
DTW
Detroit
TYS
Knoxville
$324 Roundtrip, found 4 days ago
$324
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 4 from Detroit to Knoxville, returning Sun, Oct 5, priced at $324 found 4 days ago
Thu, Oct 2 - Mon, Oct 6
DTW
Detroit
TYS
Knoxville
$327 Roundtrip, found 4 days ago
$327
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 2 from Detroit to Knoxville, returning Mon, Oct 6, priced at $327 found 4 days ago
Thu, Aug 14 - Sat, Aug 16
DTW
Detroit
TYS
Knoxville
$334 Roundtrip, found 2 days ago
$334
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Aug 14 from Detroit to Knoxville, returning Sat, Aug 16, priced at $334 found 2 days ago
Thu, Oct 2 - Mon, Oct 6
DTW
Detroit
TYS
Knoxville
$340 Roundtrip, found 4 days ago
$340
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 2 from Detroit to Knoxville, returning Mon, Oct 6, priced at $340 found 4 days ago

TYS From DTW Economy Coach Packages on Similar Airlines

Price found within the past 48 hours. Click for updated prices.
Sunrise Ridge Resort

Sunrise Ridge Resort

3 out of 5
per person
Aug 13 - Aug 17
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Knoxville (TYS)
Westgate Smoky Mountain Resort & Water Park

Westgate Smoky Mountain Resort & Water Park

4 out of 5
per person
Aug 13 - Aug 17
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Knoxville (TYS)
Compass Hotel by Margaritaville

Compass Hotel by Margaritaville

3 out of 5
per person
Aug 13 - Aug 17
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Knoxville (TYS)
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Travelers ❤️ these 🏨 after their flight to Knoxville

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy, Alcoa, TN
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,011 reviews)
"Great location to the airport and fantastic staff!"

Reviewed on Jul 15, 2025

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road, Alcoa, TN
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8.8/10 Excellent! (1,476 reviews)
"Loved this place!"

Reviewed on Jul 17, 2025

La Quinta Inn & Suites by Wyndham Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd, Alcoa, TN
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
8.4/10 Very Good! (1,014 reviews)
"Very clean"

Reviewed on Jul 16, 2025

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.