Explore top 2026 5 Star Hotels in Panama Canal Zone

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$121 nightly
The price is $133 total per night from Mar 8 to Mar 9
$133 total
Mar 8 - Mar 9
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,990 reviews)
The room was very nice

Reviewed on Feb 20, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
$221 nightly
The price is $243 total per night from Mar 7 to Mar 8
$243 total
Mar 7 - Mar 8
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,003 reviews)
Staff were excellent, room was clean, pool area was great.

Reviewed on Feb 19, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
$183 nightly
The price is $202 total per night from Mar 7 to Mar 8
$202 total
Mar 7 - Mar 8
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,001 reviews)
They were great

Reviewed on Feb 18, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
$299 nightly
The price is $329 total per night from Mar 22 to Mar 23
$329 total
Mar 22 - Mar 23
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,010 reviews)
Great stay

Reviewed on Feb 20, 2026

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
$378 nightly
The price is $416 total per night from Feb 24 to Feb 25
$416 total
Feb 24 - Feb 25
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (597 reviews)
The hotel was gorgeous - timeless, classy and well appointed. The only disappointment was at the speak easy where I ordered a cocktail and was brought a Taro card. As a Christ follower - it was offensive to me. I asked the waiter to take it back.

Reviewed on Feb 18, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
$220 nightly
The price is $242 total per night from Mar 2 to Mar 3
$242 total
Mar 2 - Mar 3
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,006 reviews)
Great breakfast, nice pool but could use more seats. Pretty good location - can take an Uber to most places. Helpful concierge.

Reviewed on Feb 16, 2026

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
$237 nightly
The price is $260 total per night from Mar 6 to Mar 7
$260 total
Mar 6 - Mar 7
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,010 reviews)
Room services

Reviewed on Feb 19, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
$135 nightly
The price is $149 total per night from Feb 26 to Feb 27
$149 total
Feb 26 - Feb 27
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (154 reviews)
My family and I stayed at Renaissance Panama City Hotel expecting a safe and enjoyable vacation. Unfortunately, our experience was extremely disappointing. While we were away at breakfast, huge amount of money was stolen from my brother’s pants inside our room. We immediately reported the incident ...

Reviewed on Feb 19, 2026

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
$204 nightly
The price is $224 total per night from Mar 20 to Mar 21
$224 total
Mar 20 - Mar 21
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,003 reviews)
Great service

Reviewed on Feb 19, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
$269 nightly
The price is $296 total per night from Mar 7 to Mar 8
$296 total
Mar 7 - Mar 8
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (665 reviews)
It was my first time staying at the hotel and it was wonderful!! The check in was great and the staff I ran into the two days I stayed were great and very kind

Reviewed on Feb 9, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama Canal Zone hotel reviews by fellow wanderers