Explore 28 Luxury Hotels in Southeastern Indiana

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Best Luxury Hotels in Southeastern Indiana

21c Museum Hotel Louisville

21c Museum Hotel Louisville

700 W Main Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $205 total per night from May 26 to May 27
$205 total
May 26 - May 27
Total includes taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,001 reviews)
"Very comfortable bed and great shower. Quiet room. Terrific location walking distance to many places downtown. Would be a five star but for absence of good workspace in room (no desk). Not an issue for non-business travel, but if you need to work in the room, there is not a good comfortable place ..."

Reviewed on Apr 28, 2025

21c Museum Hotel Louisville
The Brown Hotel

The Brown Hotel

335 W Broadway, Louisville, KY
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $211 total per night from May 25 to May 26
$211 total
May 25 - May 26
Total includes taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,003 reviews)
A Concierge on a Mission.
"Our stay at The Brown Hotel did not disappoint! While Louisville let us down a bit with a closed Museum in the Historic District we were wanting to see, the crazy cost of downtown parking and lack of activities during the week, our hotel Concierge, Curtis made up for it with his helpful suggestions, ..."

Reviewed on May 8, 2025

The Brown Hotel
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $187 total per night from May 23 to May 24
$187 total
May 23 - May 24
Total includes taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,336 reviews)
"This my my second graduation at the KFC Yum Center in 7 years. Each time has been the best experience and looking forward too the next time."

Reviewed on May 10, 2025

Galt House Hotel Trademark Collection by Wyndham
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Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

501 South Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $139 total per night from May 25 to May 26
$139 total
May 25 - May 26
Total includes taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and WiFi in public areas. Valet ...
8.8/10 Excellent! (1,005 reviews)
"Service was good, room was clean and breakfast was great!"

Reviewed on May 10, 2025

Embassy Suites Louisville Downtown
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

500 S 4th St, Louisville, KY
Fully refundableReserve now, pay when you stay
$140 nightly
The price is $165 total per night from May 25 to May 26
$165 total
May 25 - May 26
Total includes taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
8.6/10 Excellent! (1,002 reviews)
"Great hotel"

Reviewed on May 9, 2025

Seelbach Hilton Louisville Downtown
Baymont by Wyndham Corydon

Baymont by Wyndham Corydon

2495 Landmark Avenue NE, Corydon, IN
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $75 total per night from May 27 to May 28
$75 total
May 27 - May 28
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...
7.4/10 Good! (1,000 reviews)
"Great stay"

Reviewed on Apr 19, 2025

Baymont by Wyndham Corydon
Econo Lodge Downtown Louisville

Econo Lodge Downtown Louisville

401 S 2nd St, Louisville, KY
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $74 total per night from Jun 3 to Jun 4
$74 total
Jun 3 - Jun 4
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...
7.2/10 Good! (1,004 reviews)
"Great stay"

Reviewed on May 7, 2025

Econo Lodge Downtown Louisville
West Baden Springs Hotel

West Baden Springs Hotel

8538 W Baden Ave, West Baden Springs, IN
This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...
"The hotel West Baden is awesome they have 24 hour trolley that runs every 15 minutes and will take you anywhere in the area."

Reviewed on Dec 25, 2018

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West Baden Springs Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southeastern Indiana

Stellar Suites

Stellar Suites

822 E Market St, Louisville, KY
$161 nightly
The price is $187 total per night from May 26 to May 27
$187 total
May 26 - May 27
Total includes taxes and fees
9.6/10 Exceptional! (94 reviews)

Southeastern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeastern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southeastern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southeastern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeastern Indiana, and plan your next opulent escape.


Southeastern Indiana hotels essential information

Accommodation
1,035 hotels
Lowest Price
$74 total
Highest Price
$216 total
Popular hotels
21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Downtown Louisville, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon

Popular Luxury Stays in Southeastern Indiana

5 Stars Luxury stays in Southeastern Indiana

Hotels 5 Stars

Hotels 5 Stars
Luxury stays in Southeastern Indiana with spa

Hotels with Spa

Hotels with Spa

Popular places to visit

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

You can spend an afternoon browsing the exhibits at Louisville Slugger Museum during your travels in Louisville. Amble around the area's riverfront or attend a sporting event.

See properties in Louisville Slugger Museum
Louisville Slugger Museum

Seize your some day

Recent Southeastern Indiana Hotel Reviews By Fellow Wanderers

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

5 out of 5
Posted 7 days ago
Travelocity Verified Review
"The location is next to the interstate, making it easy to get back and forth to Louisville. We did go down late for breakfast the first morning and they were out of pretty much everything, including coffee and the front desk attendent was on his phone and not empathetic about the situatuon"
A verified traveler stayed at Hampton Inn New Albany Louisville West
Hampton Inn New Albany Louisville West
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