Explore 57 Luxury Hotels in Central Missouri

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Central Missouri

Camden on the Lake Resort & Spa

Camden on the Lake Resort & Spa

2359 Bittersweet Road, Lake Ozark, MO
$156 nightly
The price is $167 total per night from Oct 5 to Oct 6
$167 total
Oct 5 - Oct 6
Total with taxes and fees
This smoke-free resort features a full-service spa, a nightclub, and a marina. Traveling on business? Take advantage of the 24-hour business center and free ...
9/10 Wonderful! (1,001 reviews)
"Beautiful property....a little pricey, restaurant portions kinda small for the hefty prices...rooms where Beautiful and the beds were comfy!"

Reviewed on Sep 16, 2025

Opens in a new windowCamden on the Lake Resort & Spa
Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel

103 E 4th St, Sedalia, MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $125 total per night from Nov 2 to Nov 3
$125 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
9/10 Wonderful! (556 reviews)
"Great place to stay while biking the Ksty trail Old, comfortable, convenient a really neat place to stay. Loved it"

Reviewed on Sep 25, 2025

Opens in a new windowHotel Bothwell Sedalia Central District, an Ascend Collection Hotel
voco, The Tiger Hotel, Columbia, MO by IHG

voco, The Tiger Hotel, Columbia, MO by IHG

23 S 8th St, Columbia, MO
Fully refundable
$171 nightly
The price is $194 total per night from Oct 30 to Oct 31
$194 total
Oct 30 - Oct 31
Total with taxes and fees
A nightclub, 3 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...
8.8/10 Excellent! (1,004 reviews)
"Fancy"

Reviewed on Sep 21, 2025

Opens in a new windowvoco, The Tiger Hotel, Columbia, MO by IHG
Best Western Plus Columbia Inn

Best Western Plus Columbia Inn

2904 Clark Lane, Columbia, MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from Oct 8 to Oct 9
$81 total
Oct 8 - Oct 9
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
8.8/10 Excellent! (1,191 reviews)
"traffic was very noisy outside"

Reviewed on Sep 26, 2025

Opens in a new windowBest Western Plus Columbia Inn
Ramada by Wyndham Columbia

Ramada by Wyndham Columbia

901 Conley Rd, Columbia, MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Oct 5 to Oct 6
$72 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
7.2/10 Good! (1,015 reviews)
"We were very pleased with the property. Well maintained, clean, comfortable beds and nice shower. I love it when breakfast has hot options like waffles, biscuits and gravy and scrambled eggs, as well as the fruit, cereal ,yogurt, sweets, coffee and juices. We will stop back here next time we come ..."

Reviewed on Sep 17, 2025

Opens in a new windowRamada by Wyndham Columbia
Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr., Lake Ozark, MO
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $118 total per night from Oct 15 to Oct 16
$118 total
Oct 15 - Oct 16
Total with taxes and fees
This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...
7.2/10 Good! (1,039 reviews)
"Our stay was okay. The main lodge was lovely, the restaurants were quite good. In our room however, it was quite apparent that there were not pressure balancing valves in the shower. A number of times during my shower the water temperature would change from where I wanted it, to extremely hot or ..."

Reviewed on Sep 22, 2025

Opens in a new windowLodge Of Four Seasons Golf Resort, Marina & Spa
Laci's Country Inn

Laci's Country Inn

410 N Vaughn St, Knob Noster, MO
$66 nightly
The price is $72 total per night from Oct 3 to Oct 4
$72 total
Oct 3 - Oct 4
Total with taxes and fees
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
6.8/10 (159 reviews)
"The room was adequate sized and the tv worked well. Nice shower!"

Reviewed on Jul 6, 2025

Opens in a new windowLaci's Country Inn
Super 8 by Wyndham Columbia Clark Lane

Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln, Columbia, MO
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $64 total per night from Oct 5 to Oct 6
$64 total
Oct 5 - Oct 6
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...
6.4/10 (995 reviews)
"Perfectly adequate for the price, it’s a budget motel but it’s mostly comfortable. The mattress is terrible and lobby had an odd odor, but it was convenient and the right price for me."

Reviewed on Sep 25, 2025

Opens in a new windowSuper 8 by Wyndham Columbia Clark Lane
Don't see what you're looking for?
See all available properties in Central Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Central Missouri

Latibe Retreat Lakefront Condo for 4 w/ Balcony & Pool Access

Latibe Retreat Lakefront Condo for 4 w/ Balcony & Pool Access

40 Lighthouse Road, Lake Ozark,, Missouri 65049, United States, Lake Ozark, MO
Get rates
10/10 Exceptional! (1 review)

Central Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Central Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Central Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Central Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Central Missouri, and plan your next opulent escape.


Central Missouri hotels essential information

Accommodation
4,659 hotels
Lowest Price
$64
Highest Price
$194
Popular hotels
Ramada by Wyndham Columbia, voco, The Tiger Hotel, Columbia, MO by IHG, Lodge Of Four Seasons Golf Resort, Marina & Spa, Camden on the Lake Resort & Spa, Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel, Laci's Country Inn, Best Western Plus Columbia Inn, Super 8 by Wyndham Columbia Clark Lane

Popular Luxury Stays in Central Missouri

5 Stars Luxury stays in Central Missouri
Hotels 5 Stars
Hotels 5 Stars
Luxury stays in Central Missouri with spa
Hotels with Spa
Hotels with Spa

Recent Central Missouri Hotel Reviews By Fellow Wanderers

Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"?"
A verified traveler stayed at Baymont by Wyndham Columbia, MO
Baymont by Wyndham Columbia, MO

Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity