Explore the best 2025 4 Star Hotels Hotels in Serra Mesa
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Top Serra Mesa 4 Star hotels

Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$241 nightly
The price is $280 total per night
$280 total
Jul 20 - Jul 21
Total includes taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the hot tub and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

San Diego Marriott La Jolla
4240 La Jolla Village Dr, La Jolla, CA
Free Cancellation
Reserve now, pay when you stay
$197 nightly
The price is $227 total per night
$227 total
Jul 10 - Jul 11
Total includes taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. A bar/lounge, a 24-hour front desk, and a coffee shop are also provided.
Pool
Pet friendly

Marriott Marquis San Diego Marina
333 W Harbor Dr, San Diego, CA
$259 nightly
The price is $301 total per night
$301 total
Jul 20 - Jul 21
Total includes taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.
Pool
Hot Tub

Embassy Suites by Hilton San Diego Bay Downtown
601 Pacific Hwy, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$225 nightly
The price is $261 total per night
$261 total
Jul 7 - Jul 8
Total includes taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, express check-in, and valet parking. Enjoy the gym and free buffet breakfast each morning.
Pool
Breakfast included

DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$148 nightly
The price is $170 total per night
$170 total
Jul 8 - Jul 9
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, and express check-out. There's an indoor pool on site, and laundry facilities and wedding services are also offered.

Sheraton Mission Valley San Diego Hotel
1433 Camino Del Rio S, San Diego, CA
$134 nightly
The price is $154 total per night
$154 total
Jul 6 - Jul 7
Total includes taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a hot tub on site, and a 24-hour front desk and a terrace are also provided.
Pool
Hot Tub

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
$177 nightly
The price is $205 total per night
$205 total
Jul 20 - Jul 21
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and free airport shuttle. There's a bar/lounge on site, and concierge services and free newspapers are also provided.

DoubleTree by Hilton San Diego - Del Mar
11915 El Camino Real, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$171 nightly
The price is $195 total per night
$195 total
Aug 4 - Aug 5
Total includes taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 9 conference rooms, free WiFi in public areas, and express check-out. Enjoy the gym and unwind at the bar/lounge and poolside bar.
Pool
Hot Tub

Embassy Suites by Hilton San Diego La Jolla
4550 La Jolla Village Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$194 nightly
The price is $223 total per night
$223 total
Jul 27 - Jul 28
Total includes taxes and fees
This traditional hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and WiFi in public areas. Enjoy the gym and free perks like on-the-go breakfast and a beach shuttle.
Pool
Hot Tub

Lafayette Hotel & Club
2223 El Cajon Blvd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$244 nightly
The price is $280 total per night
$280 total
Jul 7 - Jul 8
Total includes taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the outdoor pool and conveniences like a 24-hour front desk and concierge services.
Pool
Pet friendly

Palihotel San Diego Gaslamp Quarter
830 Sixth Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$123 nightly
The price is $143 total per night
$143 total
Jul 22 - Jul 23
Total includes taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and dry cleaning are also offered.
Pet friendly
Free WiFi

Sheraton San Diego Resort
1380 Harbor Island Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$182 nightly
The price is $209 total per night
$209 total
Aug 5 - Aug 6
Total includes taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Enjoy the 2 hot tubs, and relax with drinks at the bar/lounge and poolside bar.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Serra Mesa hotels essential information
Accommodation | 8,799 hotels |
---|---|
Lowest Price | $143 |
Highest Price | $301 |
Popular hotels | Manchester Grand Hyatt San Diego, San Diego Marriott La Jolla, Marriott Marquis San Diego Marina, Embassy Suites by Hilton San Diego Bay Downtown, DoubleTree by Hilton Hotel San Diego - Mission Valley, Sheraton Mission Valley San Diego Hotel, Wyndham San Diego Bayside, DoubleTree by Hilton San Diego - Del Mar, Embassy Suites by Hilton San Diego La Jolla, Lafayette Hotel & Club, Palihotel San Diego Gaslamp Quarter, Sheraton San Diego Resort |
Recent Serra Mesa hotel reviews by fellow wanderers

DoubleTree by Hilton San Diego - Del Mar
5 out of 5
Posted 18 hours ago
Travelocity Verified Review
"Nice place, nice area, friendly staff "
A verified traveler stayed at DoubleTree by Hilton San Diego - Del Mar
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