Explore 18 Luxury Hotels in South San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

250 Gateway Blvd South San Francisco CA
$147 nightly
The price is $172 total per night from Jan 8 to Jan 9
$172 total
Jan 8 - Jan 9
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.4/10 Very Good! (1,246 reviews)
Every was good and fresh

Reviewed on Dec 28, 2025

Opens in a new windowEmbassy Suites by Hilton San Francisco Airport Oyster Point
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

670 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $124 total per night from Jan 8 to Jan 9
$124 total
Jan 8 - Jan 9
Total with taxes and fees
A restaurant and a gym are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.4/10 Very Good! (1,005 reviews)
Reception staff very friendly and helpful

Reviewed on Dec 29, 2025

Opens in a new windowHilton Garden Inn San Francisco Arpt North
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

20 Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $119 total per night from Jan 3 to Jan 4
$119 total
Jan 3 - Jan 4
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8/10 Very Good! (2,015 reviews)
I have no complaints. The staff was excellent! The dining staff kept me smiling. So friendly.

Reviewed on Dec 31, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Francisco Airport N
Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North

121 E Grand Ave South San Francisco CA
$92 nightly
The price is $109 total per night from Jan 4 to Jan 5
$109 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free airport pick-up. Business travelers can take advantage of the ...
7.6/10 Good! (1,003 reviews)
Good

Reviewed on Dec 7, 2025

Opens in a new windowComfort Inn and Suites San Francisco Airport North
Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco

690 Gateway Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Jan 5 to Jan 6
$116 total
Jan 5 - Jan 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the business center and onsite conference ...
7.6/10 Good! (1,001 reviews)
Overall good!

Reviewed on Dec 3, 2025

Opens in a new windowLarkspur Landing Extended Stay Suites South San Francisco
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave South San Francisco CA
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $101 total per night from Jan 23 to Jan 24
$101 total
Jan 23 - Jan 24
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and self parking. Enjoy freebies like on-the-go breakfast and a roundtrip airport shuttle ...
7.4/10 Good! (1,536 reviews)
No

Reviewed on Dec 29, 2025

Opens in a new windowHotel Focus SFO
Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

326 S Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $70 total per night from Jan 25 to Jan 26
$70 total
Jan 25 - Jan 26
Total with taxes and fees
A restaurant and an outdoor pool are featured at this motel. Traveling on business? Take advantage of the free WiFi in public areas, conference space, and free ...
5.8/10 (2,989 reviews)
Clean room, nice staff, super convenient location, great price!

Reviewed on Dec 30, 2025

Opens in a new windowTravelodge by Wyndham San Francisco Airport North
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd South San Francisco CA
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A lobby fireplace, a picnic area, and luggage storage are also on ...
5.6/10 (1,001 reviews)
Great place plenty of parking spaces and clean rooms good prices 👍

Reviewed on Nov 21, 2025

Opens in a new windowPark Pointe Hotel
Don't see what you're looking for?
See all available properties in South San Francisco
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in South San Francisco

5 star hotels in South San Francisco

South San Francisco Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South San Francisco luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South San Francisco to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South San Francisco will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South San Francisco, and plan your next opulent escape.


South San Francisco hotels essential information

Accommodation
5,163 hotels
Lowest Price
$70
Highest Price
$453
Popular hotels
Travelodge by Wyndham San Francisco Airport North, Hotel Focus SFO, Comfort Inn and Suites San Francisco Airport North, Embassy Suites by Hilton San Francisco Airport Oyster Point, Hilton Garden Inn San Francisco Arpt North, Larkspur Landing Extended Stay Suites South San Francisco, Park Pointe Hotel, La Quinta Inn & Suites by Wyndham San Francisco Airport N

Popular Luxury Stays in South San Francisco

Recent South San Francisco Hotel Reviews By Fellow Wanderers

Explore More Ways to Travel with Travelocity