$170 Cheap American Airlines flights from Chicago to Knoxville (ORD to TYS)

Find The Best Day To Fly from Chicago to Knoxville

Amazing American Airlines ORD to TYS Flight Deals

The cheapest flights to McGhee Tyson found within the past 7 days were $193 round trip and $170 one way. Prices and availability subject to change. Additional terms may apply.

Mon, Aug 4 - Sat, Aug 9
ORD
Chicago
TYS
Knoxville
$193 Roundtrip, found 1 hour ago
$193
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, Aug 4 from Chicago to Knoxville, returning Sat, Aug 9, priced at $193 found 1 hour ago
Wed, Jul 2 - Tue, Jul 8
ORD
Chicago
TYS
Knoxville
$199 Roundtrip, found 2 hours ago
$199
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jul 2 from Chicago to Knoxville, returning Tue, Jul 8, priced at $199 found 2 hours ago
Sat, Sep 6 - Sat, Sep 13
ORD
Chicago
TYS
Knoxville
$214 Roundtrip, found 2 days ago
$214
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Sep 6 from Chicago to Knoxville, returning Sat, Sep 13, priced at $214 found 2 days ago
Mon, Aug 4 - Sat, Aug 9
ORD
Chicago
TYS
Knoxville
$219 Roundtrip, found 1 hour ago
$219
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, Aug 4 from Chicago to Knoxville, returning Sat, Aug 9, priced at $219 found 1 hour ago
Tue, Oct 21 - Tue, Oct 28
ORD
Chicago
TYS
Knoxville
$224 Roundtrip, found 1 day ago
$224
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from Chicago to Knoxville, returning Tue, Oct 28, priced at $224 found 1 day ago
Mon, Aug 4 - Sat, Aug 9
ORD
Chicago
TYS
Knoxville
$228 Roundtrip, found 1 hour ago
$228
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, Aug 4 from Chicago to Knoxville, returning Sat, Aug 9, priced at $228 found 1 hour ago

TYS From ORD Economy Coach Packages on Similar Airlines

Price found within the past 48 hours. Click for updated prices.
River Terrace Resort & Convention Center

River Terrace Resort & Convention Center

3.5 out of 5
Save 100% on your flight
per person
Jul 3 - Jul 7
found 11 hours ago
Roundtrip flight included
Chicago (MDW) to Knoxville (TYS)
Westgate Smoky Mountain Resort & Water Park

Westgate Smoky Mountain Resort & Water Park

4 out of 5
Save 100% on your flight
per person
Jul 3 - Jul 7
found 11 hours ago
Roundtrip flight included
Chicago (MDW) to Knoxville (TYS)
The Lodges at the Great Smoky Mountains

The Lodges at the Great Smoky Mountains

4 out of 5
Save 100% on your flight
per person
Jul 6 - Jul 13
found 14 hours ago
Roundtrip flight included
Chicago (ORD) to Knoxville (TYS)
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Frequently asked questions

Can I catch a flight from O'Hare Airport to Knoxville Airport right now?
Make sure you visit our Covid-19 Travel Advisor to see if there are any current travel advice reports or quarantine requirements in effect in McGhee Tyson Airport (TYS) when flying from O'Hare Airport.
What terminal is American Airlines at O'Hare Airport?
If you're flying with American Airlines from O'Hare Intl. Airport (ORD), you'll generally catch your flight from terminal 3. If you're traveling to McGhee Tyson Airport (TYS) from here, you'll likely be filing off the aircraft at the main terminal.
Are there American Airlines non-stop flights from ORD to TYS?
If you need to get from O'Hare Airport to McGhee Tyson Airport (TYS) and want a nonstop flight, American Airlines can help. Lock in your seat now and you'll be vacationing at your destination before you know it.
How long is an American Airlines flight from ORD to TYS?
Your American Airlines flight should take you from ORD to TYS in approximately 2 hours and 34 minutes. If you're not a huge fan of talking to fellow passengers while you're on the plane, don't worry --- you won't have to make small talk for too long.
What type of aircraft does American Airlines fly from ORD to TYS?
American Airlines usually operates either the Embraer 175 or the Embraer 170 between ORD and TYS.
How many direct and indirect flights does American Airlines fly from ORD to TYS?
If you're considering a trip from ORD to TYS, you can pick from at least 3 American Airlines flights each day.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to Knoxville Airport, please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.
American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

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La Quinta Inn & Suites by Wyndham Knoxville Airport
3 out of 5
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3.5 out of 5
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Hilton Knoxville Airport
Best Western Knoxville Airport/Alcoa
Best Western Knoxville Airport/Alcoa
2.5 out of 5
162 Cusick Rd, Alcoa, TN
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
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Reviewed on Jun 15, 2025

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.