$183 Cheap American Airlines flights from Minneapolis to Knoxville (MSP to TYS)

Q: How long is an American Airlines flight from MSP to TYS?

No horrid jet lag, no legs craving a stretch — there's a lot to be said for short-haul flights. If you're heading away with American Airlines from MSP to TYS, the journey will fly by in an average of 3 hours and 49 minutes.

Find The Best Day To Fly from Minneapolis to Knoxville

Amazing American Airlines MSP to TYS Flight Deals

The cheapest flights to McGhee Tyson found within the past 7 days were $275 round trip and $183 one way. Prices and availability subject to change. Additional terms may apply.

Tue, Sep 23 - Tue, Sep 30

MSP

Minneapolis

TYS

Knoxville

$275

Roundtrip

found 5 days ago

Mon, Oct 6 - Sat, Oct 11

MSP

Minneapolis

TYS

Knoxville

$302

Roundtrip

found 3 days ago

Thu, Sep 25 - Mon, Sep 29

MSP

Minneapolis

TYS

Knoxville

$305

Roundtrip

found 4 days ago

Thu, Aug 7 - Sat, Aug 9

MSP

Minneapolis

TYS

Knoxville

$307

Roundtrip

found 3 days ago

Thu, Sep 11 - Sun, Sep 14

MSP

Minneapolis

TYS

Knoxville

$310

Roundtrip

found 22 hours ago

Thu, Aug 14 - Sun, Aug 17

MSP

Minneapolis

TYS

Knoxville

$316

Roundtrip

found 1 hour ago

TYS From MSP Economy Coach Packages on Similar Airlines

Price found within the past 48 hours. Click for updated prices.

Country Cascades Waterpark Resort

per person

Jul 31 - Aug 4

found 12 hours ago

Roundtrip non-stop flight included

Minneapolis (MSP) to Knoxville (TYS)

Westgate Smoky Mountain Resort & Water Park

per person

Aug 4 - Aug 8

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to Knoxville (TYS)

The Oliver Hotel

per person

Aug 4 - Aug 8

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to Knoxville (TYS)

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Frequently asked questions

Can I catch a flight from Wold--Chamberlain Field to McGhee Tyson Airport (TYS) right now?

For info on any present Knoxville Airport quarantine requirements and travel advice, go to the Covid-19 Travel Advisor. Look before you book your flight, so you don't get caught out en route.

What terminal is American Airlines at Wold--Chamberlain Field?

As soon as you're issued your boarding pass for your American Airlines flight from MSP to McGhee Tyson Airport (TYS), check if the terminal details are listed on it. If not, you might like to contact your airline. They should be able to advise where you'll be flying into and out of.

Are there American Airlines non-stop flights from MSP to TYS?

Unfortunately, there aren't any direct flights between Wold--Chamberlain Field and McGhee Tyson Airport (TYS) with American Airlines. You should be prepared to make a stopover if you have to stick to this route and airline.

How long is an American Airlines flight from MSP to TYS?

No horrid jet lag, no legs craving a stretch --- there's a lot to be said for short-haul flights. If you're heading away with American Airlines from MSP to TYS, the journey will fly by in an average of 3 hours and 49 minutes.

How many direct and indirect flights does American Airlines fly from MSP to TYS?

You'll have a great deal of options if you fly with American Airlines from MSP to TYS. At the moment, it operates around 3 flights per day.

If I am not able to travel due to COVID-19, can I change my booking to a later date?

For more info about changing your flight to McGhee Tyson Airport (TYS), please visit our Customer Service Portal.

What is the best day to buy a plane ticket?

This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.

What are the cheapest days to fly?

Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.

How far in advance can you book a flight?

Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

American Airlines Airports
Airport code	Country	Airport name	Number of flights
DFW	USA	Dallas-Fort Worth Intl.	599
CLT	USA	Charlotte-Douglas Intl.	536
ORD	USA	O'Hare Intl.	317
PHL	USA	Philadelphia Intl.	247
MIA	USA	Miami Intl.	193
DCA	USA	Ronald Reagan Washington National	152
PHX	USA	Sky Harbor Intl.	141
LAX	USA	Los Angeles Intl.	81
LGA	USA	LaGuardia	72
BOS	USA	Logan Intl.	57

Travelers ❤️ these 🏨 after their flight to Knoxville

Hilton Knoxville Airport

2001 Alcoa Hwy, Alcoa, TN

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,002 reviews)

"Very clean but noisy AC otherwise good."

Reviewed on Jul 3, 2025

La Quinta Inn & Suites by Wyndham Knoxville Airport

126 Cusick Road, Alcoa, TN

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...

8.6/10 Excellent! (1,457 reviews)

"I checked beds for bed bugs and found trash under the mattress and in the floor next to the bedframe."

Reviewed on Jul 4, 2025

Courtyard Knoxville Airport Alcoa

141 Furrow Way, Alcoa, TN

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.6/10 Excellent! (694 reviews)

Handicap...no

"The room was a handicap room. The bathroom was not!!!!! The step in shower was great until I opened the door to take a shower and saw only one bar; the shower needs at least three bars!!!! The toilet was a joke...the toilet was not higher and there were NO bars. It was not funny trying to get up. ..."

Reviewed on Jul 1, 2025

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Popular American Airlines Flight Routes from MSP

Top American Airlines Flight Routes from TYS

Top Flights for American Airlines originating from MSP

Domestic

International

Most Popular

Flights

Dallas to Nashville (DFW - BNA)Los Angeles to Nashville (LAX - BNA)Nashville to New York (BNA - JFK)Phoenix to Minneapolis (PHX - MSP)Detroit to Nashville (DTW - BNA)JetBlue Airways Boston (BOS) to Nashville (BNA) flightsMinneapolis to Miami (MSP - MIA)Delta Minneapolis - St. Paul (MSP) to Phoenix (PHX) flightsPhiladelphia to Nashville (PHL - BNA)Minneapolis to Denver (MSP - DEN)Nashville to Dallas (BNA - DFW)Delta Minneapolis - St. Paul (MSP) to Honolulu (HNL) flightsTampa to Nashville (TPA - BNA)Minneapolis to Phoenix (MSP - PHX)Minneapolis to Dallas (MSP - DFW)Nashville to Los Angeles (BNA - LAX)Minneapolis to Los Angeles (MSP - LAX)Minneapolis to Orlando (MSP - MCO)JetBlue Airways New York (JFK) to Nashville (BNA) flightsNashville to Orlando (BNA - MCO)Chicago to Nashville (ORD - BNA)Memphis to Orlando (MEM - MCO)Nashville to Miami (BNA - MIA)Delta Minneapolis - St. Paul (MSP) to Las Vegas (LAS) flightsMinneapolis to Tampa (MSP - TPA)Denver to Minneapolis (DEN - MSP)Dallas to Minneapolis (DFW - MSP)Delta Minneapolis - St. Paul (MSP) to Seattle (SEA) flightsLos Angeles to Minneapolis (LAX - MSP)Orlando to Nashville (MCO - BNA)

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.