Explore top 2025 5 Star Hotels in Panama Canal Zone
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Panama Canal Zone 5 Star hotels
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $116 total per night from Sep 28 to Sep 29
$116 total
Sep 28 - Sep 29
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,314 reviews)
"The hotel facilities are really quite good. The rooms are spacious and well laid out. Breakfast offers a wide variety of options. Our time spent at the Restaurant and Main Bar in the lobby was also enjoyable. We had an issue with our initial room that took longer than expected to resolve, but once ..."
Reviewed on Sep 23, 2025
Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $247 total per night from Oct 11 to Oct 12
$247 total
Oct 11 - Oct 12
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,005 reviews)
"Microwave in the room"
Reviewed on Sep 21, 2025
JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $252 total per night from Oct 10 to Oct 11
$252 total
Oct 10 - Oct 11
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,012 reviews)
"Worth the price and the Hype"
Reviewed on Sep 19, 2025
The Westin Playa Bonita Panama
Km 6 Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $173 total per night from Oct 6 to Oct 7
$173 total
Oct 6 - Oct 7
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,003 reviews)
"Loved the beach"
Reviewed on Sep 5, 2025
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe, Panama City, Panama
Fully refundableReserve now, pay when you stay
$293 nightly
The price is $322 total per night from Oct 1 to Oct 2
$322 total
Oct 1 - Oct 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (509 reviews)
"Amazing ✨✨✨✨"
Reviewed on Sep 18, 2025
Renaissance Panama City Hotel
Via España & Ricardo Arias Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $113 total per night from Oct 3 to Oct 4
$113 total
Oct 3 - Oct 4
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (63 reviews)
"The Room was very clean, all staff were very kind and professional, the breakfast and dinner are so delicious, nothing comparative with other restaurant around."
Reviewed on Sep 22, 2025
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Santa Maria Boulevard, Panama City
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Oct 3 to Oct 4
$243 total
Oct 3 - Oct 4
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (608 reviews)
"Staff was lovely - especially front desk, door staff, cleaning team and room service. Only critique is that service was very slow in the restaurant both times but otherwise a lovely visit."
Reviewed on Sep 18, 2025
W Panama
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $189 total per night from Oct 24 to Oct 25
$189 total
Oct 24 - Oct 25
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,006 reviews)
"This property was amazing and I enjoyed my stay. My only complaint was that the property needs to find a way to heat the pool at night. The pool is open 24 hours but at night it is so cold you can’t enjoy it."
Reviewed on Sep 15, 2025
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $194 total per night from Oct 25 to Oct 26
$194 total
Oct 25 - Oct 26
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,012 reviews)
"Excelent atention to detail, recomended stay."
Reviewed on Sep 20, 2025
Hilton Panama
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$243 nightly
The price is $268 total per night from Oct 11 to Oct 12
$268 total
Oct 11 - Oct 12
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,004 reviews)
"Great property You don’t go wrong Amenities are great Location is perfect area safe and walkable rooms are nice large clean modern"
Reviewed on Sep 14, 2025
Don't see what you're looking for?
See all available properties in Panama Canal Zone
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Panama Canal Zone Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Panama Canal Zone hotel reviews by fellow wanderers
Waymore Hotel Spa & Casino
5 out of 5
Posted 8 hours ago
Travelocity Verified Review
"The staff was wonderful"
A verified traveler stayed at Waymore Hotel Spa & Casino
Types of hotels
Hotels near…
Hotels by star rating
Areas of Panama Canal Zone
More ways to wander Panama Canal Zone
Most popular
Hotels
Flights
Activities