Find and compare 5 Star hotels in Lake Nona Medical City

This luxury hotel features a golf course, a full-service spa, and 6 restaurants. There's fun for all ages with a lazy river and a children's club, and families will appreciate the onsite laundry facilities. Enjoy the 2 outdoor pools and perks like a free theme park shuttle.

This luxury hotel features a private beach, a golf course, and a full-service spa. Relax with beach cabanas, sun loungers, and beach umbrellas. Bring the family and enjoy the children's club, children's pool, and waterslide.

This luxury resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and babysitting is an added bonus. Traveling on business? Take advantage of the 24-hour business center, express check-out, and valet parking.

This smoke-free hotel features a golf course, a full-service spa, and 7 restaurants. There's fun for all ages with a lazy river and a children's club, and families will appreciate the onsite laundry facilities. Traveling on business? Take advantage of the business center, express check-in, and airport shuttle.

This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a free kid's club and a children's pool, and barbecue grills are available on site. Enjoy the 2 outdoor tennis courts and perks like free self parking and a free theme park shuttle.

This luxury aparthotel features a golf course, free water park access, and 7 restaurants. Bring the family and enjoy the lazy river, mini golf, and kid-friendly dining. Relax with a drink at one of the 2 poolside bars and enjoy the 11 outdoor pools and gym.

Free WiFi in public areas is available at this vacation home. Take advantage of the free self parking.

Free water park access and an outdoor pool are featured at this luxury villa. Enjoy the 24-hour gym and perks like free self parking. A garden, a picnic area, and barbecue grills are also on offer.

Stay at this 5-star luxury cottage in Kissimmee. Enjoy free WiFi, free parking, and a patio. Popular attractions Disney's Animal Kingdom® Theme Park and ESPN Wide World of Sports are located nearby. Discover genuine guest reviews for Up to Scale at Margaritaville along with the latest prices and availability – book now.

This villa features an outdoor pool and a gym. Free self parking, a garden, and a picnic area are also offered.

This villa features an outdoor pool and a gym. Free self parking, a garden, and a picnic area are also offered.

This villa features an outdoor pool and a gym. Enjoy the spa tub and perks like free self parking and free WiFi. There's a poolside bar on site, and a terrace and laundry facilities are also provided.