Explore 28 Luxury Hotels in Southeastern Indiana

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Southeastern Indiana

21c Museum Hotel Louisville

21c Museum Hotel Louisville

700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $178 total per night from Jan 27 to Jan 28
$178 total
Jan 27 - Jan 28
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,000 reviews)
Staff very helpful. Rooms are spacious and clean. Lobby exhibits unique and interesting. Hotel well situated in downtown to access popular tourist attractions. Enjoyed our stay.

Reviewed on Jan 20, 2026

Opens in a new window21c Museum Hotel Louisville
The Brown Hotel

The Brown Hotel

335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $198 total per night from Jan 28 to Jan 29
$198 total
Jan 28 - Jan 29
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,174 reviews)
Nice historic hotel. Rooms are a bit tired.

Reviewed on Jan 22, 2026

Opens in a new windowThe Brown Hotel
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from Jan 29 to Jan 30
$161 total
Jan 29 - Jan 30
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,999 reviews)
The breakfast was delicious, the staff was amazing to be with and supper attended.

Reviewed on Jan 20, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $148 total per night from Feb 1 to Feb 2
$148 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
8.8/10 Excellent! (1,144 reviews)
Room was spotless

Reviewed on Jan 23, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Feb 1 to Feb 2
$155 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
8.6/10 Excellent! (1,000 reviews)
The area was congested but the motel was good.

Reviewed on Jan 14, 2026

Opens in a new windowSeelbach Hilton Louisville Downtown
Baymont by Wyndham Corydon

Baymont by Wyndham Corydon

2495 Landmark Avenue NE Corydon IN
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $75 total per night from Feb 8 to Feb 9
$75 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...
7.4/10 Good! (999 reviews)
Very good choice for a road trip break. Especially if you have pets. Appreciated the conveniences of the area, multiple food choices and a Walmart. Gas was a little less than other nearby Hwy 64 exits. Breakfast had waffles, eggs, and sausage plus continental choices. Camera on parking lot made you ...

Reviewed on Jan 4, 2026

Opens in a new windowBaymont by Wyndham Corydon
Econo Lodge Louisville Downtown

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $74 total per night from Feb 8 to Feb 9
$74 total
Feb 8 - Feb 9
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...
7/10 Good! (1,000 reviews)
Nice hotel with a great location near Whiskey Row. This is my 3rd stay at this hotel and will definitely come back again

Reviewed on Dec 11, 2025

Opens in a new windowEcono Lodge Louisville Downtown
West Baden Springs Hotel

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN
This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...
The hotel West Baden is awesome they have 24 hour trolley that runs every 15 minutes and will take you anywhere in the area.

Reviewed on Dec 25, 2018

Opens in a new windowWest Baden Springs Hotel
Don't see what you're looking for?
See all available properties in Southeastern Indiana
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southeastern Indiana

Southeastern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeastern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southeastern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southeastern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeastern Indiana, and plan your next opulent escape.


Southeastern Indiana hotels essential information

Accommodation
1,172 hotels
Lowest Price
$74
Highest Price
$216
Popular hotels
21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon

Popular Luxury Stays in Southeastern Indiana

Recent Southeastern Indiana Hotel Reviews By Fellow Wanderers

Explore More Ways to Travel with Travelocity