Explore top 2026 5 Star Hotels in Panama Canal Zone

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: $247 total
Rating: 9.6

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$122 nightly

$135 total

Jan 18 - Jan 19

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (4,766 reviews)

The room was very nice and clean

Reviewed on Jan 2, 2026

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

$221 nightly

$243 total

Jan 30 - Jan 31

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...

8.8/10 Excellent! (1,004 reviews)

Most helpful staff. Close to restaurants, ocean walk and groceries

Reviewed on Dec 31, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

$199 nightly

$219 total

Jan 30 - Jan 31

Total with taxes and fees

This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...

8.8/10 Excellent! (1,002 reviews)

Beautiful room, super clean, and friendly staff!!!

Reviewed on Jan 1, 2026

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

$299 nightly

$329 total

Jan 30 - Jan 31

Total with taxes and fees

This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.8/10 Excellent! (1,006 reviews)

Nice staff probably one of the best hotel I’ve been to.

Reviewed on Dec 31, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

$319 nightly

$351 total

Feb 1 - Feb 2

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.8/10 Exceptional! (568 reviews)

The decor was beautiful, very clean and pleasant fragrance inside. Food was great too. The very best thing was the helpful, friendly and attentive staff. Everyone, front desk, butlers, concierge, wait staff, room staff, doormen and drivers, all made us feel well taken care of and treated us like ...

Reviewed on Dec 26, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

$201 nightly

$222 total

Jan 9 - Jan 10

Total with taxes and fees

This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...

8.8/10 Excellent! (1,008 reviews)

Safe area

Reviewed on Jan 2, 2026

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

$254 nightly

$280 total

Jan 25 - Jan 26

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...

8/10 Very Good! (1,001 reviews)

The view was fantastic! The pool was very relaxing and the food was great.

Reviewed on Dec 24, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

$110 nightly

$121 total

Jan 9 - Jan 10

Total with taxes and fees

A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...

8.8/10 Excellent! (108 reviews)

Great!

Reviewed on Jan 1, 2026

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

$201 nightly

$221 total

Jan 14 - Jan 15

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,012 reviews)

Courteous staff, wonderful breakfast and a peaceful stay.

Reviewed on Jan 1, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

Fully refundableReserve now, pay when you stay

$224 nightly

$247 total

Jan 25 - Jan 26

Total with taxes and fees

This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9.6/10 Exceptional! (644 reviews)

this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.