Explore 7 Luxury Hotels in Santo Spirito

Best Luxury Hotels in Santo Spirito

Palazzo Guicciardini

via Santo Spirito 14, First floor, Florence, FI

This guesthouse features a bar/lounge, free WiFi in public areas, and a library. Dry cleaning, luggage storage, and laundry facilities are also on offer.

9.2/10 Wonderful! (147 reviews)

"The hotel was difficult to find. Located in a side alley space. To enter, you had to buzz to get in, then enter a dark, metal gated area, then walk a dimly lit area to locate an unmarked door which was a lift. There was a young woman who checked us in. We didn’t see anyone at the desk till days later ..."

Reviewed on May 31, 2025

Get rates

Hotel Palazzo Guadagni

Piazza Santo Spirito 9, Florence, FI

$334 nightly

$382 total

Jun 12 - Jun 13

Total includes taxes and fees

This hotel features a rooftop terrace and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and valet parking. ...

9/10 Wonderful! (194 reviews)

"The warm and friendly staff.Excellent breakfast. Beautiful loggia overlooking Florence"

Reviewed on May 20, 2025

UNA HOTELS Vittoria Firenze

Via Pisana 59, Florence, FI

Fully refundableReserve now, pay when you stay

$127 nightly

$156 total

Jun 8 - Jun 9

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...

8.4/10 Very Good! (987 reviews)

"It was average really. Needs to be updated in the rooms blobby area and outside was very nice"

Reviewed on May 31, 2025

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

La Terrazza su Boboli

viale Francesco Petrarca 122, Florence, FI

This hotel features a bar/lounge, a coffee shop, and free WiFi in public areas. A terrace, a snack bar/deli, and a lobby fireplace are also on offer.

Great location

"An overnight stay as we travelled from Italy to France. A great and comfortable night and fantastic breakfast."

Reviewed on Nov 11, 2019

Get rates

Convitto della Calza - Holiday Home

Piazza Della Calza 6, Florence, FI

A restaurant and a gym are featured at this hotel. Traveling for business? Take advantage of the free WiFi in public areas, express check-in, and conference ...

"Clean, fair for the price Three stars at most Staff were very friendly A short bus ride away from city attractions Bus stop outside the hotel"

Reviewed on Oct 25, 2019

Get rates

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santo Spirito Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santo Spirito luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Santo Spirito to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Santo Spirito will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santo Spirito, and plan your next opulent escape.

Santo Spirito hotels essential information

Accommodation	452 hotels
Lowest Price	$156
Highest Price	$382
Popular hotels	Palazzo Guicciardini, La Terrazza su Boboli, UNA HOTELS Vittoria Firenze, Convitto della Calza - Holiday Home, Hotel Palazzo Guadagni

Popular Luxury Stays in Santo Spirito

Popular places to visit

Piazza Santo Spirito

5/5(1 review)

Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and stunning cathedral in this vibrant area.