Explore 18 Luxury Hotels in South San Francisco

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Best Luxury Hotels in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

250 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $162 total per night from Feb 28 to Mar 1
$162 total
Feb 28 - Mar 1
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,304 reviews)
Staff are all so nice

Reviewed on Feb 17, 2026

Opens in a new windowEmbassy Suites by Hilton San Francisco Airport Oyster Point
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

670 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $99 total per night from Mar 1 to Mar 2
$99 total
Mar 1 - Mar 2
Total with taxes and fees
A restaurant and a gym are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.6/10 Excellent! (1,001 reviews)
Everything was good during our stay

Reviewed on Feb 7, 2026

Opens in a new windowHilton Garden Inn San Francisco Arpt North
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

20 Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $127 total per night from Feb 23 to Feb 24
$127 total
Feb 23 - Feb 24
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8/10 Very Good! (2,013 reviews)
Staff was amazing and everything was clean, second time here and will be coming back.

Reviewed on Feb 15, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Francisco Airport N
Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North

121 E Grand Ave South San Francisco CA
$104 nightly
The price is $122 total per night from Feb 27 to Feb 28
$122 total
Feb 27 - Feb 28
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free airport pick-up. Business travelers can take advantage of the ...
7.8/10 Good! (1,004 reviews)
Clean room, comfy beds, friendly staff, great breakfast

Reviewed on Feb 17, 2026

Opens in a new windowComfort Inn and Suites San Francisco Airport North
Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco

690 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $129 total per night from Feb 20 to Feb 21
$129 total
Feb 20 - Feb 21
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the business center and onsite conference ...
7.8/10 Good! (1,003 reviews)
I enjoyed the stay and the breakfast was good

Reviewed on Feb 15, 2026

Opens in a new windowLarkspur Landing Extended Stay Suites South San Francisco
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave South San Francisco CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $115 total per night from Mar 13 to Mar 14
$115 total
Mar 13 - Mar 14
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and self parking. Enjoy freebies like on-the-go breakfast and a roundtrip airport shuttle ...
7.6/10 Good! (1,534 reviews)
Parking was no good. Had to park on red. Due to no space. yet I had to pay for parking. Staff was friendly. Other than that it was ok

Reviewed on Feb 17, 2026

Opens in a new windowHotel Focus SFO
Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

326 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $72 total per night from Mar 1 to Mar 2
$72 total
Mar 1 - Mar 2
Total with taxes and fees
A restaurant and an outdoor pool are featured at this motel. Traveling on business? Take advantage of the free WiFi in public areas, conference space, and free ...
5.8/10 (3,193 reviews)
Room in good condition but i really think or suggest more front desk employee.

Reviewed on Feb 17, 2026

Opens in a new windowTravelodge by Wyndham San Francisco Airport North
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $83 total per night from Feb 18 to Feb 19
$83 total
Feb 18 - Feb 19
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A lobby fireplace, a picnic area, and luggage storage are also on ...
5.8/10 (1,005 reviews)
The room was awful, the carpets had what appeared to be vomit stains all over. The shower had zero hot water, maybe room temperature if you're lucky. Not to mention there was black mold on the walls of the shower. Also, the AC did not work which made sleeping miserable. The bed was hard as a rock ...

Reviewed on Feb 15, 2026

Opens in a new windowPark Pointe Hotel
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5 star hotels in South San Francisco

South San Francisco Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South San Francisco luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South San Francisco to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South San Francisco will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South San Francisco, and plan your next opulent escape.


South San Francisco hotels essential information

Accommodation
5,168 hotels
Lowest Price
$72
Highest Price
$527
Popular hotels
Travelodge by Wyndham San Francisco Airport North, Hotel Focus SFO, Comfort Inn and Suites San Francisco Airport North, Embassy Suites by Hilton San Francisco Airport Oyster Point, Hilton Garden Inn San Francisco Arpt North, Larkspur Landing Extended Stay Suites South San Francisco, Park Pointe Hotel, La Quinta Inn & Suites by Wyndham San Francisco Airport N

Popular Luxury Stays in South San Francisco

Recent South San Francisco Hotel Reviews By Fellow Wanderers

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