Explore 57 Luxury Hotels in Central Missouri

Name: Super 8 by Wyndham Columbia Clark Lane
Price range: $64 total
Rating: 6.4

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Best Luxury Hotels in Central Missouri

Camden on the Lake Resort & Spa

2359 Bittersweet Road Lake Ozark MO

$136 nightly

$145 total

Nov 20 - Nov 21

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas and free ...

9/10 Wonderful! (1,001 reviews)

Awesome staff, great food and service!!

Reviewed on Nov 14, 2025

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St, Sedalia, MO

Fully refundable

$112 nightly

$127 total

Dec 12 - Dec 13

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...

9/10 Wonderful! (570 reviews)

Our room was beautiful and spotless, the front desk personnel were friendly and knowledgeable about the history of the hotel, the wait staff at the restaurant were efficient and friendly. Our experience here was wonderful and we look forward to our next visit.

Reviewed on Nov 10, 2025

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

Fully refundable

$154 nightly

$174 total

Nov 28 - Nov 29

Total with taxes and fees

A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...

8.8/10 Excellent! (1,000 reviews)

Had a great stay and the whole staff was wonderful. Nice and walkable area, including early morning & evenings.

Reviewed on Nov 12, 2025

Best Western Plus Columbia Inn

2904 Clark Lane Columbia MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...

8.8/10 Excellent! (1,198 reviews)

Clean room. Excellent breakfast. Good staff

Reviewed on Nov 13, 2025

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

Fully refundableReserve now, pay when you stay

$61 nightly

$69 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

7.4/10 Good! (1,005 reviews)

🤗

Reviewed on Nov 14, 2025

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr., Lake Ozark, MO

Fully refundableReserve now, pay when you stay

$92 nightly

$100 total

Dec 3 - Dec 4

Total with taxes and fees

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...

7.2/10 Good! (1,067 reviews)

Efficient

Reviewed on Nov 13, 2025

Laci's Country Inn

410 N Vaughn St Knob Noster MO

$66 nightly

$72 total

Nov 18 - Nov 19

Total with taxes and fees

Free WiFi in public areas is available at this motel. Take advantage of the free self parking.

6.8/10 (159 reviews)

The room was adequate sized and the tv worked well. Nice shower!

Reviewed on Jul 6, 2025

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln Columbia MO

Fully refundableReserve now, pay when you stay

$57 nightly

$64 total

Nov 23 - Nov 24

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.4/10 (1,001 reviews)

Yes

Reviewed on Oct 13, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Central Missouri

Shore Thing - Lakefront for 12

1459 Ginger Rd, Lake Ozark, Mo 65049, Lake Ozark MO

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Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.

Central Missouri hotels essential information

Accommodation	4,776 hotels
Lowest Price	$64
Highest Price	$174
Popular hotels	Ramada by Wyndham Columbia, voco The Tiger Hotel Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane