Find a Hotel in South Central Houston

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Top hotels in South Central Houston

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$241 nightly
The price is $282 total per night from Jul 8 to Jul 9
$282 total
Jul 8 - Jul 9
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
"This hotel is marketed as upscale and luxurious, but my experience was quite the opposite. After arriving late in the evening, around 11:45 PM, I was disappointed to find a room that felt extremely dated and in need of significant renovation. The furnishings and overall condition of the room gave ..."

Reviewed on Jun 21, 2026

Opens in a new windowHotel Zaza Houston Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
$164 nightly
The price is $192 total per night from Jul 26 to Jul 27
$192 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"The breakfast could be extended a little more, but I understand that they were on a special occasion but they do not make the guests feel welcome. I didn't like the treatment yesterday in the middle of the event they had, especially one of the managers who didn't allow us to get on the advisor and ..."

Reviewed on Jun 24, 2026

Opens in a new windowInterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $178 total per night from Jul 5 to Jul 6
$178 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Clean, modern room. Helpful and available staff. A+++"

Reviewed on Jun 25, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $104 total per night from Jul 6 to Jul 7
$104 total
Jul 6 - Jul 7
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like self-serve breakfast and WiFi in ...
"We stayed here for one night for a concert at the Toyota Center. The room was a little musty (smelled like a former smoking room but nothing recent) but the location was very convenient and staff were extremely nice and accommodating. Not bad for the price and felt safe and comfortable. Mattress ..."

Reviewed on Jun 26, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $199 total per night from Jul 24 to Jul 25
$199 total
Jul 24 - Jul 25
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"Thank you . All very good."

Reviewed on Jun 25, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Sentral Forme Houston

Sentral Forme Houston

4.5 out of 5
5501 La Branch Street Houston TX
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $227 total per night from Jul 7 to Jul 8
$227 total
Jul 7 - Jul 8
Total with taxes and fees
This aparthotel features an outdoor pool and a 24-hour gym. Enjoy the hot tub and perks like free WiFi. Self parking and express check-in are also offered on ...
"This is not a typical hotel—it's a mixed-use building that includes apartments, hotel rooms, and shared office space. I think this should be disclosed more clearly before booking. That said, the building itself is very nice, modern, and exceptionally clean. The room was beautiful, and the city views ..."

Reviewed on Jun 25, 2026

Opens in a new windowSentral Forme Houston
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Jul 5 to Jul 6
$117 total
Jul 5 - Jul 6
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Everything was good. Nice staff."

Reviewed on Jun 26, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Jul 5 to Jul 6
$143 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The service was great. The hotel was very clean."

Reviewed on Jun 25, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $100 total per night from Jul 8 to Jul 9
$100 total
Jul 8 - Jul 9
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Guests will ...
"Very good for the price. We only stayed one night but the staff was fantastic!"

Reviewed on Jun 25, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Central Houston Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Central Houston area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Central Houston to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Central Houston are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Central Houston hotel reviews by fellow wanderers

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