$122 Cheap American Airlines flights from Cleveland to Des Moines (CLE to DSM)

Find The Best Day To Fly from Cleveland to Des Moines

Amazing American Airlines CLE to DSM Flight Deals

The cheapest flights to Des Moines Intl. found within the past 7 days were $261 round trip and $122 one way. Prices and availability subject to change. Additional terms may apply.

Fri, Aug 8 - Mon, Aug 11
CLE
Cleveland
DSM
Des Moines
$261 Roundtrip, found 9 hours ago
$261
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Aug 8 from Cleveland to Des Moines, returning Mon, Aug 11, priced at $261 found 9 hours ago
Sun, Aug 17 - Sun, Aug 24
CLE
Cleveland
DSM
Des Moines
$281 Roundtrip, found 2 days ago
$281
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Aug 17 from Cleveland to Des Moines, returning Sun, Aug 24, priced at $281 found 2 days ago
Fri, Aug 8 - Mon, Aug 11
CLE
Cleveland
DSM
Des Moines
$292 Roundtrip, found 9 hours ago
$292
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Aug 8 from Cleveland to Des Moines, returning Mon, Aug 11, priced at $292 found 9 hours ago
Fri, Aug 8 - Mon, Aug 11
CLE
Cleveland
DSM
Des Moines
$296 Roundtrip, found 9 hours ago
$296
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Aug 8 from Cleveland to Des Moines, returning Mon, Aug 11, priced at $296 found 9 hours ago
Fri, Aug 8 - Mon, Aug 11
CLE
Cleveland
DSM
Des Moines
$298 Roundtrip, found 9 hours ago
$298
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Aug 8 from Cleveland to Des Moines, returning Mon, Aug 11, priced at $298 found 9 hours ago
Mon, Sep 8 - Sat, Sep 13
CLE
Cleveland
DSM
Des Moines
$307 Roundtrip, found 1 day ago
$307
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Sep 8 from Cleveland to Des Moines, returning Sat, Sep 13, priced at $307 found 1 day ago

Frequently asked questions

Can I catch a flight from CLE to Des Moines Intl. Airport (DSM) right now?
It's prudent to know about any quarantine requirements and travel advice reports in place in your destination city. Make sure you visit the Covid-19 Travel Advisor for up-to-date information on catching a flight to Des Moines Intl. Airport from CLE.
What terminal is American Airlines at Hopkins Intl. Airport (CLE)?
Check your boarding pass to find out which Cleveland Hopkins Intl. Airport terminal you'll be departing from on your way to Des Moines Intl. Airport (DSM) with American Airlines. If you can't find the details on there, get in touch with your airline.
Are there American Airlines non-stop flights from CLE to DSM?
You won't find any nonstop flights with American Airlines from CLE to DSM. But think of it this way --- you can make the most of this time to stretch your legs before jumping on your connecting flight.
How long is an American Airlines flight from CLE to DSM?
As it will take around 5 hours for your American Airlines flight to head from CLE to DSM, think about throwing some travel games in your carry-on. You never know --- the person sitting beside you might relish the chance to play to break up the journey.
How many direct and indirect flights does American Airlines fly from CLE to DSM?
American Airlines currently offers approximately 2 flights each day from Hopkins Intl. Airport (CLE) to Des Moines Intl. Airport.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to DSM, please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.
American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

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Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave, Des Moines, IA
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. ...
8.4/10 Very Good! (1,551 reviews)
"Stayed there many times and quality is always the same. Wonderful."

Reviewed on Jul 15, 2025

Days Inn & Suites by Wyndham Des Moines Airport
AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport

2.5 out of 5
1920 Hackley Ave, Des Moines, IA
This hotel doesn't skimp on freebies - guests receive free full breakfast, free self parking, and a free airport shuttle. Traveling on business? Take advantage ...
7.8/10 Good! (1,006 reviews)
"Absolutely fabulous stay. Comfy bed, clean room, fabulous staff. The GM was awesome at check in!"

Reviewed on Jul 3, 2025

AmericInn by Wyndham Des Moines Airport
Clarion Inn Des Moines Airport

Clarion Inn Des Moines Airport

3 out of 5
1810 Army Post Road, Des Moines, IA
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
6.8/10 (57 reviews)
"The staff was extremely helpful."

Reviewed on Jul 16, 2025

Clarion Inn Des Moines Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.