Explore 57 Luxury Hotels in Central Missouri

Name: Ramada by Wyndham Columbia
Price range: $81 total
Rating: 7.6

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Best Luxury Hotels in Central Missouri

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St Sedalia MO

Fully refundable

$115 nightly

$131 total

May 10 - May 11

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...

9.2/10 Wonderful! (602 reviews)

Yes, fresh and extensive, much more so than I would have thought a Continental breakfast would be!

Reviewed on Apr 4, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

Fully refundable

$162 nightly

$184 total

Apr 26 - Apr 27

Total with taxes and fees

A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9/10 Wonderful! (1,002 reviews)

Not super happy with this property. My room was dirty and pillows at this property are horrible - hard and overly stuffed - I could not sleep and ended up using towels. It would sound like I’m a pillow snob but have never complained about pillows in my life at the 100+ stays I’ve had in hotels. These ...

Reviewed on Apr 7, 2026

Camden on the Lake Resort & Spa

2359 Bittersweet Road Lake Ozark MO

$167 nightly

$178 total

Apr 12 - Apr 13

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas and free ...

9/10 Wonderful! (1,000 reviews)

Loved it!

Reviewed on Apr 6, 2026

Best Western Plus Columbia Inn

2904 Clark Lane Columbia MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Apr 19 - Apr 20

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...

8.8/10 Excellent! (1,288 reviews)

Yes excellent accomodations

Reviewed on Apr 5, 2026

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Apr 12 - Apr 13

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

7.6/10 Good! (1,001 reviews)

Horrible experience. Property not maintaining well at all. Would not recommend.

Reviewed on Apr 4, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

Fully refundableReserve now, pay when you stay

$155 nightly

$169 total

Apr 20 - Apr 21

Total with taxes and fees

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...

7.4/10 Good! (1,111 reviews)

Excellent off season stay. Peaceful. Great views. Highly recommend.

Reviewed on Apr 7, 2026

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln Columbia MO

Fully refundableReserve now, pay when you stay

$61 nightly

$69 total

Apr 20 - Apr 21

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.6/10 (1,002 reviews)

Reviewed on Apr 8, 2026

Laci's Country Inn

410 N Vaughn St Knob Noster MO

Free WiFi in public areas is available at this motel. Take advantage of the free self parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.

Central Missouri hotels essential information

Accommodation	5,011 hotels
Lowest Price	$69
Highest Price	$184
Popular hotels	Ramada by Wyndham Columbia, voco The Tiger Hotel Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane