Explore 18 Luxury Hotels in South San Francisco

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Best Luxury Hotels in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

250 Gateway Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Oct 31 to Nov 1
$172 total
Oct 31 - Nov 1
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.4/10 Very Good! (1,203 reviews)
Rec

Reviewed on Oct 18, 2025

Opens in a new windowEmbassy Suites by Hilton San Francisco Airport Oyster Point
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

670 Gateway Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $119 total per night from Nov 9 to Nov 10
$119 total
Nov 9 - Nov 10
Total with taxes and fees
A restaurant and a gym are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.4/10 Very Good! (1,001 reviews)
Close to airport, great room, reasonable price

Reviewed on Oct 16, 2025

Opens in a new windowHilton Garden Inn San Francisco Arpt North
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

20 Airport Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $119 total per night from Nov 2 to Nov 3
$119 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8/10 Very Good! (2,023 reviews)
The staff at check in and check out were VERY friendly!! I appreciated that it was close to the airport and a Denny’s for lunch!!

Reviewed on Oct 22, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Francisco Airport N
Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North

121 E Grand Ave, South San Francisco, CA
$92 nightly
The price is $108 total per night from Oct 26 to Oct 27
$108 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free airport pick-up. Business travelers can take advantage of the ...
7.6/10 Good! (1,002 reviews)
Exelent especially those filipina front desk really good customer services keep up the good work.

Reviewed on Oct 17, 2025

Opens in a new windowComfort Inn and Suites San Francisco Airport North
Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco

690 Gateway Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $104 total per night from Nov 8 to Nov 9
$104 total
Nov 8 - Nov 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling for business? Take advantage of the business center, laundry service, ...
7.6/10 Good! (1,000 reviews)
Bedding was not comfortable mattress was to hard other then that hotel was decent.

Reviewed on Oct 7, 2025

Opens in a new windowLarkspur Landing Extended Stay Suites South San Francisco
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Nov 14 to Nov 15
$105 total
Nov 14 - Nov 15
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and self parking. Enjoy freebies like on-the-go breakfast and a roundtrip airport shuttle ...
7.4/10 Good! (1,471 reviews)
Nice staff

Reviewed on Oct 23, 2025

Opens in a new windowHotel Focus SFO
Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

326 S Airport Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $73 total per night from Nov 24 to Nov 25
$73 total
Nov 24 - Nov 25
Total with taxes and fees
A restaurant and an outdoor pool are featured at this motel. Traveling on business? Take advantage of the free WiFi in public areas, conference space, and free ...
5.8/10 (2,695 reviews)
Yes

Reviewed on Oct 17, 2025

Opens in a new windowTravelodge by Wyndham San Francisco Airport North
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $91 total per night from Oct 26 to Oct 27
$91 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A lobby fireplace, a picnic area, and luggage storage are also on ...
5.6/10 (1,027 reviews)
The best

Reviewed on Oct 17, 2025

Opens in a new windowPark Pointe Hotel
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More 4 star hotels in South San Francisco

5 star hotels in South San Francisco

South San Francisco Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South San Francisco luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South San Francisco to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South San Francisco will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South San Francisco, and plan your next opulent escape.


South San Francisco hotels essential information

Accommodation
5,032 hotels
Lowest Price
$73
Highest Price
$465
Popular hotels
Travelodge by Wyndham San Francisco Airport North, Hotel Focus SFO, Comfort Inn and Suites San Francisco Airport North, Embassy Suites by Hilton San Francisco Airport Oyster Point, Hilton Garden Inn San Francisco Arpt North, Larkspur Landing Extended Stay Suites South San Francisco, Park Pointe Hotel, La Quinta Inn & Suites by Wyndham San Francisco Airport N

Popular Luxury Stays in South San Francisco

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