American Airlines Flight 4566 Deals & Information (2025/2026)

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American Airlines Flight 4566 Route Deals From $65

The cheapest prices found with in the last 7 days for return flights were $137 and $65 for one-way flights to John Glenn Columbus Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 9 - Wed, Sep 10
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$137 Roundtrip, found 3 days ago
$137
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Sep 9 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 10, priced at $137 found 3 days ago
Fri, Sep 5 - Sun, Sep 7
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$183 Roundtrip, found 1 day ago
$183
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 5 from O'Hare Intl. to John Glenn Columbus Intl., returning Sun, Sep 7, priced at $183 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $189 found 1 day ago
Fri, Sep 5 - Sun, Sep 7
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 5 from O'Hare Intl. to John Glenn Columbus Intl., returning Sun, Sep 7, priced at $193 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$197 Roundtrip, found 1 day ago
$197
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $197 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$205 Roundtrip, found 1 day ago
$205
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $205 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$213 Roundtrip, found 1 day ago
$213
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $213 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$215 Roundtrip, found 1 day ago
$215
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $215 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $223 found 1 day ago
Wed, Sep 17 - Wed, Sep 24
ORD
O'Hare Intl.
CMH
John Glenn Columbus Intl.
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from O'Hare Intl. to John Glenn Columbus Intl., returning Wed, Sep 24, priced at $228 found 1 day ago

Frequently asked questions

What route does flight number AA4566 take?
AA4566 takes multiple routes. The most frequently flown is BUF to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), which is a direct flight. This service usually takes 1 hour and 57 minutes. That said, there are likely to be other flights with this number that are multi-stop.
What kind of plane is on flight number AA4566?
If you've booked a seat on flight AA4566 from BUF to CLT, there's a good chance you'll be setting off on the Embraer 175. This flight number serves numerous routes, but this is the most popular one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4566 flight with Travelocity, please visit our Customer Service Portal.