Explore 57 Luxury Hotels in Central Missouri

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Best Luxury Hotels in Central Missouri

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St Sedalia MO
Fully refundable
$124 nightly
The price is $141 total per night from Jun 7 to Jun 8
$141 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
9.2/10 Wonderful! (616 reviews)
"Amazing experience! Service was above and beyond and the room was spotless."

Reviewed on May 21, 2026

Opens in a new windowHotel Bothwell Sedalia Central District, an Ascend Collection Hotel
voco The Tiger Hotel Columbia, MO by IHG

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO
Fully refundable
$175 nightly
The price is $199 total per night from Jun 5 to Jun 6
$199 total
Jun 5 - Jun 6
Total with taxes and fees
A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9/10 Wonderful! (1,002 reviews)
"We loved the quiet and clean room! The patio was nice for hanging out too!"

Reviewed on May 25, 2026

Opens in a new windowvoco The Tiger Hotel Columbia, MO by IHG
Camden on the Lake Resort & Spa

Camden on the Lake Resort & Spa

2359 Bittersweet Road Lake Ozark MO
$187 nightly
The price is $200 total per night from May 31 to Jun 1
$200 total
May 31 - Jun 1
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas and free ...
9/10 Wonderful! (1,000 reviews)
"Na"

Reviewed on May 19, 2026

Opens in a new windowCamden on the Lake Resort & Spa
Best Western Plus Columbia Inn

Best Western Plus Columbia Inn

2904 Clark Lane Columbia MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from May 31 to Jun 1
$79 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
8.8/10 Excellent! (1,319 reviews)
"Pretty standard regular hotel. Generally clean, nice hot breakfast, very cold indoor pool. Shower was a little tricky to get the right temp (and friends staying in a different room had a shower that they couldn't get to be anything but scalding hot). Staff wouldn't give extra pillows for the sofa ..."

Reviewed on May 26, 2026

Opens in a new windowBest Western Plus Columbia Inn
Ramada by Wyndham Columbia

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $78 total per night from May 27 to May 28
$78 total
May 27 - May 28
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
7.6/10 Good! (1,012 reviews)
"It was ok. Needs more updated stuff."

Reviewed on May 26, 2026

Opens in a new windowRamada by Wyndham Columbia
Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $175 total per night from Jun 4 to Jun 5
$175 total
Jun 4 - Jun 5
Total with taxes and fees
This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...
7.4/10 Good! (1,130 reviews)
"Staff are so helpful and friendly. I have stayed here numerous times and will keep coming back!"

Reviewed on May 26, 2026

Opens in a new windowLodge Of Four Seasons Golf Resort, Marina & Spa
Super 8 by Wyndham Columbia Clark Lane

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln Columbia MO
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $67 total per night from May 27 to May 28
$67 total
May 27 - May 28
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...
6.6/10 (1,001 reviews)
"Clean room, better than expected."

Reviewed on May 25, 2026

Opens in a new windowSuper 8 by Wyndham Columbia Clark Lane
Laci's Country Inn

Laci's Country Inn

410 N Vaughn St Knob Noster MO
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
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Opens in a new windowLaci's Country Inn
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More 4 star hotels in Central Missouri

Osage Beach Condo w/ Private Deck & Lake Views!

Osage Beach Condo w/ Private Deck & Lake Views!

Osage Beach MO
Get rates

Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.


Central Missouri hotels essential information

Accommodation
5,122 hotels
Lowest Price
$67
Highest Price
$200
Popular hotels
Ramada by Wyndham Columbia, voco The Tiger Hotel Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane

Popular Luxury Stays in Central Missouri

5 Stars Luxury stays in Central Missouri
Hotels 5 Stars
Hotels 5 Stars
Luxury stays in Central Missouri with spa
Hotels with Spa
Hotels with Spa

Recent Central Missouri Hotel Reviews By Fellow Wanderers

Capitol Plaza Hotel Jefferson City

Capitol Plaza Hotel Jefferson City

4 out of 5
Posted 6 hours ago
Travelocity Verified Review
"The hotel was fine. It was old and needed to be updated. Water temps were all over the place, but the breakfast was good and staff were nice. I would stay there again."
A verified traveler stayed at Capitol Plaza Hotel Jefferson City
Capitol Plaza Hotel Jefferson City

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