Eastern Panama Vacation Packages 2025/2026 from $750

Eastern Panama flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

Bella Vista

per person

Sep 20 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Sep 20 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Central Hotel Bocas del Toro

Save 100% on your flight

per person

Sep 4 - Sep 9

found 21 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

A marina and a restaurant are featured at this hotel. Enjoy the outdoor pool and free perks like continental breakfast and WiFi in public areas. A bar/lounge, a 24-hour front desk, and dry cleaning are also provided.

Waldorf Astoria Panama

Bella Vista

Save 100% on your flight

per person

Sep 20 - Sep 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly dining, and babysitting. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free WiFi.

The Sands by Wynwood House

Calidonia

Save 100% on your flight

per person

Aug 25 - Aug 29

found 12 hours ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

An outdoor pool is available at this apartment.

Top Eastern Panama hotels deals

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

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This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like full breakfast and free self parking.

On private beach

Pool

Private Over the Water Cabin on San Blas Island

9.542876, -78.899058, Narganá, San Blas

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This cabin features a restaurant, a coffee shop, and a terrace. Enjoy the free local cuisine breakfast each morning. A garden and a snack bar/deli are also provided.

Breakfast included

Kitchen

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

$140 nightly

$153 total

Jul 23 - Jul 24

Total includes taxes and fees

A restaurant and an outdoor pool are featured at this hotel. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A garden and a virtual front desk are also provided.

Pool

Breakfast included

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

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This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

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A full-service spa, 3 restaurants, and 4 outdoor pools are all featured at this smoke-free hotel. Relax with a drink at the beach bar and enjoy free perks like cooked-to-order breakfast and valet parking. A business center, free WiFi in public areas, and a terrace are also on offer.

Pool

Breakfast included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

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Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as $750. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.