Explore 18 Luxury Hotels in South San Francisco

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Best Luxury Hotels in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

250 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Jan 31 to Feb 1
$172 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.4/10 Very Good! (1,274 reviews)
Stayed in the corner suite. It did need some updating but it was spacious and the beds were super comfortable. Didn’t want to get up lol and almost stayed another night because the beds were so comfy. The breakfast was so good! So many options. Liked the conference table in the room and all of the ...

Reviewed on Jan 23, 2026

Opens in a new windowEmbassy Suites by Hilton San Francisco Airport Oyster Point
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

670 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $115 total per night from Jan 31 to Feb 1
$115 total
Jan 31 - Feb 1
Total with taxes and fees
A restaurant and a gym are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.4/10 Very Good! (1,000 reviews)
Room was clean and comfortable. Staff was courteous.

Reviewed on Jan 16, 2026

Opens in a new windowHilton Garden Inn San Francisco Arpt North
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

20 Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $119 total per night from Jan 30 to Jan 31
$119 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8/10 Very Good! (2,015 reviews)
Nice Clean hotel

Reviewed on Jan 19, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Francisco Airport N
Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North

121 E Grand Ave South San Francisco CA
$101 nightly
The price is $118 total per night from Jan 31 to Feb 1
$118 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free airport pick-up. Business travelers can take advantage of the ...
7.6/10 Good! (999 reviews)
Hotel is rather old but very clean and comfortable. Staff was very friendly. Fitness area could use some work - treadmill didn’t work at all.

Reviewed on Jan 16, 2026

Opens in a new windowComfort Inn and Suites San Francisco Airport North
Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco

690 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $118 total per night from Jan 31 to Feb 1
$118 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the business center and onsite conference ...
7.6/10 Good! (1,000 reviews)
As it is the least expensive hotel in the area, manage expectations and be flexible. It was a good value, excellent staff and close to where I needed to be. The front desk staff was great every interaction. Decor is dated but reasonably good condition. One bedroom suite was a good size. The living ...

Reviewed on Jan 14, 2026

Opens in a new windowLarkspur Landing Extended Stay Suites South San Francisco
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave South San Francisco CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Feb 15 to Feb 16
$105 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and self parking. Enjoy freebies like on-the-go breakfast and a roundtrip airport shuttle ...
7.4/10 Good! (1,532 reviews)
Clean room

Reviewed on Jan 20, 2026

Opens in a new windowHotel Focus SFO
Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

326 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $73 total per night from Jan 30 to Jan 31
$73 total
Jan 30 - Jan 31
Total with taxes and fees
A restaurant and an outdoor pool are featured at this motel. Traveling on business? Take advantage of the free WiFi in public areas, conference space, and free ...
5.8/10 (3,086 reviews)
I use the airport shuttle, it was convenient, frequency should could be more, the room was clean and basic and Price was nice. Thank you for a wonderful experience.

Reviewed on Jan 22, 2026

Opens in a new windowTravelodge by Wyndham San Francisco Airport North
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $83 total per night from Jan 26 to Jan 27
$83 total
Jan 26 - Jan 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A lobby fireplace, a picnic area, and luggage storage are also on ...
5.8/10 (1,000 reviews)
Room was ok for 2 people. Don’t bother to use the phone in the room, it doesn’t work. It does not have a phone line plugged into the unit hence, the phone is useless.

Reviewed on Dec 19, 2025

Opens in a new windowPark Pointe Hotel
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More 4 star hotels in South San Francisco

5 star hotels in South San Francisco

South San Francisco Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South San Francisco luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South San Francisco to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South San Francisco will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South San Francisco, and plan your next opulent escape.


South San Francisco hotels essential information

Accommodation
5,176 hotels
Lowest Price
$73
Highest Price
$527
Popular hotels
Travelodge by Wyndham San Francisco Airport North, Hotel Focus SFO, Comfort Inn and Suites San Francisco Airport North, Embassy Suites by Hilton San Francisco Airport Oyster Point, Hilton Garden Inn San Francisco Arpt North, Larkspur Landing Extended Stay Suites South San Francisco, Park Pointe Hotel, La Quinta Inn & Suites by Wyndham San Francisco Airport N

Popular Luxury Stays in South San Francisco

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