
$2,798 Cheap American Airlines flights from Santo Domingo to Brussels (SDQ to BRU)
Find The Best Day To Fly from Santo Domingo to Brussels
Amazing American Airlines SDQ to BRU Flight Deals
The cheapest flights to Brussels - National found within the past 7 days were $4,353 round trip and $2,798 one way. Prices and availability subject to change. Additional terms may apply.
Discover our best American Airlines flight from Santo Domingo SDQ to Brussels BRU
To find the best deals on flights to Santo Domingo from Brussels with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Santo Domingo SDQ to Brussels BRU with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $4,353 to $4,353, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Santo Domingo SDQ to Brussels BRU
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Santo Domingo to Brussels costs from $2,798. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Brussels BRU from Santo Domingo SDQ with American Airlines
To find a cheap American Airlines flight from Santo Domingo SDQ to Brussels BRU, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Santo Domingo SDQ to Brussels BRU
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as December, or if you book a flight with a stopover.
Find nonstop flights from Santo Domingo SDQ to Brussels BRU with American Airlines
If you’re keen to be on Brussels soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Santo Domingo SDQ to Brussels BRU
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Brussels BRU from Santo Domingo SDQ with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
|---|---|---|---|
| DFW | USA | Dallas-Fort Worth Intl. | 599 |
| CLT | USA | Charlotte-Douglas Intl. | 536 |
| ORD | USA | O'Hare Intl. | 317 |
| PHL | USA | Philadelphia Intl. | 247 |
| MIA | USA | Miami Intl. | 193 |
| DCA | USA | Ronald Reagan Washington National | 152 |
| PHX | USA | Sky Harbor Intl. | 141 |
| LAX | USA | Los Angeles Intl. | 81 |
| LGA | USA | LaGuardia | 72 |
| BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Brussels

Holiday Inn Express Brussels Airport by IHG
Simple but comfy hotel. Selected hotel due to early shuttle availability as there is a shuttle at 4:40am to the airport. Bed and pillows were comfy, spacious room, with iron and drier. A restaurant for a quick meal . It is good for an overnight stay for an early flight. I think the shuttle is available ...
Reviewed on Nov 3, 2025

Aparthotel Adagio Access Brussels Airport
Great place, glad they had laundry facilities. Staff were extremely helpful. Great breakfast. Spacious room.
Reviewed on Nov 2, 2025

Courtyard by Marriott Brussels
The breakfast options was ok to good. Location was good. Parking was great, gym was adequate. The friendliness of the staff was great. Facility was a little dated but good
Reviewed on Nov 3, 2025
