Explore top 2026 5 Star Hotels in Panama Canal Zone

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 31 to Jun 1
$151 total
May 31 - Jun 1
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,455 reviews)
"There is no weekend entertainment at this hotel,you only see the staff at the front desk. No one even call your room to ask how your experiences. Limited English language especially house keeping, room service. The staff at the front of the building are very helpful with transportation and understand ..."

Reviewed on May 21, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $280 total per night from Jun 19 to Jun 20
$280 total
Jun 19 - Jun 20
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,001 reviews)
"Excelentes instalaciones y el personal es increíble de lo amable y con ganas de satisfacer tus deseos"

Reviewed on May 18, 2026

Opens in a new windowWaldorf Astoria Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$297 nightly
The price is $327 total per night from Jun 1 to Jun 2
$327 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (654 reviews)
"Easily one the best hotel stays ever. Great property. Great food. Excellent service."

Reviewed on May 14, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $290 total per night from Jun 6 to Jun 7
$290 total
Jun 6 - Jun 7
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,000 reviews)
"Clean rooms and common areas"

Reviewed on May 20, 2026

Opens in a new windowJW Marriott Panama
Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Calle 52 and Ricardo Arias Panama City Panamá Province
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $190 total per night from Jun 19 to Jun 20
$190 total
Jun 19 - Jun 20
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.6/10 Exceptional! (310 reviews)
"Great price on a suite!"

Reviewed on May 20, 2026

Opens in a new windowHyatt Regency Panama City
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $274 total per night from May 24 to May 25
$274 total
May 24 - May 25
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,002 reviews)
"We booked the Supreme Room and it was amazing! It had a great view and was very spacious. Upon arrival, the staff was so nice and helpful. They provided us with suggestions on where to go to eat, party and sightsee. They were always available if we had questions too. The location was close to everything ..."

Reviewed on May 4, 2026

Opens in a new windowW Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $212 total per night from Jun 7 to Jun 8
$212 total
Jun 7 - Jun 8
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,001 reviews)
"Friendly staff,great accomadations . Very relaxing. I will go back."

Reviewed on May 7, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $252 total per night from Jun 7 to Jun 8
$252 total
Jun 7 - Jun 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
9/10 Wonderful! (1,007 reviews)
"Very helpful and responsive staff. Quality across the board"

Reviewed on May 20, 2026

Opens in a new windowHilton Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$232 nightly
The price is $255 total per night from Jun 5 to Jun 6
$255 total
Jun 5 - Jun 6
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (694 reviews)
"Perfect"

Reviewed on May 8, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from May 30 to May 31
$140 total
May 30 - May 31
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (216 reviews)
"Breakfast was very good, staff are very helpful and friendly"

Reviewed on May 11, 2026

Opens in a new windowRenaissance Panama City Hotel
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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama Canal Zone hotel reviews by fellow wanderers