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Top hotels close to Museum of Life and Science

Bull City Bungalow Walk to Ninth St Near Duke
Durham NC
0.62 mi from Museum of Life and Science
$362 nightly
The price is $411 total per night
$411 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A garden is available at this vacation home.
Kitchen
Washer

Hampton Inn & Suites Durham/North I-85
1542 North Gregson Street Durham NC
Free Cancellation
Reserve now, pay when you stay
0.84 mi from Museum of Life and Science
$103 nightly
The price is $117 total per night
$117 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free perks include buffet breakfast, free self parking, and an area shuttle.
Pool
Breakfast included

Tiny Home a fantastic Location close to 9th Street!
Durham NC
1.1 mi from Museum of Life and Science
This vacation home includes a garden and laundry facilities.

The Duke Retreat | Close to Duke & Downtown
Durham NC
1.15 mi from Museum of Life and Science
$314 nightly
The price is $331 total per night
$331 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
This vacation home features laundry facilities.

New Cozy Durham 2 Bedroom Home B
Durham NC
1.22 mi from Museum of Life and Science
Free WiFi in public areas is available at this apartment.

Cozy Bungalow in the Heart of Durham, DPAC, Duke
Durham NC
1.26 mi from Museum of Life and Science
$268 nightly
The price is $303 total per night
$303 total
Dec 15 - Dec 16
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.

Super 8 by Wyndham Durham/University Area NC
2337 Guess Rd Durham NC
Free Cancellation
Reserve now, pay when you stay
1.29 mi from Museum of Life and Science
$64 nightly
The price is $72 total per night
$72 total
Dec 26 - Dec 27
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. Dry cleaning and free newspapers are also provided.

Red Roof Inn Durham - Duke Univ Medical Center
1915 N Pointe Drive Durham NC
Free Cancellation
Reserve now, pay when you stay
1.34 mi from Museum of Life and Science
$60 nightly
The price is $68 total per night
$68 total
Dec 21 - Dec 22
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. WiFi in public areas is free. A safe deposit box is also provided.
Pet friendly
Parking included

Holiday Inn Express Durham by IHG
2516 Guess Rd Durham NC
Free Cancellation
1.35 mi from Museum of Life and Science
$92 nightly
The price is $104 total per night
$104 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free self parking, and a free area shuttle. Traveling on business? Take advantage of the business center and free WiFi in public areas. There's an outdoor pool on site, and laundry facilities and free newspapers are also offered.
Pool
Breakfast included

Comfort Inn & Suites Durham near Duke University
1816 Hillandale Rd Durham NC
Free Cancellation
Reserve now, pay when you stay
1.99 mi from Museum of Life and Science
$95 nightly
The price is $108 total per night
$108 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like on-the-go breakfast and free self parking.
Pool
Breakfast included

Unscripted Durham, Part of JDV by Hyatt
202 N Corcoran St Durham NC
Free Cancellation
Reserve now, pay when you stay
2.27 mi from Museum of Life and Science
$142 nightly
The price is $161 total per night
$161 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. You'll appreciate the 24-hour gym, poolside bar, and rooftop terrace.
Pool
Pet friendly

21c Museum Hotel Durham
111 North Corcoran Street Durham NC
Free Cancellation
Reserve now, pay when you stay
2.32 mi from Museum of Life and Science
$166 nightly
The price is $188 total per night
$188 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Enjoy the sauna and perks like free WiFi. Valet parking, a 24-hour business center, and dry cleaning are also offered.
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See all available properties in Museum of Life and Science
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Museum of Life and Science hotels essential information
Accommodation | 945 hotels |
|---|---|
Lowest Price | $68 |
Highest Price | $411 |
Popular hotels | Hampton Inn & Suites Durham/North I-85, Holiday Inn Express Durham by IHG, Bull City Bungalow Walk to Ninth St Near Duke, Comfort Inn & Suites Durham near Duke University, Red Roof Inn Durham - Duke Univ Medical Center, Unscripted Durham, Part of JDV by Hyatt, Tiny Home a fantastic Location close to 9th Street!, Super 8 by Wyndham Durham/University Area NC, The Duke Retreat | Close to Duke & Downtown, 21c Museum Hotel Durham, New Cozy Durham 2 Bedroom Home B, Cozy Bungalow in the Heart of Durham, DPAC, Duke |
Recent Museum of Life and Science hotel reviews by fellow wanderers

Comfort Inn & Suites Durham near Duke University
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Beautiful newly remodeled room."
A verified traveler stayed at Comfort Inn & Suites Durham near Duke University
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